Medication interaction hub

What Supplements Interact with Lisdexamfetamine?

Lisdexamfetamine brand name: Vyvanse. Every interaction below applies to the brands too.

126 Interactions 6 Major 98 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lisdexamfetamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lisdexamfetamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

126 supplements and herbal ingredients have interactions with Lisdexamfetamine on file in the HelloPharmacist interaction database — 6 rated major, 98 moderate, and 22 minor. The most serious involve Activated Charcoal, Ephedra, Lithium, Peyote and Rauvolfia Vomitoria.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Lisdexamfetamine.

Major 6 Moderate 98 Minor 22 No known interaction 1,326

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lisdexamfetamine: Top Interactions at a Glance

The Lisdexamfetamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 126 interacting ingredients — plus 1,326 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lisdexamfetamine Combinations Today

The Lisdexamfetamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Caffeine + Lisdexamfetaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Berberine + Lisdexamfetaminei

Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.

Read the full interaction Minor Likelihood Possible Ashwagandha + Lisdexamfetaminei

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Read the full interaction Moderate Likelihood Possible Kratom + Lisdexamfetaminei

Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndrome.

Read the full interaction Moderate Likelihood Possible Cannabidiol (cbd) + Lisdexamfetaminei

Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Probable Coffee + Lisdexamfetaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Lisdexamfetamine

All 1,452 ingredients in our database, ranked by severity — 126 with a Lisdexamfetamine interaction on file and 1,326 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lisdexamfetamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Caffeine with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Lisdexamfetamine answer

Can you take Berberine with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.

Full Berberine + Lisdexamfetamine answer

Can you take Ashwagandha with Lisdexamfetamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.

Full Ashwagandha + Lisdexamfetamine answer

Can you take Kratom with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndr...

Full Kratom + Lisdexamfetamine answer

Can you take Cannabidiol (cbd) with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Full Cannabidiol (cbd) + Lisdexamfetamine answer

Can you take Kava with Lisdexamfetamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Lisdexamfetamine answer

Can you take Theanine with Lisdexamfetamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.

Full Theanine + Lisdexamfetamine answer

Can you take Valerian with Lisdexamfetamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Full Valerian + Lisdexamfetamine answer

Can you take Activated Charcoal with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Lisdexamfetamine answer

Can you take Ephedra with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Ephedra + Lisdexamfetamine answer

Can you take Lithium with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Full Lithium + Lisdexamfetamine answer

Can you take Peyote with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Lisdexamfetamine answer

Can you take Rauvolfia Vomitoria with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Lisdexamfetamine answer

Can you take Sida Cordifolia with Lisdexamfetamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Lisdexamfetamine answer

Can you take Ayahuasca with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.

Full Ayahuasca + Lisdexamfetamine answer

Can you take Black Tea with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Lisdexamfetamine answer

Can you take Cocoa with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Lisdexamfetamine answer

Can you take Coffee with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Lisdexamfetamine answer

Can you take Coffee Charcoal with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Lisdexamfetamine answer

Can you take Cola Nut with Lisdexamfetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Lisdexamfetamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lisdexamfetamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lisdexamfetamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lisdexamfetamine sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Lisdexamfetamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Lisdexamfetamine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Lisdexamfetamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lisdexamfetamine through this category.

Amphetamines 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Lisdexamfetamine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Lisdexamfetamine through this category.

About Lisdexamfetamine

Lisdexamfetamine is a central nervous system stimulant used to treat ADHD and binge eating disorder by changing brain chemicals.

Generic name: Lisdexamfetamine  ·  Brand name: Vyvanse.

See the full Lisdexamfetamine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lisdexamfetamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lisdexamfetamine.

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Pharmacist Counseling Corner

Lisdexamfetamine & Supplements: Common Questions

What supplements interact with Lisdexamfetamine?
Our database currently documents 126 ingredients with a known Lisdexamfetamine interaction (6 major, 98 moderate, 22 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 126. The highest-ranked right now: Activated Charcoal, Ephedra, Lithium.
Which Lisdexamfetamine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Lithium, Peyote and Rauvolfia Vomitoria, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lisdexamfetamine?
Plenty of supplements coexist fine with Lisdexamfetamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Vyvanse have the same supplement interactions as Lisdexamfetamine?
Yes — Vyvanse all contain Lisdexamfetamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lisdexamfetamine and my other medications?
This page covers Lisdexamfetamine against supplements and herbal ingredients. Checking Lisdexamfetamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lisdexamfetamine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.