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Dietary supplement

9-Zymes Ingredients & Drug Interactions

by Cutler Nutrition

9-Zymes label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 9-Zymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

9-Zymes is a dietary supplement by Cutler Nutrition with 4 active ingredients.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 9-Zymes by Cutler Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with 9-Zymes by Cutler Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 9-Zymes by Cutler Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.
  • “Breakdown of Proteins” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Breakdown Fats” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

9-Zymes contains 9 active ingredients—a blend of digestive enzymes designed to help break down different food components. Bromelain (from pineapple) breaks down proteins; lactase handles milk sugars; lipase breaks down fats; cellulase, hemicellulase, and a vegetal pancreatin analog work on fiber and plant material; acid-stable protease breaks down proteins in acidic stomach conditions; and alpha-amylase and amyloglucosidase help break down starches and complex carbohydrates.

The capsule also contains inactive ingredients—cellulose, silicon dioxide, and magnesium stearate—which are typical fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support nutrient absorption and improve digestion.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Rhinosinusitis — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Rhinosinusitis, Postoperative swelling, and more.

The evidence for most conditions this product may be marketed for is insufficient. Bromelain is studied for hay fever, burns, cancer, chemotherapy side effects, vein health, and diabetes, but reliable evidence to rate it for these uses isn't established in our data.

Lactase, however, is rated effective for lactose intolerance—that's its proven role. Lipase and the protease are studied for digestive issues and inflammatory bowel disease, but the evidence remains insufficient to rate them.

The other enzymes in the blend don't have effectiveness ratings on file.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Overall, the enzyme blend is generally well tolerated when used as directed. Bromelain may cause diarrhea, flatulence, gastric upset, or headache when taken by mouth.

Allergic reactions (including asthma if inhaled) can occur, particularly in people sensitive to pineapple or with occupational enzyme exposure. Lactase has one reported case of allergic reaction but is otherwise well tolerated.

Lipase and proteases are well tolerated in supplement form for most adults, though no adverse effects have been formally documented for lipase. Long-term safety data for bromelain is limited.

During pregnancy, bromelain is best avoided due to insufficient safety data; lactase is likely safe but check with your doctor first; lipase and proteases have little pregnancy data, so medical advice is recommended. Breastfeeding safety is unknown for bromelain and proteases, and limited for lipase—all warrant a conversation with your healthcare provider.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking 9-Zymes, double-check if you're on blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin)—bromelain may increase bleeding risk (Moderate severity). If you take tetracycline antibiotics, note there's a minor interaction with bromelain.

No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

9-Zymes is a digestive enzyme blend most suitable for people looking to support general digestion or manage lactose intolerance (lactase is effective for that). If you take blood thinners, antiplatelet drugs, or tetracycline antibiotics, check with your pharmacist first—bromelain may interact.

Pregnant and breastfeeding individuals should talk to their doctor or pharmacist before starting, since safety data is incomplete or limited for most of these enzymes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 9-Zymes, straight from the product label.

Brand Cutler Nutrition
Barcode (UPC) 850002859393
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275688
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 9-Zymes by Cutler Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
120
UPC/BARCODE
850002859393
IngredientAmount% DV
Bromelain0 NP--
Lactase40 ALU--
Digestive Enzyme Blend500 mg--
Lipase0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Breakdown of Proteins0 NP--
Vegetal Analog of Pancreatin0 NP--
acid-stable Protease0 NP--
Breakdown Fats0 NP--
Alpha-Amylase0 NP--
Amyloglucosidase0 NP--
Breakdown Fiber0 NP--
Breakdown Milk Sugars0 NP--

Other ingredients: Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Enzyme [en-zahym]: Various proteins capable of producing certain chemical changes in organic substances by catalytic action, such as digestion. You are what you absorb - not what you eat, and unfortunately the readily available processed foods we reach for when we're short on time are devoid of the naturally occurring digestive enzymes we need to properly assimilate our nutrients. 9-zymes contains nine key enzymes to help break down the protein, carbs and fats we eat for easier digestions, improved nutrient absorption, and reduced abdominal bloating.

Vegan-friendly formula

Support nutrient absorption Improve digestion

Comprehensive Digestive enzyme matrix

Support gut health & digestion

Precautions

Warning: Not intended for persons under the age of 18.

Do not exceed recommended dose. Do not consume caffeine from other sources. Do not use for more than 8 weeks continuously. Read the entire label and consult your physician prior to use.

Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, diabetes, high blood pressure, or cardiac arrhythmia; or if you are pregnant, nursing, or have a medical condition, or are taking any medications such as MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti inflammatory drugs or products.

Do not use if product has been opened or tampered with in any other way.

Keep out of reach of children.

Allergen warning: Made in a facility that processes soy, egg, peanuts, tree nuts, fish, shellfish, and wheat products.

Storage

Store in a cool, dry place.

Seals/Symbols

GMP Quality

Manufactured in the USA using domestic & imported ingredients

Brand IP Statement(s)

Cutler Nutrition Train Like a Pro

Formula

9 enzymes per capsule

Includes lactase for lactose support

General Statements

Pro approved

X002MN3641

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: As a dietary supplement, take one serving (1 capsule) with each meal. Do not exceed more than 5 capsules in a 24-hour period.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

9-Zymes by Cutler Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

9-Zymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 9-Zymes by Cutler Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Digestive Enzyme Blend

500 mg per serving
  • › Breakdown of Proteins
  • › Breakdown Fats
  • › Breakdown Fiber
  • › Breakdown Milk Sugars

Other (inactive) ingredients: Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

9-Zymes by Cutler Nutrition Drug Interactions

Want to check YOUR meds against 9-Zymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in 9-Zymes interact with 141 drugs. Click any drug to see the details.

0 of the 4 ingredients in 9-Zymes interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in 9-Zymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for 9-Zymes, from the product label.

Cutler Nutrition

See all Cutler Nutrition products
Name
Cutler Nutrition
Street Address
3625 W Teco Ave Suite 5
City
Las Vegas
State
NV
ZipCode
89118
Web Address
www.JAYCUTLER.com
Pharmacist Counseling Corner

9-Zymes by Cutler Nutrition: Common Questions

Does 9-Zymes by Cutler Nutrition interact with any medications?
Yes. Based on its ingredients, 9-Zymes has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
9-Zymes contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
Bromelain should be avoided during pregnancy because there isn't enough safety data. Lactase is likely safe in pregnancy, but check with your doctor first. Lipase and proteases have little data in pregnancy and breastfeeding—talk to your healthcare provider before use.
What does this product actually do?
It's a blend of digestive enzymes that help break down proteins, fats, carbohydrates, and fiber in food. Lactase specifically is proven effective for lactose intolerance. The evidence for the other enzymes helping with specific conditions isn't established in our data.
Can bromelain cause allergic reactions?
Yes. Allergic reactions to bromelain can happen, including rash, hives, and throat itching. If bromelain is inhaled (occupational exposure), it may cause asthma. If you have a pineapple allergy, let your pharmacist know.
What side effects might I experience?
Bromelain may cause diarrhea, gas, stomach upset, or headache. Allergic reactions are possible but uncommon. The other enzymes are generally well tolerated, with little to no documented side effects in adults.
How long can I take this safely?
Short-term use of bromelain appears well tolerated, but long-term safety data is limited. For the other enzymes, safety data is also incomplete. If you plan regular long-term use, talk to your healthcare provider.
Does this interact with pain relievers like ibuprofen or naproxen?
There's one case report of minor bruising when bromelain was taken with naproxen. If you use these together, be alert for unusual bruising or bleeding and contact your doctor if it occurs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 9-Zymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

9-Zymes label
Sources

Sources & How We Checked

9-Zymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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