Medication interaction hub

What Supplements Interact with Amphetamine Sulfate?

Amphetamine Sulfate brand names: Benzedrine, Evekeo ODT. Every interaction below applies to the brands too.

115 Interactions 5 Major 91 Moderate 19 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amphetamine Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amphetamine Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Amphetamine sulfate (Benzedrine, Evekeo ODT) is a prescription stimulant, and most of what earns this list genuine respect is more stimulation piled on top of it. The riskiest entries, ephedra chief among them, add to its effects on heart rate and blood pressure, and even everyday caffeine, whether from coffee, tea, or cola nut, pushes in the same direction at a milder level. This is a page to read carefully before mixing anything with the medication.

Two other patterns run through the rest. A large group of herbs shares the liver pathway (CYP2D6) that helps clear amphetamine, so some can slow its breakdown and nudge its level upward. A smaller set interferes with the absorption of anything swallowed, activated charcoal most seriously, so keep those well apart from your dose. Of the 115 ingredients on file, 91 rate moderate and 19 minor, and four of the five majors are stimulant combinations.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 91 Minor 19 No known interaction 1,337

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amphetamine Sulfate: Top Interactions at a Glance

The Amphetamine Sulfate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 115 interacting ingredients — plus 1,337 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amphetamine Sulfate Combinations Today

The Amphetamine Sulfate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Eleuthero + Amphetamine Sulfatei

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Gamma Butyrolactone (gbl) + Amphetamine Sulfatei

Theoretically, amphetamines may increase or decrease the therapeutic and adverse effects of GBL.

Read the full interaction Major Likelihood Probable Peyote + Amphetamine Sulfatei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Minor Likelihood Possible Tyramine + Amphetamine Sulfatei

Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.

Read the full interaction Moderate Likelihood Possible Active Hexose Correlated Compound (ahcc) + Amphetamine Sulfatei

Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Amphetamine Sulfatei

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Amphetamine Sulfate

All 1,452 ingredients in our database, ranked by severity — 115 with a Amphetamine Sulfate interaction on file and 1,337 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amphetamine Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Eleuthero with Amphetamine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Amphetamine Sulfate answer

Can you take Gamma Butyrolactone (gbl) with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, amphetamines may increase or decrease the therapeutic and adverse effects of GBL.

Full Gamma Butyrolactone (gbl) + Amphetamine Sulfate answer

Can you take Peyote with Amphetamine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Amphetamine Sulfate answer

Can you take Tyramine with Amphetamine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Tyramine + Amphetamine Sulfate answer

Can you take Active Hexose Correlated Compound (ahcc) with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Amphetamine Sulfate answer

Can you take Activated Charcoal with Amphetamine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Amphetamine Sulfate answer

Can you take Ephedra with Amphetamine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Ephedra + Amphetamine Sulfate answer

Can you take Rauvolfia Vomitoria with Amphetamine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Amphetamine Sulfate answer

Can you take Sida Cordifolia with Amphetamine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Amphetamine Sulfate answer

Can you take Ayahuasca with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.

Full Ayahuasca + Amphetamine Sulfate answer

Can you take Black Tea with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Amphetamine Sulfate answer

Can you take Caffeine with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Amphetamine Sulfate answer

Can you take Cocoa with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Amphetamine Sulfate answer

Can you take Coffee with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Amphetamine Sulfate answer

Can you take Coffee Charcoal with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Amphetamine Sulfate answer

Can you take Cola Nut with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Amphetamine Sulfate answer

Can you take European Mandrake with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Amphetamine Sulfate answer

Can you take Fever Bark with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Amphetamine Sulfate answer

Can you take Glucomannan with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Amphetamine Sulfate answer

Can you take Goldenseal with Amphetamine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Amphetamine Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amphetamine Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amphetamine Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amphetamine Sulfate sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Amphetamine Sulfate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Amphetamine Sulfate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amphetamine Sulfate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amphetamine Sulfate through this category.

Amphetamines 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Amphetamine Sulfate through this category.

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Take a Supplement Product? Check the Whole Bottle Against Amphetamine Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amphetamine Sulfate.

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Pharmacist Counseling Corner

Amphetamine Sulfate & Supplements: Common Questions

What supplements interact with Amphetamine Sulfate?
Our database currently documents 115 ingredients with a known Amphetamine Sulfate interaction (5 major, 91 moderate, 19 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 115. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Amphetamine Sulfate supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amphetamine Sulfate?
Plenty of supplements coexist fine with Amphetamine Sulfate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Benzedrine have the same supplement interactions as Amphetamine Sulfate?
Yes — Benzedrine, Evekeo ODT all contain Amphetamine Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Amphetamine Sulfate and my other medications?
This page covers Amphetamine Sulfate against supplements and herbal ingredients. Checking Amphetamine Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.