Medication interaction hub

What Supplements Interact with Dextroamphetamine (patch)?

Dextroamphetamine (patch) brand name: Xelstrym. Every interaction below applies to the brands too.

112 Interactions 5 Major 93 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dextroamphetamine (patch)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dextroamphetamine (patch) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ephedra sits at the very top of the concerns for anyone using the dextroamphetamine patch (Xelstrym). The herb is a stimulant in its own right, and stacking two stimulants can push blood pressure and heart strain into dangerous territory. That pattern shapes most of this list, which earns real caution: 44 of the 112 flagged ingredients add stimulant load, caffeine in all its everyday forms included, and 20 more raise serotonin concerns, with lithium the most serious of those.

All five major-rated entries fall in those two camps, while the 93 moderate and 14 minor ones mostly repeat the same effects at gentler volume. Less obvious are the 60 ingredients that can slow the CYP2D6 enzyme that helps clear this drug, potentially letting amphetamine levels climb unnoticed. Know the five majors first, and count every cup of coffee or tea as part of the stimulant dose you are already wearing.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 93 Minor 14 No known interaction 1,340

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Dextroamphetamine (patch): Top Interactions at a Glance

The Dextroamphetamine (patch) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 112 interacting ingredients — plus 1,340 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Dextroamphetamine (patch) Combinations Today

The Dextroamphetamine (patch) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible L-tryptophan + Dextroamphetamine (patch)i

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Read the full interaction Moderate Likelihood Possible Cannabidiol (cbd) + Dextroamphetamine (patch)i

Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Probable Black Tea + Dextroamphetamine (patch)i

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Probable Caffeine + Dextroamphetamine (patch)i

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Major Likelihood Probable Ephedra + Dextroamphetamine (patch)i

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Lithium + Dextroamphetamine (patch)i

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction
The complete list

Every Supplement Checked Against Dextroamphetamine (patch)

All 1,452 ingredients in our database, ranked by severity — 112 with a Dextroamphetamine (patch) interaction on file and 1,340 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dextroamphetamine (patch)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take L-tryptophan with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + Dextroamphetamine (patch) answer

Can you take Cannabidiol (cbd) with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Full Cannabidiol (cbd) + Dextroamphetamine (patch) answer

Can you take Black Tea with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Dextroamphetamine (patch) answer

Can you take Caffeine with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Dextroamphetamine (patch) answer

Can you take Green Tea with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Dextroamphetamine (patch) answer

Can you take Ilex Guayusa with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Dextroamphetamine (patch) answer

Can you take Oolong Tea with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Oolong Tea + Dextroamphetamine (patch) answer

Can you take Psilocybin with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Dextroamphetamine (patch) answer

Can you take Pu-erh Tea with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Pu-erh Tea + Dextroamphetamine (patch) answer

Can you take Syrian Rue with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Syrian Rue + Dextroamphetamine (patch) answer

Can you take Yerba Mate with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Dextroamphetamine (patch) answer

Can you take 1,3-dmaa with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Dextroamphetamine (patch) answer

Can you take 1,3-dmba with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.

Full 1,3-dmba + Dextroamphetamine (patch) answer

Can you take 1,4-butanediol with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, amphetamines may increase or decrease the therapeutic and adverse effects of 1,4-butanediol.

Full 1,4-butanediol + Dextroamphetamine (patch) answer

Can you take 1,4-dmaa with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Dextroamphetamine (patch) answer

Can you take 5-htp with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + Dextroamphetamine (patch) answer

Can you take Acacia Rigidula with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 su...

Full Acacia Rigidula + Dextroamphetamine (patch) answer

Can you take Acetyl-l-carnitine with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Dextroamphetamine (patch) answer

Can you take Aconite with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovasc...

Full Aconite + Dextroamphetamine (patch) answer

Can you take Active Hexose Correlated Compound (ahcc) with Dextroamphetamine (patch)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Dextroamphetamine (patch) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dextroamphetamine (patch) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dextroamphetamine (patch), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dextroamphetamine (patch) sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Dextroamphetamine (patch) through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Dextroamphetamine (patch) through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Dextroamphetamine (patch) through this category.

Amphetamines 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Dextroamphetamine (patch) through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dextroamphetamine (patch) through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Dextroamphetamine (patch) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dextroamphetamine (patch)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dextroamphetamine (patch).

Search a supplement product

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Pharmacist Counseling Corner

Dextroamphetamine (patch) & Supplements: Common Questions

What supplements interact with Dextroamphetamine (patch)?
Our database currently documents 112 ingredients with a known Dextroamphetamine (patch) interaction (5 major, 93 moderate, 14 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 112. The highest-ranked right now: Ephedra, Lithium, Peyote.
Which Dextroamphetamine (patch) supplement interactions are the most serious?
The 5 major-rated combinations — led by Ephedra, Lithium, Peyote, Rauvolfia Vomitoria and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dextroamphetamine (patch)?
Plenty of supplements coexist fine with Dextroamphetamine (patch); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Xelstrym have the same supplement interactions as Dextroamphetamine (patch)?
Yes — Xelstrym all contain Dextroamphetamine (patch), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dextroamphetamine (patch) and my other medications?
This page covers Dextroamphetamine (patch) against supplements and herbal ingredients. Checking Dextroamphetamine (patch) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.