Medication interaction hub

What Supplements Interact with Tenofovir Alafenamide Fumarate?

Tenofovir Alafenamide Fumarate brand name: Vemlidy. Every interaction below applies to the brands too.

94 Interactions 6 Major 71 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tenofovir Alafenamide Fumarate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tenofovir Alafenamide Fumarate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort is the supplement to rule out first with tenofovir alafenamide (Vemlidy). It revs up the pump that carries the drug across cell membranes, which can drain the antiviral's blood levels and give hepatitis B room to rebound. Six of the 94 interactions on file rate major, so treat this list with genuine care. The largest groups are 38 ingredients that can strain the liver, the very organ Vemlidy is defending (heavy alcohol is the standout), and 37 that can shift drug levels through that same pump.

A smaller set of six can add to the kidney strain tenofovir itself can cause, and 17 more, activated charcoal chief among them, can block absorption of medicines taken by mouth; keep those well apart from your dose. The other entries, 71 rated moderate and 17 minor, mostly replay the same liver and drug-level concerns at lower volume.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 71 Minor 17 No known interaction 1,358

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Tenofovir Alafenamide Fumarate: Top Interactions at a Glance

The most significant Tenofovir Alafenamide Fumarate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 94 interacting ingredients — plus 1,358 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Tenofovir Alafenamide Fumarate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Tenofovir Alafenamide Fumaratei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Tenofovir Alafenamide Fumaratei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Tenofovir Alafenamide Fumaratei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable St. John's Wort + Tenofovir Alafenamide Fumaratei

St.

Read the full interaction Major Likelihood Probable Wine + Tenofovir Alafenamide Fumaratei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Possible Asarabacca + Tenofovir Alafenamide Fumaratei

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Tenofovir Alafenamide Fumarate

All 1,452 ingredients in our database, ranked by severity — 94 with a Tenofovir Alafenamide Fumarate interaction on file and 1,358 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tenofovir Alafenamide Fumarate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Green Tea with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.

Full Green Tea + Tenofovir Alafenamide Fumarate answer

Can you take Red Yeast Rice with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Tenofovir Alafenamide Fumarate answer

Can you take Schisandra with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Tenofovir Alafenamide Fumarate answer

Can you take Spearmint with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Tenofovir Alafenamide Fumarate answer

Can you take Strawberry with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Tenofovir Alafenamide Fumarate answer

Can you take Sweet Annie with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Tenofovir Alafenamide Fumarate answer

Can you take Sweet Clover with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Tenofovir Alafenamide Fumarate answer

Can you take Sweet Orange with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Tenofovir Alafenamide Fumarate answer

Can you take Syrian Rue with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Tenofovir Alafenamide Fumarate answer

Can you take Testolone with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Tenofovir Alafenamide Fumarate answer

Can you take Tragacanth with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Tenofovir Alafenamide Fumarate answer

Can you take Turmeric with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Tenofovir Alafenamide Fumarate answer

Can you take Vitamin A with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Tenofovir Alafenamide Fumarate answer

Can you take White Pepper with Tenofovir Alafenamide Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of p-glycoprotein substrates.

Full White Pepper + Tenofovir Alafenamide Fumarate answer

Can you take Thyroid Extract with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Tenofovir Alafenamide Fumarate answer

Can you take Agar with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Tenofovir Alafenamide Fumarate answer

Can you take Algin with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Tenofovir Alafenamide Fumarate answer

Can you take Baikal Skullcap with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.

Full Baikal Skullcap + Tenofovir Alafenamide Fumarate answer

Can you take Black Psyllium with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Tenofovir Alafenamide Fumarate answer

Can you take Blond Psyllium with Tenofovir Alafenamide Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Tenofovir Alafenamide Fumarate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tenofovir Alafenamide Fumarate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tenofovir Alafenamide Fumarate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tenofovir Alafenamide Fumarate sits in 5 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Tenofovir Alafenamide Fumarate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Tenofovir Alafenamide Fumarate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tenofovir Alafenamide Fumarate through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Tenofovir Alafenamide Fumarate through this category.

Nucleoside Reverse Transcriptase Inhibitors (Nrtis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Tenofovir Alafenamide Fumarate through this category.

About Tenofovir Alafenamide Fumarate

Tenofovir Alafenamide Fumarate is a prescription medication also sold under the brand name Vemlidy. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Tenofovir Alafenamide Fumarate  ·  Brand name: Vemlidy.

See the full Tenofovir disoproxil fumarate/Tenofovir alafenamide drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tenofovir Alafenamide Fumarate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tenofovir Alafenamide Fumarate.

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Pharmacist Counseling Corner

Tenofovir Alafenamide Fumarate & Supplements: Common Questions

What supplements interact with Tenofovir Alafenamide Fumarate?
Our database currently documents 94 ingredients with a known Tenofovir Alafenamide Fumarate interaction (6 major, 71 moderate, 17 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 94. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Tenofovir Alafenamide Fumarate supplement interactions are the most serious?
The 6 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, St. John's Wort and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tenofovir Alafenamide Fumarate?
Plenty of supplements coexist fine with Tenofovir Alafenamide Fumarate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Vemlidy have the same supplement interactions as Tenofovir Alafenamide Fumarate?
Yes — Vemlidy all contain Tenofovir Alafenamide Fumarate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tenofovir Alafenamide Fumarate and my other medications?
This page covers Tenofovir Alafenamide Fumarate against supplements and herbal ingredients. Checking Tenofovir Alafenamide Fumarate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tenofovir disoproxil fumarate/Tenofovir alafenamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.