Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

A.M.P.'D UP Ingredients & Drug Interactions

by i-Prevail Supplements

A.M.P.'D UP label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking A.M.P.'D UP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

A.M.P.'D UP is a dietary supplement by i-Prevail Supplements with 4 active ingredients. Its ingredients are commonly taken for muscle building and strength, bodybuilding 'prohormone' supplement, boosting androgen/dht levels.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against A.M.P.'D UP by i-Prevail Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with A.M.P.'D UP by i-Prevail Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of A.M.P.'D UP by i-Prevail Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

A.M.P.'D UP contains 4 active ingredients: Epiandrosterone, Tongkat Ali (Eurycoma longifolia root extract), Naringen, and Laxopure (a laxogenin-derived compound). These are combined with inactive ingredients — the capsule shell, dicalcium phosphate, and magnesium stearate — which serve as binding and flow agents.

Epiandrosterone and Tongkat Ali are both hormone-related compounds meant to support testosterone levels and athletic or sexual function, while Laxopure is a plant-derived steroid compound. Naringen is a citrus flavonoid.

The product positions itself as a performance and vitality support formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Androgen metabolism and male hormone support.
  • We looked for evidence on: Age-related testosterone deficiency, Male Infertility, Sexual desire, Erectile dysfunction (ED), Muscle strength, Athletic performance — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence for A.M.P.'D UP's ingredients is limited. Tongkat Ali is rated possibly effective for sexual desire, but the other ingredients lack sufficient evidence to establish their benefit.

Epiandrosterone, for instance, shows insufficient reliable evidence for athletic performance, muscle strength, erectile dysfunction, sexual arousal, or obesity. Laxopure has no effectiveness data on file.

Because most of this product's claims lack solid evidence, talk with your doctor or pharmacist about whether it's right for your goals.

The evidence, ingredient by ingredient Epiandrosterone Eurycoma Longifolia Laxogenin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Epiandrosterone is a hormone-related supplement with limited safety data and real potential for androgenic side effects — meaning effects linked to male hormones, such as acne, mood changes, or hair growth. Tongkat Ali is generally tolerated short-term in studies, but long-term safety and product quality are uncertain.

Both ingredients carry risks if testosterone is pushed beyond normal ranges, including acne, insulin resistance, and liver stress. Laxopure has very limited human safety data and widely variable product quality.

Neither this product nor any of its ingredients should be used during pregnancy or while breastfeeding — there is insufficient or no safety data for each.

Side effects, ingredient by ingredient Epiandrosterone Eurycoma Longifolia Laxogenin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take A.M.P.'D UP, check with your doctor or pharmacist if you use propranolol or other beta-blockers — this product may reduce their effectiveness. Also confirm any testosterone replacement therapy, medications metabolized through your liver (CYP1A2, CYP2C19, or CYP2A6 substrates), or hormone-sensitive medications.

Altogether, these interactions span 248 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

A.M.P.'D UP is a hormone-support formula with considerable interaction potential and limited evidence of effectiveness. If you take propranolol, any blood-pressure or heart medications, testosterone therapy, or drugs your liver processes, you need to check this product against your medications before starting.

Anyone pregnant, breastfeeding, or with hormone-sensitive health conditions should talk with their doctor or pharmacist before considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about A.M.P.'D UP, straight from the product label.

Brand i-Prevail Supplements
Net contents 0 Not Present
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228497
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for A.M.P.'D UP by i-Prevail Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Naringen200 mg--
Epiandrosterone200 mg--
Tongkat Ali200 mg--
Laxopure75 mg--

Other ingredients: Capsule Shell, Dicalcium Phosphate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Andro Metabolite Protagonist

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

A.M.P.'D UP by i-Prevail Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

A.M.P.'D UP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in A.M.P.'D UP by i-Prevail Supplements

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Naringen

200 mg per serving

Epiandrosterone

No known
interactions
200 mg per serving

Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic perfor...

Epiandrosterone monograph & interactions

Tongkat Ali

Interacts with
248 drugs
200 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali monograph & interactions

Laxopure

No known
interactions
75 mg per serving

Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human resear...

Laxopure monograph & interactions

Other (inactive) ingredients: Capsule Shell, Dicalcium Phosphate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

A.M.P.'D UP by i-Prevail Supplements Drug Interactions

Want to check YOUR meds against A.M.P.'D UP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali 248

Individual Drug Interactions

The ingredients in A.M.P.'D UP interact with 248 drugs. Click any drug to see the details.

1 of the 4 ingredients in A.M.P.'D UP interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali

Each ingredient & the kinds of drugs it affects

For each ingredient in A.M.P.'D UP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali full monograph & interactions
The maker

Brand information

Manufacturer and brand details for A.M.P.'D UP, from the product label.

i-Prevail Supplements

See all i-Prevail Supplements products
Name
i-Prevail Supplements
Pharmacist Counseling Corner

A.M.P.'D UP by i-Prevail Supplements: Common Questions

Does A.M.P.'D UP by i-Prevail Supplements interact with any medications?
Yes. Based on its ingredients, A.M.P.'D UP has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
A.M.P.'D UP contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Epiandrosterone should not be used during pregnancy, and there's no safety data for it or any other ingredient in this product while breastfeeding. Talk with your doctor or pharmacist about what's safe for you.
Does this product actually work for muscle or athletic performance?
There isn't enough evidence to say. Epiandrosterone and Laxopure both lack reliable evidence for athletic performance or muscle strength. Tongkat Ali is possibly effective for sexual desire, but the research on performance is limited.
What are the side effects I should watch for?
If testosterone levels rise above normal, you might see acne, changes in mood or behavior, or insulin resistance. Epiandrosterone has real potential for androgenic side effects because it's a hormone-related compound. Long-term safety is uncertain because research is limited.
What is Tongkat Ali, and why is it in this product?
Tongkat Ali is a root extract from Southeast Asian plants, added to support testosterone and sexual function. It's possibly effective for sexual desire, though it can interact with heart medications and liver-processed drugs, so it's important you check it against what you're taking.
What's the difference between the active and inactive ingredients?
The 4 active ingredients — Epiandrosterone, Tongkat Ali, Naringen, and Laxopure — are meant to produce an effect on your body. The inactive ones (capsule shell, dicalcium phosphate, magnesium stearate) are fillers and binders that hold the formula together.
I take propranolol. Can I use this product?
Not without talking to your doctor first. Tongkat Ali can reduce propranolol's levels by about 29%, which may lower its effectiveness for your heart or blood pressure. Check with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

A.M.P.'D UP label
Go deeper

The Full Monographs Behind A.M.P.'D UP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Epiandrosterone

Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic performance. There is very little high-quality...

Read the full Epiandrosterone monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Laxogenin

Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human research to show it actually works. Because pr...

Read the full Laxogenin monograph →
Sources

Sources & How We Checked

A.M.P.'D UP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Epiandrosterone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Epiandrosterone monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Laxogenin 3 references
  1. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Laxogenin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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