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Dietary supplement

B-1 250 mg Ingredients & Drug Interactions

by Vitamin World

B-1 250 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B-1 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

B-1 250 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B-1 250 mg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with B-1 250 mg by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B-1 250 mg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: thiamine (also called vitamin B1), at 250 mg per tablet. Thiamine is a B vitamin your body needs to turn food into energy and keep your nerves and heart working properly.

The tablet also contains vegetable cellulose as an inactive ingredient (a filler and capsule material).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports energy metabolism and nervous system.
  • We looked for evidence on: Thiamine deficiency, Wernicke-Korsakoff syndrome (WKS), Fatigue, Beriberi, Carbohydrate metabolism.
  • The strongest evidence on file: Thiamine is rated "Effective" for Thiamine deficiency (Natural Medicines).
  • Also on file: Thiamine is rated "Effective" for Wernicke-Korsakoff syndrome (WKS).
  • Also on file: Thiamine is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome (a serious neurological condition from thiamine lack). The evidence also suggests it may help with dysmenorrhea (period pain), though that use is still considered possibly effective.

For mosquito repellent and heart failure, the evidence suggests it's probably not effective.

The evidence, ingredient by ingredient Thiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very well tolerated when taken by mouth in normal amounts. Allergic reactions and skin conditions like dermatitis are rare.

If you receive thiamine by injection (not this product), very rare hypersensitivity reactions can happen — but this oral tablet carries no such risk. Thiamine is needed in pregnancy and while breastfeeding.

The safety data rates it likely safe during both. If you're pregnant or nursing and considering a supplement dose beyond your regular diet, talk with your doctor or midwife about what's right for you.

Side effects, ingredient by ingredient Thiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take trimethoprim (Proloprim), an antibiotic, let your pharmacist know before starting this supplement — it may raise your thiamine levels. No other major interactions are documented for the ingredients we hold data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

B-1 250 mg is a straightforward thiamine supplement best suited for someone who needs to correct a deficiency or prevent one. If you take trimethoprim or any other medications, check them against the tool below first.

Otherwise, this is a low-risk choice — just confirm the dose is right for your situation with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B-1 250 mg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 074312706301
Net contents 100 Easy to Swallow Tablet(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 64806
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B-1 250 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
074312706301
IngredientAmount% DV
Thiamine250 mg16667%

Other ingredients: Vegetable Cellulose, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Vegetarian Vitamin Supplement

Formulation

Vegetarian Vitamin Supplement

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium free.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal.

General Statements

The role of Thiamin (Vitamin B-1) in energy metabolism is to help your body convert food to energy. Thiamin supports carbohydrate metabolism and also plays a role in the nervous system.

Supports energy metabolism

To reorder prod. #630 www.vitaminworld.com 1-800-228-4533

Formula

B Vitamins

Brand IP Statement(s)

2016 Vitamin World, Inc.

Nutrition from the source

At Vitamin World we ensure the quality of all of our premium nutritional products, every step of the way. Strict quality analysis at world-class facilities guarantees that all Vitamin World products are at the highest standard of potency and purity.

General

PROD. #630 B630 09F

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store at room temperature.

Seals/Symbols

Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B-1 250 mg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B-1 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B-1 250 mg by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Thiamine

Interacts with
3 drugs
250 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

B-1 250 mg by Vitamin World Drug Interactions

Want to check YOUR meds against B-1 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in B-1 250 mg interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in B-1 250 mg interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in B-1 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B-1 250 mg, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

B-1 250 mg by Vitamin World: Common Questions

Does B-1 250 mg by Vitamin World interact with any medications?
Yes. Based on its ingredients, B-1 250 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B-1 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
Yes — thiamine is needed in both pregnancy and breastfeeding and is rated likely safe. However, use only the dose your doctor or midwife recommends for you, rather than deciding on your own.
Can I take this if I'm on antibiotics?
Most antibiotics are fine. If you take trimethoprim (Proloprim), check with your pharmacist first — it may change how much thiamine your body absorbs. For other antibiotics, the checker below can confirm.
What's thiamine actually for?
Thiamine, or B1, helps your body convert food into energy and keeps your nerves and heart working properly. It's mainly used to prevent or treat thiamine deficiency and a serious neurological condition called Wernicke-Korsakoff syndrome.
Will this help with period pain?
The evidence suggests thiamine may help with dysmenorrhea (period pain), but that use is still considered possibly effective — it's not as proven as its use for thiamine deficiency.
Are there any fillers or other stuff in here?
The active ingredient is thiamine. The tablet also contains vegetable cellulose as a filler and binder — that's it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B-1 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B-1 250 mg label
Go deeper

The Full Monographs Behind B-1 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph →
Sources

Sources & How We Checked

B-1 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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