Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Activated Broccoli Ingredients & Drug Interactions

by NOW

Activated Broccoli label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Activated Broccoli against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Activated Broccoli is a dietary supplement by NOW with 2 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are TrueBroc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Activated Broccoli by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Activated Broccoli by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Activated Broccoli by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: broccoli extract (marketed as TrueBroc) and mustard. Broccoli is rich in compounds called glucosinolates, which may support cellular health.

The product also includes inactive ingredients — hypromellose, MCT oil, silicon dioxide, and stearic acid — which serve as capsule material, preservative, and filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy aging and neutralize free radicals.
  • We looked for evidence on: Breast cancer, Colorectal cancer, Gastric cancer, Prostate cancer, Antioxidant support, Cellular health — and 1 related terms.
  • The strongest evidence on file: Broccoli is rated "Possibly Effective" for Colorectal cancer (Natural Medicines).
  • Also on file: Broccoli is rated "Insufficient Reliable Evidence To Rate" for Breast cancer, Gastric cancer, Prostate cancer.

Broccoli is possibly effective for colorectal cancer based on the evidence we hold. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the evidence is insufficient to rate — meaning we don't have enough reliable data yet to say whether it works for those purposes.

We have no effectiveness data on file for mustard.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is generally well tolerated. However, this product is a concentrated supplement, and the safety of concentrated broccoli extracts is not as well established as eating fresh broccoli.

The safety notes advise avoiding concentrated supplements unless your doctor approves. Some people have reported loose stools, diarrhea, abdominal pain, and cramping after taking broccoli seed and sprout extracts, particularly at higher doses.

Allergic contact reactions have also been documented with broccoli.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on any drugs metabolized by CYP2A6 or CYP1A2 — broccoli can noticeably speed up how your body breaks these down, lowering their effectiveness. The interaction severity for both is Moderate.

Use the medication checker on this page to look up your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in colorectal cancer support and have discussed it with your doctor — but only if you're not taking medications broken down by your liver's CYP1A2 or CYP2A6 enzymes, which cover a lot of common drugs. Talk with your pharmacist or doctor before starting, especially if you're on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Activated Broccoli, straight from the product label.

Brand NOW
Barcode (UPC) 733739026217
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 266863
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Activated Broccoli by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
733739026217
IngredientAmount% DV
TrueBroc230 mg--
Mustard25 mg--

Other ingredients: Hypromellose, MCT Oil, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule daily.

Formula

NOW Activated Broccoli features TrueBroc, an ingredient that has 13% glucoraphanin from broccoli seed. Glucoraphanin works indirectly by activating enzymes that neutralize free radicals to support healthy aging. It also enhances the body's ability to detoxify metabolites and pollutants encountered in everyday life. These effects are long-lasting, with cellular health benefits that last up to 72 hours. Mustard seed powder possesses the enzyme myrosinase and is included to trigger the conversion in the body necessary to activate and maximize beneficial effects.

Enzyme activated broccoli extract 30 mg glucoraphanin

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Sulforaphane and there broccoli compounds may interact with metabolism of certain drugs. Consult a physician if pregnant/nursing, taking medication, or have a medical condition (especially thyroid disorders).

Keep out of the reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

Seals/Symbols

GMP quality assured

Formulation

Detoxification support Supports cellular and liver health

Vegetarian/Vegan

Non-GMO

Made and quality tested in the USA with globally sourced ingredients.

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

General Statements

General health Family owned since 1968.

Brand IP Statement(s)

TrueBroc is a registered trademark of Brassica Protection Products.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Activated Broccoli by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Activated Broccoli label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Activated Broccoli by NOW

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

TrueBroc

Interacts with
187 drugs
230 mg per serving Form: Broccoli

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

Mustard

25 mg per serving Form: Brassica hirta

Other (inactive) ingredients: Hypromellose, MCT Oil, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Activated Broccoli by NOW Drug Interactions

Want to check YOUR meds against Activated Broccoli?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

TrueBroc 187

Individual Drug Interactions

The ingredients in Activated Broccoli interact with 187 drugs. Click any drug to see the details.

1 of the 2 ingredients in Activated Broccoli interact with drugs. Each result below shows which ingredient is responsible. TrueBroc

Each ingredient & the kinds of drugs it affects

For each ingredient in Activated Broccoli with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Activated Broccoli, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Activated Broccoli by NOW: Common Questions

Does Activated Broccoli by NOW interact with any medications?
Yes. Based on its ingredients, Activated Broccoli has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Activated Broccoli contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Broccoli as a food is rated likely safe during pregnancy and lactation. However, this is a concentrated supplement, and the safety data we hold doesn't specifically address concentrated extracts in pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice.
Can broccoli really slow down how my medications work?
Yes — broccoli can increase the activity of two liver enzymes (CYP1A2 and CYP2A6) that break down many medications. Research shows eating 500 grams of fresh broccoli daily can boost these enzymes by 10% to 550%. A concentrated supplement may have a similar effect, which is why checking your specific drugs matters.
What side effects should I watch for?
The most common side effects reported with broccoli extracts are loose stools, diarrhea, abdominal pain, and cramping — particularly at higher doses. Allergic skin reactions have also been documented, though they're less common.
Does this product actually work for cancer prevention?
Broccoli is possibly effective for colorectal cancer based on the evidence we have. For other cancers like bladder, breast, and gastric cancer, the evidence isn't strong enough yet to rate whether it works.
Why can't you check the mustard ingredient for interactions?
We don't hold any interaction data for mustard in our system, so we can't tell you whether it interacts with medications. If you have questions about it specifically, ask your pharmacist.
Is concentrated broccoli as safe as eating broccoli at dinner?
Fresh broccoli as food is safe in normal amounts. Concentrated supplements are less studied, and the safety data we hold advises against them unless your doctor approves — so it's worth talking it over before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Activated Broccoli is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Activated Broccoli label
Go deeper

The Full Monographs Behind Activated Broccoli’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Activated Broccoli's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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