No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

AOR Zymes Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Premium

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

AOR Zymes is a dietary supplement by AOR Advanced Orthomolecular Research Premium with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of AOR Zymes by AOR Advanced Orthomolecular Research Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Porcine Pancreatic Enzymes” is listed as a grouped ingredient — the label gives one combined amount (664 mg) without saying how much of each component you get.

AOR Zymes is a digestive enzyme blend with four active ingredients: amylase, protease, lipase, and alpha-galactosidase. Protease and lipase are the two for which we hold detailed data; both are enzymes that your body naturally produces to break down food.

The product also contains inactive ingredients — silicon dioxide, maltodextrin, sodium stearyl fumarate, and a capsule shell — which serve as fillers and binders to hold the formula together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: healthy digestion with pancreatic enzymes.
  • We looked for evidence on: Dyspepsia, pancreatic insufficiency, indigestion, malabsorption.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence we hold on these enzymes is limited. Lipase has been studied for inflammatory bowel disease and dyspepsia (indigestion), but the data was rated insufficient to say whether it works for those conditions.

We have no effectiveness ratings on file for protease, amylase, or alpha-galactosidase, so the strength of evidence for their specific uses isn't established in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated in most adults, though some people report digestive upset or allergic reactions. Protease can rarely trigger allergic responses — occupational exposure to airborne proteolytic enzymes has led to allergic rhinitis or asthma in case reports, and people sensitive to enzymes in laundry products may be at higher risk.

In pregnancy, the safety data advises against protease use unless your doctor prescribes it. For lipase in pregnancy, there isn't enough data to know either way, so talk with your doctor if you're pregnant or planning to be.

During breastfeeding, both protease and lipase have little safety data — check with your healthcare provider first. We don't have pregnancy or breastfeeding safety information on file for amylase or alpha-galactosidase.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check in this product. Even so, it's always smart to run your exact medications through the search tool on this page or confirm with your pharmacist before starting any new supplement.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

If you're looking for digestive support with enzyme blends, AOR Zymes is generally well tolerated by most adults and carries no documented medication interactions. That said, the effectiveness of these particular enzymes for specific digestive complaints hasn't been firmly established in the data we hold.

If you're pregnant, breastfeeding, or have a serious digestive condition, talk with your doctor or pharmacist before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AOR Zymes, straight from the product label.

Brand AOR Advanced Orthomolecular Research Premium
Barcode (UPC) 624917081091
Net contents 100 Gastric-Resistant Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214706
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AOR Zymes by AOR Advanced Orthomolecular Research Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
624917081091
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Alpha-Galactosidase1400 mg--
Porcine Pancreatic Enzymes664 mg--

Other ingredients: Silicon Dioxide, Maltodextrin, Capsule, Sodium Stearyl Fumarate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Pancreatic enzymes for healthy digestion

Gluten free

Absorbable

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, corn, soy, nuts, eggs, fish or shellfish.

Precautions

Do not use if safety seal is broken

Caution: Consult a health care practitioner if you are pregnant or breastfeeding, for prolonged use or for use beyond 4 weeks, if you have diabetes, pancreatitis, pancreatic exocrine insufficiency or cystic fibrosis.

Do not use if you are sensitive to pancreatic enzymes or pork proteins.

If symptoms persist or worsen, discontinue use and consult a health care practitioner.

Consult your physician before use if you have a medical condition, or are taking any medication.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place

Formula

Discussion: AOR Zymes is formulated with porcine derived pancreatic enzymes because they are similar to human pancreatic enzymes for healthy digestion.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule immediately before a meal one to four times daily, or as directed by a qualified health care practitioner. Use the smallest effective dose which controls symptoms. Swallow whole; do not open or chew capsules.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Product of Canada

See for yourself

AOR Zymes by AOR Advanced Orthomolecular Research Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in AOR Zymes by AOR Advanced Orthomolecular Research Premium

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Galactosidase

1400 mg per serving

Porcine Pancreatic Enzymes

664 mg per serving

Other (inactive) ingredients: Silicon Dioxide, Maltodextrin, Capsule, Sodium Stearyl Fumarate. These complete the product’s ingredient list but are not active constituents.

Interaction report

AOR Zymes by AOR Advanced Orthomolecular Research Premium Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in AOR Zymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for AOR Zymes, from the product label.

AOR Advanced Orthomolecular Research Premium

See all AOR Advanced Orthomolecular Research Premium products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

AOR Zymes by AOR Advanced Orthomolecular Research Premium: Common Questions

Does AOR Zymes by AOR Advanced Orthomolecular Research Premium interact with any medications?
We do not currently list a known interaction for the mapped ingredients in AOR Zymes. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
AOR Zymes contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my medications?
No interactions are documented in our data for the ingredients we could check — protease and lipase both carry no known drug interactions. We couldn't check amylase and alpha-galactosidase, so we hold no data for those. Use the search tool on this page to look up your specific medications, or ask your pharmacist to be sure.
Is it safe to take during pregnancy?
The safety data advises against protease in pregnancy unless your doctor prescribes it. For lipase, there isn't enough data to know either way — talk with your doctor if you're pregnant or planning to be. We don't have pregnancy safety information on file for amylase or alpha-galactosidase.
Is it safe while breastfeeding?
Both protease and lipase have little safety data during breastfeeding, so check with your healthcare provider first before using this product. We don't have breastfeeding safety information on file for amylase or alpha-galactosidase.
Can protease cause allergic reactions?
Protease is generally well tolerated, but allergic reactions are possible — especially if you're sensitive to enzymes in laundry products or have had occupational exposure to airborne enzymes. Some people report digestive upset. If you notice signs of an allergic reaction or severe digestive symptoms, stop and talk with your doctor.
Does this actually work for digestion?
Lipase has been studied for indigestion and inflammatory bowel disease, but the evidence was rated insufficient to say whether it's effective. We have no effectiveness data on file for the other three enzymes, so the strength of evidence for this blend's digestive benefits isn't established in our data.
What are the inactive ingredients?
The capsule contains silicon dioxide, maltodextrin, and sodium stearyl fumarate as fillers and binders, plus a capsule shell. If you have allergies or sensitivities to any of these, check the label or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AOR Zymes is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AOR Zymes label
Sources

Sources & How We Checked

AOR Zymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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