Interactions on record — worth a quick check against your medications. Based on 5 of 18 ingredients. Check your meds →
Dietary supplement

Advanced Adult Enzyme Blend Ingredients & Drug Interactions

by Flora Udo's Choice

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Advanced Adult Enzyme Blend is a dietary supplement by Flora Udo's Choice with 18 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Advanced Adult Enzyme Blend by Flora Udo's Choice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 18 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (280.70 mg) without saying how much of each component you get.

This blend contains 18 ingredients, most of them digestive enzymes. The active components include bromelain (from pineapple), lipase (breaks down fats), lactase (breaks down milk sugar), and several proteolytic enzymes—proteases that break down proteins.

You'll also find phytase and other carbohydrate-digesting enzymes like diastase and glucoamylase. The remaining ingredients are inactive—microcrystalline cellulose, magnesium stearate, maltodextrin, water, and the capsule material hydroxypropylmethylcellulose.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and nutrient absorption.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Allergic rhinitis (hay fever) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Rhinosinusitis, Postoperative swelling.

Evidence for this product's effectiveness is limited. Bromelain alone has insufficient reliable evidence for conditions like hay fever, burns, chronic venous insufficiency, and diabetes.

Lactase is effective for lactose intolerance—that's well established. For the other ingredients—lipase, phytase, and the proteases—the data we hold either shows insufficient evidence or no effectiveness ratings at all.

If you're considering this for a specific digestive or health concern, talk with your pharmacist or doctor about what the research actually supports.

The evidence, ingredient by ingredient Bromelain Lipase Lactase Phytase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, though long-term safety data are sparse. It may cause diarrhea, flatulence, stomach upset, or headache.

Allergic reactions (including asthma and throat itching) can occur, especially if you inhale the powder. Lipase and lactase are generally well tolerated; no adverse effects have been reported for lipase in adults.

The proteolytic enzymes may cause digestive upset or allergic reactions in some people. Phytase has limited human supplement safety data, though occupational exposure to airborne phytase has triggered allergic asthma and hypersensitivity reactions in animal-feed workers.

Side effects, ingredient by ingredient Bromelain Lipase Lactase Phytase Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, aspirin, or clopidogrel, double-check with your pharmacist—bromelain may increase bleeding risk (Moderate severity). Also verify if you're on a tetracycline antibiotic, since bromelain may affect how your body handles it (Minor severity).

For any other prescription medication, run it through the checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme blend is reasonable for digestive support if you're not on blood thinners or tetracycline antibiotics. If you take warfarin, aspirin, clopidogrel, or a tetracycline antibiotic, check with us first—the interaction risk is real.

Bromelain isn't recommended in pregnancy or while breastfeeding; safety data for several other ingredients during pregnancy and nursing are thin or missing. Talk to your pharmacist about whether this fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Adult Enzyme Blend, straight from the product label.

Brand Flora Udo's Choice
Barcode (UPC) 061998613795
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 304749
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Seniors/Mature (>50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Adult Enzyme Blend by Flora Udo's Choice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
061998613795
IngredientAmount% DV
Proprietary Blend280.7 mg--
Amylase0 NP--
Bromelain0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Beta-Glucanase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Diastase0 NP--
Protease 4.50 NP--
Protease 30 NP--
Protease 60 NP--
Alpha-Galactosidase0 NP--
Protease0 NP--
Protease0 NP--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin, Water, Hydroxypropylmethylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Udo's Choice Advanced Adult Enzyme Blend was formulated for people seeking extra digestive support - especially individuals 65 years or older. This is because our ability to digest food and absorb nutrients decreases with age.

Formulation

This full-spectrum vegetarian enzyme blend is our most potent formula to aid in the healthy digestion of fats, proteins, soluble fiber, and carbohydrates - even the milk sugars and proteins found in dairy products.

This blend also helps maximize the absorption of important nutrients such as calcium.

Enhances proper digestion and absorption of nutrients Plant source

Product of Canada

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Udo Erasmus

Printed in Canada

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take one capsule at the beginning of each meal. For heavy meals, take an additional capsule in the middle of the meal.

Storage

Store in a cool, dry place.

Precautions

Keep out of the reach of children.

Caution: Enzymes are heat sensitive. Do not take them with very hot items. May irritate an existing ulcer. Security sealed for your protection. Do not use if seal is missing or damaged.

See for yourself

Advanced Adult Enzyme Blend by Flora Udo's Choice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Advanced Adult Enzyme Blend by Flora Udo's Choice

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

280.7 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin, Water, Hydroxypropylmethylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Adult Enzyme Blend by Flora Udo's Choice Drug Interactions

Want to check YOUR meds against Advanced Adult Enzyme Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Adult Enzyme Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Advanced Adult Enzyme Blend, from the product label.

Flora Udo's Choice

See all Flora Udo's Choice products
Name
Flora, Inc.
Street Address
805 E. Badger Rd.
City
Lynden
State
WA
ZipCode
98264
Phone Number
1.800.446.2110
Web Address
www.florahealth.com
Pharmacist Counseling Corner

Advanced Adult Enzyme Blend by Flora Udo's Choice: Common Questions

Does Advanced Adult Enzyme Blend by Flora Udo's Choice interact with any medications?
Yes. Based on its ingredients, Advanced Adult Enzyme Blend has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Adult Enzyme Blend contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Bromelain is not recommended during pregnancy—there isn't enough safety data. Lactase is likely safe, but lipase, phytase, and the proteases all have insufficient safety data in pregnancy. Talk with your doctor before starting, especially if you're planning to use it regularly.
Is this safe while breastfeeding?
Safety while breastfeeding hasn't been well studied for most of these enzymes. Bromelain should be avoided. For the others—lipase, phytase, and the proteases—there's little data, so check with your doctor or pharmacist first.
What are the most common side effects?
Bromelain may cause diarrhea, flatulence, stomach upset, or headache. The enzymes overall are generally well tolerated, but digestive upset or allergic reactions are possible. If you develop asthma, throat itching, or other allergy symptoms, stop and contact us.
Will this help my lactose intolerance?
Lactase, one of the enzymes in this blend, is effective for lactose intolerance. The other enzymes don't have established evidence for specific conditions, so this blend's full benefit for you depends on what you're looking to address.
Does this have any fillers?
Yes. The inactive ingredients include microcrystalline cellulose, magnesium stearate, maltodextrin, water, and hydroxypropylmethylcellulose (the capsule material).
Can I take this with my pain reliever?
If your pain reliever is naproxen, there's a case report of minor bruising when combined with bromelain, so check with your pharmacist. For other pain medications, it depends on the specific drug—use the checker on this page with your exact medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Adult Enzyme Blend is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Adult Enzyme Blend label
Go deeper

The Full Monographs Behind Advanced Adult Enzyme Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Advanced Adult Enzyme Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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