Methamphetamine

28 interactions 5 explained in plain English
Also sold as: Desoxyn
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Acetaminophen And Codeine Dolasetron Nalbuphine Injection Dexlansoprazole Dacomitinib
1 Contraindicated 26 Major 1 Moderate
All (28) Contraindicated (1) Major (26) Moderate (1)

Contraindicated

Methamphetamine Linezolid Injection Zyvox An increased risk of serotonergic syndrome and an increased risk of hypertensive crisis Details

Major

Methamphetamine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Methamphetamine Omeprazole Gastrobim Explained Increased exposure to amphetamine Details Methamphetamine Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Methamphetamine Sertraline Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Methamphetamine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Methamphetamine Acetazolamide Diamox® Sequels® Increased exposure to amphetamine Details Methamphetamine Abiraterone Abirtega Increased amphetamine exposure and increased risk of serotonin syndrome Details Methamphetamine Butorphanol Injection Butorphic An increased risk of serotonin syndrome Details Methamphetamine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome Details Methamphetamine Dacomitinib Vizimpro Increased amphetamine exposure and increased risk of serotonin syndrome Details Methamphetamine Dexlansoprazole Dexilant Increased exposure to amphetamine Details Methamphetamine Dolasetron Anzemet An increased risk of serotonin syndrome Details Methamphetamine Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Methamphetamine Esomeprazole Nexium Increased exposure to amphetamine Details Methamphetamine Esomeprazole Injection Nexium Increased exposure to amphetamine Details Methamphetamine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Methamphetamine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Methamphetamine Granisetron Injection Granisol An increased risk of serotonin syndrome Details Methamphetamine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Methamphetamine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Methamphetamine Lansoprazole Prevacid Increased exposure to amphetamine Details Methamphetamine Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Methamphetamine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Methamphetamine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome Details Methamphetamine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Methamphetamine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Methamphetamine Ascorbic Acid (Vitamin C) C-500® Chewable Tablet Decreased blood levels and effectiveness of amphetamines Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.