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Dietary supplement

Advanced Therapeutics Huperzine Rx-Brain Ingredients & Drug Interactions

by NaturesPlus

Advanced Therapeutics Huperzine Rx-Brain label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Therapeutics Huperzine Rx-Brain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Therapeutics Huperzine Rx-Brain is a dietary supplement by NaturesPlus with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, alzheimer's disease and dementia, age-related memory decline.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: huperzine A, a compound extracted from club moss plants. Huperzine A works by blocking an enzyme (acetylcholinesterase) that normally breaks down acetylcholine, a chemical messenger in your brain.

The inactive ingredients are dicalcium phosphate, microcrystalline cellulose, cellulose, stearic acid, magnesium stearate, silica, and pharmaceutical glaze — these are standard tablet binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: nutritional support for optimal brain function.
  • We looked for evidence on: Alzheimer disease, Cognitive impairment, Memory, Vascular dementia, Age-related cognitive decline, Mental clarity — and 1 related terms.
  • The strongest evidence on file: Huperzine A is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Cognitive impairment, Vascular dementia, Memory.

Huperzine A is rated possibly effective for Alzheimer disease based on available evidence. For athletic performance, cognitive impairment, vascular dementia (stroke-related dementia), depression, and memory, the evidence we hold is insufficient to rate whether it works.

If you're considering this for any of those other uses, talk with your pharmacist or doctor about what the research actually shows.

The evidence, ingredient by ingredient Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, huperzine A is generally well tolerated, though it's a pharmacologically active compound and does carry real side effects. The most common are cholinergic effects — blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, and vomiting.

These tend to be dose-dependent, meaning higher doses bring more risk. There are also rare reports of decreased heart rate.

Because not enough safety data exists, huperzine A is best avoided during pregnancy and while breastfeeding. Use it only under medical guidance.

Side effects, ingredient by ingredient Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Huperzine A.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before you start, especially cholinergic drugs (those that boost acetylcholine, like certain Parkinson's or Alzheimer's medications) and anticholinergic drugs (medications for overactive bladder, nerve pain, or muscle spasms). Both categories carry Moderate interaction risk with huperzine A.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is for people interested in Alzheimer disease support, but it's a real pharmaceutical compound — not a gentle herb. If you take any prescription medications, especially for nerve or muscle function, you must check them against this product first.

Talk with your pharmacist before starting, and watch for dizziness, nausea, or vision changes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Therapeutics Huperzine Rx-Brain, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467049819
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298225
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
097467049819
IngredientAmount% DV
Huperzine A50 mcg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Cellulose, Stearic Acid, Magnesium Stearate, Silica, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nutritional support for optimal brain function.

Free from artificial colors and preservatives. Free from all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Vegetarian.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Gluten free

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, one tablet daily with a meal or as recommended by your health care professional.

Precautions

Warnings: Do not take this product if you have heart or pulmonary problems without first consulting your physician.

Do not use if you are pregnant or lactating.

Keep out of reach of children.

Storage

Keep tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Huperzine-A-Supplement

Formula

Huperzine Rx-Brain is a precisely calibrated nutritional formulation born from leading-edge scientific studies and clinical evaluation. Each tablet provides pure huperzine-A, the active neuronutrient found in the rare species of Chinese moss, Huperzia serrata. Huperzine Rx-Brain is a unique specialty formula designed for any individual concerned with promoting optimal brain function.

Brand IP Statement(s)

Copyright Natural Organics

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Therapeutics Huperzine Rx-Brain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Huperzine A

Interacts with
219 drugs
50 mcg per serving Form: Huperzia serrata

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Cellulose, Stearic Acid, Magnesium Stearate, Silica, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus Drug Interactions

Want to check YOUR meds against Advanced Therapeutics Huperzine Rx-Brain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Huperzine A 219

Individual Drug Interactions

The ingredients in Advanced Therapeutics Huperzine Rx-Brain interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Advanced Therapeutics Huperzine Rx-Brain interact with drugs. Each result below shows which ingredient is responsible. Huperzine A

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Therapeutics Huperzine Rx-Brain with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Therapeutics Huperzine Rx-Brain, from the product label.

NaturesPlus

See all NaturesPlus products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus: Common Questions

Does Advanced Therapeutics Huperzine Rx-Brain by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Advanced Therapeutics Huperzine Rx-Brain has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Therapeutics Huperzine Rx-Brain contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does huperzine A actually do in my brain?
Huperzine A blocks an enzyme that normally breaks down acetylcholine, a chemical your brain uses for memory and thinking. By keeping acetylcholine around longer, it theoretically helps preserve mental function. It's a real pharmacological action, which is why interactions and side effects are possible.
Will this help my memory or focus?
We have insufficient evidence to say whether huperzine A actually works for memory or focus. It's rated possibly effective for Alzheimer disease, but for general memory or cognitive performance, the data we hold doesn't support a claim. Ask your pharmacist what clinical trials have shown.
Is it safe during pregnancy or breastfeeding?
No. There isn't enough safety data in pregnancy, so it's best avoided. Safety while breastfeeding is also unknown, so you should avoid it then too. If you're pregnant or nursing and interested in this product, talk with your doctor first.
What side effects should I watch for?
The most common are cholinergic effects from the way huperzine A works: blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, and vomiting. Less often, decreased heart rate has been reported. These tend to be dose-dependent — higher doses mean more risk.
Is this product safe to take with my medications?
That depends on exactly what you take. Huperzine A interacts with cholinergic drugs and anticholinergic drugs at a Moderate level. Use the interaction checker on this page with your specific prescriptions, and call us or your doctor if you have any questions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Therapeutics Huperzine Rx-Brain label
Go deeper

The Full Monographs Behind Advanced Therapeutics Huperzine Rx-Brain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Advanced Therapeutics Huperzine Rx-Brain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Huperzine A 13 references
  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

See these in context on the Huperzine A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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