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Dietary supplement

Advanced Hair + Nail Care Ingredients & Drug Interactions

by Biosil

Capsule Category: Other Combinations
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Advanced Hair + Nail Care is a dietary supplement by Biosil with 3 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Advanced Hair + Nail Care by Biosil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Biosil Advanced Hair + Nail Care has 3 active ingredients. Biotin is a B vitamin that supports hair and nails and is likely effective for biotin deficiency.

Choline is an essential nutrient involved in cell structure and brain function. Silicon is a mineral that may support bone and connective tissue health.

The product also contains inactive ingredients (fillers and capsule material) including microcrystalline cellulose, purified water, hypromellose, and carrot concentrate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Hair, nail growth, strength and thickness.
  • We looked for evidence on: Alopecia areata, Androgenic alopecia, Biotin deficiency, Brittle nails, Hair loss, Nail brittleness — and 2 related terms.
  • The strongest evidence on file: Biotin is rated "Likely Effective" for Biotin deficiency (Natural Medicines).
  • Also on file: Biotin is rated "Insufficient Reliable Evidence To Rate" for Alopecia areata, Brittle nails.
  • Also on file: Silicon is rated "Insufficient Reliable Evidence To Rate" for Androgenic alopecia.

Biotin is likely effective for treating biotin deficiency. For hair and nail health specifically, the evidence in our data is limited—we don't have an effectiveness rating for those uses.

Choline and silicon don't have established evidence for hair or nail health in the data we hold. If you're taking this product for a specific condition like hair loss or weak nails, ask your pharmacist whether the evidence supports it for what you're after.

The evidence, ingredient by ingredient Biotin Choline Silicon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at fairly high doses, because your body removes excess in the urine. Very rarely, high-dose biotin (like 300 mg daily) has caused mild diarrhea.

Choline is safe in food amounts, but high-dose supplements can cause side effects—doses over 3.5 grams daily may cause fishy body odor, diarrhea, nausea, and vomiting. Silicon from food and typical supplements is well tolerated; long-term safety at high doses hasn't been well studied.

For pregnancy, biotin and choline are likely safe, but silicon safety data is limited—check with your doctor. For breastfeeding, choline needs are higher and should be used only under professional guidance; silicon safety while breastfeeding has not been established.

Side effects, ingredient by ingredient Biotin Choline Silicon

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take atropine (Minor interaction with choline—it may theoretically reduce atropine's effects). No other interactions are documented for the biotin and silicon in this product, but it's still worth running your full medication list through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is generally well tolerated for hair and nail support. If you take atropine or any other medications, check them with the tool below before starting.

Talk to your pharmacist if you're pregnant or breastfeeding, especially about the silicon content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Hair + Nail Care, straight from the product label.

Brand Biosil
Barcode (UPC) 5425010390739
Net contents 180 Original Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334674
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Hair + Nail Care by Biosil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
5425010390739
IngredientAmount% DV
Biotin65 mcg217%
Choline100 mg18%
Silicon5 mg--

Other ingredients: Microcrystalline Cellulose, Water, Purified, Hypromellose, Carrot Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

ch-OSA Original Complex

Clinically proven ch-OSA + Biotin

Capsule shell consists of hypromellose and carrot concentrate.

Brand IP Statement(s)

Copyright 2022 Bio Minerals NV U.S. Patents 7,968,528 and 8,771,757

ch-OSA, Biosil and the Vegan logo are registered trademarks of Bio Minerals N.V.

Formulation

+ Growth + Strengthen + Thicken Added biotin takes your hair + nails to a new level. Biotin is an essential nutrient that supports healthy metabolism (vital for healthy hair and nails). ch-OSA complex helps link keratin fibers together for stronger hair and nails. Together they form a powerful combination for more & thicker hair, stronger nails, and healthy skin.

2 in 1 generates + protects your own collagen

Vegan Friendly Supplement This product is V Vegan Friendly

This product does not contain soy, dairy, egg, corn, wheat, gluten, fish/shellfish, nuts/tree nuts.

2 in 1 Generate + Protect Biosil's ch-OSA complex activates your natural ability to generate and protect your own collagen, elastin, and keratin. This improves and supports your hair, skin, nails. Biotin enhances the benefits of the ch-OSA complex - especially keratin production - for thick, lustorous hair & strong nails.

Gluten & Allergen Free GMO Free Soy Free Dairy Free

Vegan Friendly

Clinical Facts ch-OSA complex Clinically Proven Dosage 1 capsule, 2 times daily Clinically Proven for Skin Clinically Proven for Hair Clinically Proven for Nails ch-OSA complex has been tested in rigorous double-blind placebo controlled clinical trials for both efficacy and safety. The results are published in peer reviewed medical journals.

General Statements

Learn More

FDA Statement of Identity

Vegan Friendly Supplement

Seals/Symbols

V Vegan

Vegan Friendly

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 2 times daily.

Precautions

Consult your healthcare professional prior to use if you have, or suspect a medical condition or are taking prescription drugs.

Keep out of the reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure or prevent any disease.

Storage

Store at 59 - 86 Degrees F (15 - 30 Degrees C). Protect from light and moisture.

See for yourself

Advanced Hair + Nail Care by Biosil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Advanced Hair + Nail Care by Biosil

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
65 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Choline

Interacts with
16 drugs
100 mg per serving Form: ch-OSA

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Silicon

No known
interactions
5 mg per serving Form: ch-OSA

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silicon monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Water, Purified, Hypromellose, Carrot Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Hair + Nail Care by Biosil Drug Interactions

Want to check YOUR meds against Advanced Hair + Nail Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Hair + Nail Care with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Advanced Hair + Nail Care, from the product label.

Biosil

Name
Bio Minerals NV
Street Address
Zenderstraat 12
State
Destelbergen
ZipCode
B-9070
Web Address
www.biosil.beauty
Pharmacist Counseling Corner

Advanced Hair + Nail Care by Biosil: Common Questions

Does Advanced Hair + Nail Care by Biosil interact with any medications?
Yes. Based on its ingredients, Advanced Hair + Nail Care has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Hair + Nail Care contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will biotin actually help my hair and nails grow?
Biotin is likely effective for biotin deficiency, but we don't have established evidence in our data specifically for hair and nail growth in otherwise healthy people. That doesn't mean it won't help—just that the science isn't settled yet in the data we hold. Ask your pharmacist if it's worth trying for your situation.
Is it safe to take this if I'm pregnant?
Biotin and choline are likely safe in pregnancy. Silicon's safety during pregnancy hasn't been well studied, so talk with your doctor before taking a product containing it while pregnant.
What's the fishy smell I've heard about with choline?
At high doses, choline can cause a fishy body odor because your gut bacteria break it down into trimethylamine. The doses in this product are likely lower than what would cause that, but if it happens, it's harmless—just uncomfortable.
Can I take this long-term?
Biotin and choline are well tolerated over time. Silicon's long-term safety at supplement doses hasn't been thoroughly studied, so check with your pharmacist if you're planning to take this for months or years.
Is this product tested to help with alopecia (hair loss)?
We don't have enough reliable evidence in our data to rate whether biotin or silicon actually works for hair loss. If you're dealing with alopecia, ask your pharmacist or doctor whether this product is worth trying for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Hair + Nail Care is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Hair + Nail Care label
Sources

Sources & How We Checked

Advanced Hair + Nail Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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