Ashwagandha Ingredients & Drug Interactions
by CHOQ
What is this page for?
First and foremost: checking Ashwagandha against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha is a dietary supplement by CHOQ with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Leaf, Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha by CHOQ
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ashwagandha by CHOQ
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
CHOQ Ashwagandha contains one active ingredient: Ashwagandha Leaf, Root Extract. The product also includes inactive ingredients—cellulose and rice—which serve as fillers and capsule material.
Does it work?
Moderate evidence
Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD) according to our data. The evidence for bipolar disorder is insufficient to rate.
If you're considering it for one of these uses, a conversation with your doctor can help you weigh whether a trial makes sense for your situation.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects—when they occur—are diarrhea, stomach upset, nausea, and vomiting, but these don't typically happen at standard doses.
Rare serious side effects include liver damage, hepatitis, and liver failure; one case report also described reversible cerebral vasoconstriction (a tightening of brain blood vessels) with associated bleeding. During pregnancy, ashwagandha is considered likely unsafe due to a traditional concern about miscarriage risk.
There isn't enough safety information to recommend it while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking it.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take hepatotoxic drugs (medicines that can affect liver function), CNS depressants, benzodiazepines, blood pressure medications, blood sugar medications, thyroid hormone, immunosuppressants, or any drug metabolized through the CYP1A2 pathway.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
CHOQ Ashwagandha may help with insomnia, anxiety, stress, and generalized anxiety disorder. If you take any medications—especially blood pressure drugs, blood sugar medications, sedatives, liver-metabolized drugs, or thyroid hormone—you'll need to check your specific medications against the interaction tool here and confirm with your doctor or pharmacist before starting.
Avoid it in pregnancy and while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha, straight from the product label.
| Brand | CHOQ |
|---|---|
| Barcode (UPC) | 643934452905 |
| Net contents | 30 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 315125 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha by CHOQ, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha Leaf, Root Extract | 300 mg | -- |
Other ingredients: Cellulose, Rice
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Pristinely sourced Premium grade
Non GMO
Vegan
Ultra concentrated & unmatched potency Supports healthy mood & focus Promotes healthy stress response Improves restorative sleep
You'd have to take 14 times as much of an average Ashwagandha to get the same amount of these critical compounds that's in just one capsule of CHOQ Ashwagandha.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water.
Precautions
Warning: For use by healthy adults only. Keep out of the reach of children.
Do not use if you are pregnant or nursing. Seek advice from a healthcare professional before taking if you have a preexisting medical condition.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
GMP Good Manufacturing Practice
Manufactured in USA
Brand IP Statement(s)
Shoden is a registered trademark of Arjuna Natural Pvt. Ltd.
General Statements
Youtube Choq Nation
FDA Statement of Identity
Dietary Supplement
Formula
CHOQ Ashwagandha is lab-verified to contain 35% withanolides, while most Ashwagandha supplements only contain 2.5%.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha by CHOQ label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha by CHOQ
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Ashwagandha Leaf, Root Extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha Leaf, Root Extract monograph & interactionsOther (inactive) ingredients: Cellulose, Rice. These complete the product’s ingredient list but are not active constituents.
Ashwagandha by CHOQ Drug Interactions
HelloPharmacist Interaction Report
CHOQ Ashwagandha has documented interactions with multiple medication types.
The most serious concern is with hepatotoxic drugs (those that can damage the liver)—ashwagandha has been linked to cases of acute hepatitis, liver failure, and in rare instances death from liver failure, so combining it with other drugs known to stress the liver requires caution.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions are documented with CNS depressants (sedatives, barbiturates, and anxiolytics), benzodiazepines, antihypertensive drugs, antidiabetes drugs, thyroid hormone, and immunosuppressants. CNS depressants and benzodiazepines may have their sedative effects increased.
Blood pressure medications and blood sugar drugs carry a theoretical risk of over-lowering your blood pressure or blood sugar, respectively. Ashwagandha may boost thyroid hormone effects and side effects.
Immunosuppressants (drugs that weaken your immune system intentionally, such as after transplant) may become less effective.
A minor interaction is documented with CYP1A2 substrates—a group of medications your liver metabolizes through one particular pathway—which ashwagandha may reduce in your bloodstream. Altogether, these interactions span 1,373 individual medications.
If you take any prescription medication, use the interaction checker on this page before starting ashwagandha, then confirm the results with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Leaf, Root Extract
Conjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Conjugated Estrogens interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Conjugated Estrogens, Methyltestosterone interactionCopanlisibAliqopa
How Copanlisib interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractImmunosuppressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Leaf, Root Extract + Copanlisib interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Leaf, Root Extract + Cortisone Acetate interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Leaf, Root Extract + Cryptenamine, Methyclothiazide interactionCyamemazineTercian
How Cyamemazine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Leaf, Root Extract + Cyamemazine interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Cyclophosphamide interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Cyclosporine interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Leaf, Root Extract + Cyclothiazide interactionDaclizumabZenapax, Zinbryta
How Daclizumab interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractImmunosuppressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Leaf, Root Extract + Daclizumab interactionDantroleneDantrium, Dantrium Intravenous
How Dantrolene interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Dantrolene interactionDantrolene SodiumRyanodex
How Dantrolene Sodium interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Dantrolene Sodium interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Leaf, Root Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Leaf, Root Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Leaf, Root Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Leaf, Root Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDapsoneAczone, Avlosulfon, Dapsone
How Dapsone interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Dapsone interactionDaridorexantQuviviq
How Daridorexant interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Daridorexant interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDasabuvir Sodium, Ombitasvir, Paritaprevir, RitonavirViekira XR
How Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Leaf, Root Extract + Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Leaf, Root Extract + Dasiglucagon Hydrochloride interactionDaunorubicin, CytarabineVyxeos
How Daunorubicin, Cytarabine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Daunorubicin, Cytarabine interactionDeferasiroxExjade, Jadenu
How Deferasirox interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Deferasirox interactionDeflazacortEmflaza
How Deflazacort interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractImmunosuppressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Leaf, Root Extract + Deflazacort interactionDehydrocholic Acid, Homatropine Methylbromide, PhenobarbitalG.B.S.
How Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha Leaf, Root Extract + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Leaf, Root Extract + Demeclocycline interactionDenosumabProlia, XGEVA
How Denosumab interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Leaf, Root Extract + Denosumab interactionDeserpidineHarmonyl
How Deserpidine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Leaf, Root Extract + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Leaf, Root Extract + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Leaf, Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Leaf, Root Extract + Deserpidine, Methyclothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha Leaf, Root Extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha, from the product label.
CHOQ
See all CHOQ products- Name
- CHOQ, LLC
- Street Address
- 1620 Cobb International Blvd NW Suite 5
- City
- Kennesaw
- State
- GA
- ZipCode
- 30152
- Phone Number
- 50-2467-3000
- Web Address
- Choq.com
Ashwagandha by CHOQ: Common Questions
Does Ashwagandha by CHOQ interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is ashwagandha safe to take long-term?
Can I take ashwagandha if I'm pregnant or breastfeeding?
What side effects might I notice?
Will ashwagandha help my anxiety?
Can ashwagandha affect my blood pressure or blood sugar?
What exactly is in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
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