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Dietary supplement

Benfotiamine 80 mg Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Premium

Benfotiamine 80 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Benfotiamine 80 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Benfotiamine 80 mg is a dietary supplement by AOR Advanced Orthomolecular Research Premium with 1 active ingredient. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium

Ask about any prescription or over-the-counter medication and we check it for interactions with Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: thiamine (vitamin B1) at 80 mg per capsule, delivered as benfotiamine, a fat-soluble form designed for better absorption. Thiamine is an essential B vitamin your body needs for energy production and nerve function.

The capsule also contains inactive ingredients — microcrystalline cellulose, hypromellose, purified water, and sodium stearyl fumarate — which are standard binders and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Thiamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Thiamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Thiamine deficiency — rated "Effective" (Natural Medicines).
  • On file: Wernicke-Korsakoff syndrome (WKS) — rated "Effective" (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Natural Medicines).

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome (a serious brain condition caused by severe thiamine lack). The evidence also suggests it may help with menstrual cramps (dysmenorrhea), though the data is less robust.

For mosquito repellent and heart failure, the available evidence suggests it's unlikely to be effective.

The evidence, ingredient by ingredient Thiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe when taken by mouth in normal amounts. Allergic reactions are rare but possible — you might occasionally see dermatitis or other skin reactions.

Thiamine is essential during pregnancy and breastfeeding, so the safety data supports its use; if you're pregnant or nursing and considering a supplement, talk with your doctor or pharmacist about the right dose for you.

Side effects, ingredient by ingredient Thiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take trimethoprim (Proloprim) or any other prescription medication, check your exact drugs with the search tool on this page before you start. The interaction we know about is Minor in severity, but your doctor or pharmacist should confirm this product is right for your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Benfotiamine is a solid choice if you need to correct a thiamine deficiency or treat Wernicke-Korsakoff syndrome. If you take trimethoprim (an antibiotic) or any other medications, check with your doctor or pharmacist before starting — this product can affect how one antibiotic works in your body.

Otherwise, it's well tolerated in normal doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Benfotiamine 80 mg, straight from the product label.

Brand AOR Advanced Orthomolecular Research Premium
Barcode (UPC) 624917080513
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 263452
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
624917080513
IngredientAmount% DV
Thiamine320 mg, 80 mg26667%, 6667%

Other ingredients: Microcrystalline Cellulose, Hypromellose, Water, Purified, Sodium Stearyl Fumarate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Product of Canada

Precautions

Do not use if safety seal is broken.

Warning: Do not use if you are pregnant or breastfeeding. Consult your physician if you have a medical condition, or are taking any medication.

Persons with thiamin hypersensitivity should not take this product.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place.

Formula

Discussion: Benfotiamine is a naturally-occurring form of thiamin (vitamin B1). Benfotiamine's superior ability to penetrate cell membranes increases its bioavailability over conventional thiamin supplements. This allows for the use of benfotiamine to promote all of the benefits of vitamin B1.

Highly bioavailable vitamin B1

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule 1-4 times a day with food, or as directed by a health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Benfotiamine 80 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Thiamine

Interacts with
3 drugs
320 mg per serving Form: Benfotiamine, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Water, Purified, Sodium Stearyl Fumarate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium Drug Interactions

Want to check YOUR meds against Benfotiamine 80 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in Benfotiamine 80 mg interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Benfotiamine 80 mg interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Benfotiamine 80 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Benfotiamine 80 mg, from the product label.

AOR Advanced Orthomolecular Research Premium

See all AOR Advanced Orthomolecular Research Premium products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium: Common Questions

Does Benfotiamine 80 mg by AOR Advanced Orthomolecular Research Premium interact with any medications?
Yes. Based on its ingredients, Benfotiamine 80 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Benfotiamine 80 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is benfotiamine better absorbed than regular thiamine?
Benfotiamine is a fat-soluble form of thiamine designed for better absorption, which is why it's used in this product. The product facts don't specify absorption comparisons, but the benfotiamine form is marketed for that advantage — talk with your pharmacist if you have questions about which form is right for your needs.
Can I take this if I'm pregnant?
Thiamine is needed during pregnancy, and the safety data rates it as likely safe. If you're pregnant and considering a supplement, talk with your doctor or pharmacist about the right dose for you — they'll personalize the advice for your situation.
Can I take this while breastfeeding?
Thiamine is essential while breastfeeding, and the safety data supports its use. Use supplements at the recommended amounts and check in with your doctor or pharmacist to make sure the dose is right for you and your baby.
Will this help with my menstrual cramps?
The evidence suggests thiamine may help with menstrual cramps (dysmenorrhea), though the data isn't as strong as it is for deficiency. If you're considering it for that reason, discuss it with your doctor or pharmacist — they can help you figure out if it makes sense for you.
What's the difference between benfotiamine and regular thiamine?
Benfotiamine is a fat-soluble form of thiamine, which means it's absorbed differently — especially through fatty tissues. Regular thiamine is water-soluble. The benfotiamine form in this product is designed for better absorption, which is why manufacturers choose it.
Are there any side effects?
Thiamine is very safe when taken by mouth in normal amounts. Allergic reactions like dermatitis are rare. If you have a history of allergies or skin reactions, mention it to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Benfotiamine 80 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Benfotiamine 80 mg label
Go deeper

The Full Monographs Behind Benfotiamine 80 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph →
Sources

Sources & How We Checked

Benfotiamine 80 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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