Drug & supplement interaction

Hedge-hyssop + Pseudoephedrine Sulfate

Pseudoephedrine Sulfate brand names: Drixoral N.D., Afrinol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hedge-hyssop and Pseudoephedrine Sulfate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hedge-hyssop and Pseudoephedrine Sulfate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pseudoephedrine Sulfate and Hedge-hyssop in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hedge-hyssop at all — not against Pseudoephedrine Sulfate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hedge-hyssop safety at a glance

Hedge-hyssop overall Avoid Hedge-hyssop is considered toxic and can cause severe gastrointestinal and systemic poisoning.
Pregnancy Unsafe When used orally due to toxic potential. Read the full pregnancy detail
Breastfeeding Unsafe When used orally due to toxic potential. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pseudoephedrine Sulfate and Hedge-hyssop? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hedge-hyssop Itself Has Been Linked To

This is not an interaction — nothing below involves Pseudoephedrine Sulfate. It is the side-effect record for Hedge-hyssop on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hedge-hyssop, this list is the first place to look.

  • Passing urine more often / Diarrhea / Vomiting Additional detail

    “Orally, taken in toxic doses, hedge-hyssop may cause vomiting, bloody diarrhea, colic, and kidney irritation characterized by initial diuresis followed by anuria. When people ingest very large amounts, spasms, paralysis, and circulatory collapse occur. Death occurs rarely (18).”

    Hedge-hyssop · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Hedge-hyssop — expand a row for the licensed statement it rests on. We haven’t matched Pseudoephedrine Sulfate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Pseudoephedrine Sulfate.

Special populations

Hedge-hyssop in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally due to toxic potential.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Hedge-hyssop or Pseudoephedrine Sulfate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hedge-hyssop or Pseudoephedrine Sulfate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Pseudoephedrine Sulfate

This page covers Hedge-hyssop only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pseudoephedrine Sulfate page lists 62 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 44 moderate · 13 minor.

From our pharmacist’s overview on the Pseudoephedrine Sulfate page

“Most people reach for pseudoephedrine (Afrinol, Drixoral N.D.) for a stuffy nose without much thought, often with their usual coffee, tea, or a weight-loss supplement nearby, and that casual pairing is where the trouble sits. Pseudoephedrine already pushes heart rate and blood pressure up, and 44 of the 62 supplements on file act as st…”

Reviewed by 2 · Jul 18, 2026

Open the Pseudoephedrine Sulfate interaction page

How much people look this up

Where Hedge-hyssop and Pseudoephedrine Sulfate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hedge-hyssop
Steady interest

#921 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pseudoephedrine Sulfate
Steady interest

#2,193 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hedge-hyssop reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hedge-hyssop and Pseudoephedrine Sulfate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hedge-hyssop

What is Hedge-hyssop?

  • Constipation and as a laxative
  • Fluid retention (diuretic use)
  • Liver and digestive complaints
  • Skin conditions (traditional/topical)
  • Inducing vomiting (historical purgative)

Hedge-hyssop is a traditional European herb that was historically used as a strong laxative, diuretic, and purgative, but it is considered toxic and is not recommended for self-treatment. There is no reliable modern evidence that it is safe or effective, and serious poisoning has been reported, so it is best avoided.

Gratiola officinalis · Plantaginaceae · Aerial parts (leaves and flowering stems), sometimes the root · Dried herb, tincture, and historically homeopathic preparations

An interaction check asks whether these two react with each other — it does not ask whether Hedge-hyssop is a good idea for someone in your situation. Here is what our Hedge-hyssop record says about it on its own.

Hedge-hyssop: dosing

There is no established safe or standardized dose of hedge-hyssop. Because the plant is toxic and the margin between a traditional dose and a harmful dose is narrow, no specific amount can be recommended.We do not advise self-treating with this herb.

From our Hedge-hyssop monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hedge-hyssop monograph & all interactions
Medication

About Pseudoephedrine

What Is Pseudoephedrine Used For?

Brand names: Drixoral N.D., Afrinol

Pseudoephedrine temporarily relieves nasal congestion and sinus pressure caused by the common cold, hay fever, or other upper respiratory allergies. Most products also relieve sinus congestion and pressure, and help restore easier breathing through the nose.

Children's Sudafed oral solution additionally promotes nasal and/or sinus drainage. The Nasal Decongestant tablet specifically notes that it temporarily restores freer breathing through the nose.

See full Pseudoephedrine drug information
Keep checking

Other Drugs & Hedge-hyssop

Browse every other medication we’ve checked against Hedge-hyssop — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hedge-hyssop against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hedge-hyssop list.

See the full Hedge-hyssop interactions page
See every supplement checked against Pseudoephedrine Sulfate, ranked by severity
Evidence & sources

Hedge-hyssop References

The 1 references that drive our Hedge-hyssop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hedge-hyssop and Pseudoephedrine Sulfate Together: Common Questions

Is it safe to take Hedge-hyssop with Pseudoephedrine Sulfate?
We do not list a known interaction between Hedge-hyssop and Pseudoephedrine Sulfate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Pseudoephedrine Sulfate interact with any supplements?
Yes. Pseudoephedrine Sulfate has documented interactions with 62 supplements in our database — Hedge-hyssop is not one of them. The Pseudoephedrine Sulfate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hedge-hyssop monograph Uses, safety profile, and every drug interaction in one place Pseudoephedrine drug information The full plain-English guide to this medication Pseudoephedrine Sulfate supplement interactions Every supplement checked against Pseudoephedrine Sulfate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pseudoephedrine Sulfate and Hedge-hyssop?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.