Medication interaction hub

What Supplements Interact with Methamphetamine?

Methamphetamine brand name: Desoxyn. Every interaction below applies to the brands too.

126 Interactions 6 Major 99 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Methamphetamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Methamphetamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prescription methamphetamine (Desoxyn) is a potent stimulant, usually given for ADHD, and this is a list I would want anyone taking it to read closely. Six of the 126 supplement and herbal ingredients on file carry a major rating, and those six deserve your attention first. Ephedra, Sida cordifolia, and similar stimulant botanicals pile their effects on top of the drug's own, pushing heart rate and blood pressure higher than the prescriber intended. Activated charcoal works the opposite way, soaking up the dose so less of it reaches you.

Most of the 99 moderate entries repeat a few themes. Everyday caffeine sources, coffee, tea, cocoa, add to the total stimulant load. Twenty serotonergic ingredients raise the odds of serotonin syndrome, a dangerous excess of serotonin. Sixty more can slow how the body clears methamphetamine, nudging its level upward, while the last 21 rate only minor.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 99 Minor 21 No known interaction 1,326

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Methamphetamine: Top Interactions at a Glance

The Methamphetamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 126 interacting ingredients — plus 1,326 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Methamphetamine Combinations Today

The Methamphetamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Black Psyllium + Methamphetaminei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Gamma-hydroxybutyrate (ghb) + Methamphetaminei

Concomitant use of amphetamines and GHB can increase the risk of severe adverse effects.

Read the full interaction Moderate Likelihood Possible St. John's Wort + Methamphetaminei

Theoretically, St.

Read the full interaction Moderate Likelihood Possible 5-htp + Methamphetaminei

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Read the full interaction Moderate Likelihood Possible 1,3-dmaa + Methamphetaminei

1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Read the full interaction Moderate Likelihood Possible Panax Ginseng + Methamphetaminei

Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.

Read the full interaction
The complete list

Every Supplement Checked Against Methamphetamine

All 1,452 ingredients in our database, ranked by severity — 126 with a Methamphetamine interaction on file and 1,326 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Methamphetamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Psyllium with Methamphetamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Methamphetamine answer

Can you take Gamma-hydroxybutyrate (ghb) with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of amphetamines and GHB can increase the risk of severe adverse effects.

Full Gamma-hydroxybutyrate (ghb) + Methamphetamine answer

Can you take St. John's Wort with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Methamphetamine answer

Can you take 5-htp with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + Methamphetamine answer

Can you take 1,3-dmaa with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Methamphetamine answer

Can you take Calamus with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Methamphetamine answer

Can you take Cannabidiol (cbd) with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Full Cannabidiol (cbd) + Methamphetamine answer

Can you take Ceylon Leadwort with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.

Full Ceylon Leadwort + Methamphetamine answer

Can you take Cinchona with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.

Full Cinchona + Methamphetamine answer

Can you take Clove with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.

Full Clove + Methamphetamine answer

Can you take Corydalis Yanhusuo with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.

Full Corydalis Yanhusuo + Methamphetamine answer

Can you take Dimethylhexylamine (dmha) with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Methamphetamine answer

Can you take English Ivy with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Full English Ivy + Methamphetamine answer

Can you take Ergot with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.

Full Ergot + Methamphetamine answer

Can you take Eucalyptus with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.

Full Eucalyptus + Methamphetamine answer

Can you take False Unicorn with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.

Full False Unicorn + Methamphetamine answer

Can you take Fermented Wheat Germ Extract with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse e...

Full Fermented Wheat Germ Extract + Methamphetamine answer

Can you take Feverfew with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.

Full Feverfew + Methamphetamine answer

Can you take Fo-ti with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Fo-ti + Methamphetamine answer

Can you take Gamma Butyrolactone (gbl) with Methamphetamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, amphetamines may increase or decrease the therapeutic and adverse effects of GBL.

Full Gamma Butyrolactone (gbl) + Methamphetamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Methamphetamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Methamphetamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Methamphetamine sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Methamphetamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Methamphetamine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Methamphetamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Methamphetamine through this category.

Amphetamines 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Methamphetamine through this category.

Methamphetamine (Desoxyn) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Methamphetamine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Methamphetamine through this category.

About Methamphetamine

A central nervous system stimulant used to treat ADHD symptoms and, short-term, to help with weight loss in obese people.

Generic name: Methamphetamine  ·  Brand name: Desoxyn.

See the full Methamphetamine drug information
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Pharmacist Counseling Corner

Methamphetamine & Supplements: Common Questions

What supplements interact with Methamphetamine?
In our interaction database, 126 supplement and herbal ingredients have an interaction with Methamphetamine on file — 6 rated major, 99 moderate, and 21 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Ephedra, Lithium.
Which Methamphetamine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Lithium, Peyote and Rauvolfia Vomitoria, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Methamphetamine?
That depends entirely on which supplement. The honest answer for Methamphetamine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Desoxyn have the same supplement interactions as Methamphetamine?
Yes — Desoxyn all contain Methamphetamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Methamphetamine and my other medications?
This page covers Methamphetamine against supplements and herbal ingredients. Checking Methamphetamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Methamphetamine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.