5-HTP 50 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking 5-HTP 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
5-HTP 50 mg is a dietary supplement by MRM Nutrition with 1 active ingredient. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-5-Hydroxytryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 5-HTP 50 mg by MRM Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP 50 mg by MRM Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 5-HTP 50 mg by MRM Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-5-Hydroxytryptophan (5-HTP), a compound your body naturally makes and uses to produce serotonin, a chemical messenger in the brain involved in mood, sleep, and appetite. The capsule also contains rice flour and cellulose as inactive filler ingredients.
Does it work?
Moderate evidence
The evidence for 5-HTP in depression is modest—it's rated possibly effective based on available data. For other conditions like Alzheimer disease and panic disorder, we don't have enough reliable evidence to say whether it works.
Down syndrome is rated possibly ineffective. If you're considering this for depression or any other condition, talk with your doctor about whether the current evidence supports a trial and how it might fit into your overall treatment plan.
How safe is it?
Well-documented data
Short-term, 5-HTP is generally well tolerated, though side effects do happen. The most common are nausea, vomiting, abdominal pain, diarrhea, dizziness, drowsiness, headache, and insomnia—often dose-related and sometimes improving with continued use.
Rare serious effects include hallucinations, mania, and aggression. Because 5-HTP affects serotonin, use it only under professional guidance.
The safety data advises against using 5-HTP during pregnancy and while breastfeeding due to insufficient safety information. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering this product.
Meds to double-check
Moderate interaction found
Before you take this, double-check with your pharmacist if you're on serotonergic medications—antidepressants (SSRIs, SNRIs, tricyclics, MAOIs), tramadol, or ondansetron, among others—because the risk of serotonin syndrome is Moderate. Also check if you take sedating drugs (sleep aids, antihistamines, some blood pressure or muscle relaxant medications) or carbidopa for Parkinson's, both Moderate concerns.
The interaction checker on this page can help you verify your specific medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
5-HTP may help some people with depression, but it's not a first-line option and comes with real side effects and medication interactions. If you're on any antidepressant, sedating medication, or carbidopa, check with your pharmacist before starting.
This is one to discuss with your doctor in the context of your full health picture.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 5-HTP 50 mg, straight from the product label.
| Brand | MRM Nutrition |
|---|---|
| Barcode (UPC) | 60949255005 |
| Net contents | 30 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 319053 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 5-HTP 50 mg by MRM Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-5-Hydroxytryptophan | 50 mg | -- |
Other ingredients: Rice Flour, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested usage: Take 1 capsule per day or as directed by your qualified healthcare provider.
Formulation
Promotes positive mood & sleep patterns May help control appetite
GF (Gluten free) Non GMO
Vegan
Mood support
Contains no added milk, egg, peanut, tree nut, fish, shellfish, soy, wheat, gluten or yeast ingredients.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Made from recycled materials
FDA Statement of Identity
Dietary Supplement
Precautions
Warning: if you are pregnant or breastfeeding, taking prescription medication such as an antidepressant, or if you have heart disease, consult your physician before using this product.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
5-HTP 50 mg by MRM Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 5-HTP 50 mg by MRM Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
L-5-Hydroxytryptophan
Interacts with398 drugs
5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...
L-5-Hydroxytryptophan monograph & interactionsOther (inactive) ingredients: Rice Flour, Cellulose. These complete the product’s ingredient list but are not active constituents.
5-HTP 50 mg by MRM Nutrition Drug Interactions
HelloPharmacist Interaction Report
MRM Nutrition's 5-HTP can interact with several classes of medications.
The most serious documented concern is with serotonergic drugs—antidepressants, certain pain relievers, and other medications that raise serotonin—because combining them with 5-HTP may increase the risk of serotonin syndrome, a potentially dangerous buildup of serotonin in your system. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you take sedating medications (sleep aids, antihistamines, some blood pressure drugs, or muscle relaxants), because 5-HTP can add to their drowsy effects. And if you're on carbidopa (Lodosyn), used for Parkinson's disease, the combination raises the risk of restlessness, anxiety, insomnia, and in rare cases, more serious serotonergic effects.
Both are Moderate-severity interactions.
Altogether, these interactions span 398 individual medications. Use the checker below to search your exact prescriptions before you start—this is one where a quick conversation with your pharmacist can save you a real headache.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against 5-HTP 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 5-HTP 50 mg interact with 398 drugs. Click any drug to see the details.
1 of the 1 ingredient in 5-HTP 50 mg interact with drugs. Each result below shows which ingredient is responsible. L-5-Hydroxytryptophan
AcepromazineAtravet
How Acepromazine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 5-HTP 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-5-Hydroxytryptophan
Carbidopa (Lodosyn)
Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.
Cns Depressants
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.
Serotonergic Drugs
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.
Brand information
Manufacturer and brand details for 5-HTP 50 mg, from the product label.
MRM Nutrition
See all MRM Nutrition products- Name
- MRM
- Street Address
- 2665 Vista Pacific Dr
- City
- Oceanside
- State
- CA
- ZipCode
- 92056
- Phone Number
- 1-800-948-6296
- Web Address
- www.mrmnutrition.com
5-HTP 50 mg by MRM Nutrition: Common Questions
Does 5-HTP 50 mg by MRM Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does 5-HTP actually do?
What are the most common side effects?
Can I take this while pregnant or breastfeeding?
Why does the product say 'use with professional guidance'?
Can I just double my dose if one capsule isn't working?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if 5-HTP 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 5-HTP 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
5-HTP 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
5-htp 32 references
- Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
- Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
- Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
- U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
- Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
- Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
- Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
- U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
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