Medication interaction hub

What Supplements Interact with Icosapent Ethyl (prescription drug)?

Icosapent Ethyl (prescription drug) brand name: Vascepa. Every interaction below applies to the brands too.

218 Interactions 3 Major 190 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Icosapent Ethyl (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Icosapent Ethyl (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Icosapent ethyl (Vascepa) is a purified fish oil medication prescribed to lower triglycerides and cut heart attack risk, and it can thin the blood a little on its own. That is exactly why this list deserves real attention before you add a supplement. Of the 218 ingredients on file, 202 also slow clotting in some way, so stacking them on Vascepa raises the odds of bruising and bleeding. Two of the three major-rated entries, danshen and piracetam, fall in that group.

The third major, activated charcoal, works differently. It can soak up medicine in your gut before it has a chance to work, and it heads a group of 17 ingredients that change how oral drugs absorb, so keep those well separated from your capsule. The remaining entries, 190 rated moderate and 25 minor, mostly carry smaller versions of the same bleeding concern, worth a careful scan rather than a panic.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 190 Minor 25 No known interaction 1,234

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Icosapent Ethyl (prescription drug): Top Interactions at a Glance

The most significant Icosapent Ethyl (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 218 interacting ingredients — plus 1,234 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Icosapent Ethyl (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Icosapent Ethyl (prescription drug)i

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Danshen + Icosapent Ethyl (prescription drug)i

Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Probable Piracetam + Icosapent Ethyl (prescription drug)i

Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Read the full interaction
The complete list

Every Supplement Checked Against Icosapent Ethyl (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 218 with a Icosapent Ethyl (prescription drug) interaction on file and 1,234 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Icosapent Ethyl (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cola Nut with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cola Nut + Icosapent Ethyl (prescription drug) answer

Can you take Corydalis Yanhusuo with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Corydalis Yanhusuo + Icosapent Ethyl (prescription drug) answer

Can you take Caffeine with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Caffeine + Icosapent Ethyl (prescription drug) answer

Can you take Canadian Fleabane with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Full Canadian Fleabane + Icosapent Ethyl (prescription drug) answer

Can you take Cannabis with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Cannabis + Icosapent Ethyl (prescription drug) answer

Can you take Capsicum with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Icosapent Ethyl (prescription drug) answer

Can you take Carrageenan with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Full Carrageenan + Icosapent Ethyl (prescription drug) answer

Can you take Cat's Claw with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cat's Claw + Icosapent Ethyl (prescription drug) answer

Can you take Celery with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Celery + Icosapent Ethyl (prescription drug) answer

Can you take Ceylon Leadwort with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the ri...

Full Ceylon Leadwort + Icosapent Ethyl (prescription drug) answer

Can you take Chaga with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Chaga + Icosapent Ethyl (prescription drug) answer

Can you take Chanca Piedra with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Chanca Piedra + Icosapent Ethyl (prescription drug) answer

Can you take Chokeberry with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Chokeberry + Icosapent Ethyl (prescription drug) answer

Can you take Chrysin with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Chrysin + Icosapent Ethyl (prescription drug) answer

Can you take Cilantro with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that extracts of cilantro can inhibit platelet aggregation.

Full Cilantro + Icosapent Ethyl (prescription drug) answer

Can you take Cinchona with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might increase the drug effects and risk of bleeding with anticoagulant and antiplatelet drugs.

Full Cinchona + Icosapent Ethyl (prescription drug) answer

Can you take Cnidium with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research shows that osthol, a constituent of cnidium, inhibits blood clotting and the activity of platelets.

Full Cnidium + Icosapent Ethyl (prescription drug) answer

Can you take Cocoa with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cocoa + Icosapent Ethyl (prescription drug) answer

Can you take Cod Liver Oil with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cod liver oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cod Liver Oil + Icosapent Ethyl (prescription drug) answer

Can you take Codonopsis with Icosapent Ethyl (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, codonopsis liquor might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Codonopsis + Icosapent Ethyl (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Icosapent Ethyl (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Icosapent Ethyl (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Icosapent Ethyl (prescription drug) sits in 2 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Icosapent Ethyl (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Icosapent Ethyl (prescription drug) through this category.

About Icosapent Ethyl (prescription drug)

Icosapent ethyl is a prescription omega-3 (EPA) medicine used to lower very high triglycerides and, for Vascepa specifically, to reduce the risk of heart attack, stroke and related heart problems in certain high-risk adults on a statin.

Generic name: Icosapent Ethyl (prescription drug)  ·  Brand name: Vascepa.

See the full Icosapent Ethyl drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Icosapent Ethyl (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Icosapent Ethyl (prescription drug).

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Pharmacist Counseling Corner

Icosapent Ethyl (prescription drug) & Supplements: Common Questions

What supplements interact with Icosapent Ethyl (prescription drug)?
In our interaction database, 218 supplement and herbal ingredients have an interaction with Icosapent Ethyl (prescription drug) on file — 3 rated major, 190 moderate, and 25 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Danshen, Piracetam.
Which Icosapent Ethyl (prescription drug) supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Icosapent Ethyl (prescription drug)?
That depends entirely on which supplement. The honest answer for Icosapent Ethyl (prescription drug) is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vascepa have the same supplement interactions as Icosapent Ethyl (prescription drug)?
Yes — Vascepa all contain Icosapent Ethyl (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Icosapent Ethyl (prescription drug) and my other medications?
This page covers Icosapent Ethyl (prescription drug) against supplements and herbal ingredients. Checking Icosapent Ethyl (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Icosapent Ethyl drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.