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Dietary supplement

Astragalus Root Extract 300 mg Ingredients & Drug Interactions

by Vital Nutrients

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Astragalus Root Extract 300 mg is a dietary supplement by Vital Nutrients with 1 active ingredient. Its ingredients are commonly taken for immune support, colds and flu, upper respiratory infections.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astragalus Root Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Astragalus Root Extract 300 mg by Vital Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: astragalus root extract at 300 mg per capsule. Astragalus has been used in traditional medicine for centuries, and modern research has explored its potential effects on immune function and blood sugar regulation.

The capsule itself is filled out with inactive ingredients—cellulose, calcium carbonate, rice powder, silica, and leucine—which serve as binders and flow agents.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Astragalus product and its label doesn't state a use — see Astragalus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't show that astragalus is reliably effective for any single condition. For allergic rhinitis (hay fever), amenorrhea (absent menstrual periods), aplastic anemia, angina, asthma, and beta-thalassemia, the available data is insufficient to establish real benefit.

That doesn't mean it won't help you — it means the research so far hasn't been solid enough to say either way.

The evidence, ingredient by ingredient Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astragalus is generally well tolerated when taken short-term by healthy adults, but human safety data is limited. Some clinical trials have reported dizziness in a small number of participants, and one study noted a report of chest pain (though it's unclear if astragalus caused it).

Because there isn't enough reliable safety data, astragalus should be avoided during pregnancy and while breastfeeding — talk with your doctor or pharmacist about what's right for you if you're in either situation.

Side effects, ingredient by ingredient Astragalus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astragalus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this supplement, double-check with your doctor or pharmacist if you use immunosuppressant medications (like those after organ transplant), lithium (for bipolar disorder or depression), cyclophosphamide (chemotherapy), or diabetes medications. All carry Moderate interaction risks with astragalus.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Astragalus may be worth considering if you're interested in immune or metabolic support, but it's not proven for any specific condition yet. If you take lithium, diabetes medications, immunosuppressants, or cyclophosphamide, or if you're pregnant or nursing, check with your doctor or pharmacist before starting.

The interaction data is theoretical rather than proven in humans, but the risks are real enough to warrant a conversation with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astragalus Root Extract 300 mg, straight from the product label.

Brand Vital Nutrients
Barcode (UPC) 693465201114
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 304943
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astragalus Root Extract 300 mg by Vital Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
693465201114
IngredientAmount% DV
Astragalus Root Extract, Powder600 mg--

Other ingredients: Cellulose, Calcium Carbonate, Rice, Powder, Silica, Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store sealed in a cool dry place

Precautions

Keep out of reach of children

Use only if safety seal is intact

Warning: If pregnant, consult your physician before taking.

Suggested/Recommended/Usage/Directions

Recommendations: Take 2 capsules twice daily or as directed by your healthcare professional.

Formulation

Excludes coatings, binders, gluten (wheat, rye, barley), milk/dairy (casein, whey), soy protein, egg protein, sugar. Verified by independent testing

Raw materials and finished products are independently tested by U.S. labs. Learn more at vitalnutrients.net

FDA Statement of Identity

Dietary Supplement

See for yourself

Astragalus Root Extract 300 mg by Vital Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Astragalus Root Extract 300 mg by Vital Nutrients

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Astragalus Root Extract, Powder

Interacts with
208 drugs
600 mg per serving Form: Astragalosides

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus Root Extract, Powder monograph & interactions

Other (inactive) ingredients: Cellulose, Calcium Carbonate, Rice, Powder, Silica, Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astragalus Root Extract 300 mg by Vital Nutrients Drug Interactions

Want to check YOUR meds against Astragalus Root Extract 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Astragalus Root Extract 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astragalus Root Extract, Powder4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Astragalus Root Extract 300 mg, from the product label.

Vital Nutrients

See all Vital Nutrients products
Name
Vital Nutrients
Street Address
45 Kenneth Dooley Dr
City
Middletown
State
CT
ZipCode
06457
Web Address
vitalnutrients.net
Pharmacist Counseling Corner

Astragalus Root Extract 300 mg by Vital Nutrients: Common Questions

Does Astragalus Root Extract 300 mg by Vital Nutrients interact with any medications?
Yes. Based on its ingredients, Astragalus Root Extract 300 mg has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astragalus Root Extract 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data to know whether astragalus is safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in either situation.
What does astragalus actually do?
Research suggests astragalus may stimulate immune function and possibly lower blood sugar, but the evidence is insufficient to say for certain that it helps any specific condition. We hold no reliable evidence that it works for hay fever, asthma, anemia, angina, or other conditions.
Are there any side effects I should know about?
Astragalus is generally well tolerated short-term, but some people in clinical trials have reported dizziness. Limited human safety data is available, so if you notice any unusual symptoms, mention them to your doctor or pharmacist.
Why does this interact with so many medications?
This product has interactions documented with 208 individual medications total — not because astragalus is inherently dangerous, but because it appears to affect how your immune system and kidney function work, which touches several drug classes.
Can I take this with diabetes or blood pressure medication?
If you take diabetes drugs, astragalus could theoretically increase the risk of low blood sugar — check with your doctor first. For blood pressure or other medications, use the search tool on this page to check your specific prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Astragalus Root Extract 300 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astragalus Root Extract 300 mg label
Go deeper

The Full Monographs Behind Astragalus Root Extract 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Astragalus Root Extract 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
  10. Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
  11. Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
  12. Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
  13. Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):

See these in context on the Astragalus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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