Benfotiamine Ingredients & Drug Interactions
by XYMOGEN
What is this page for?
First and foremost: checking Benfotiamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Benfotiamine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), supporting healthy nerve function, thiamine deficiency.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Benfotiamine by XYMOGEN
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: benfotiamine, a form of thiamine (vitamin B1) designed to absorb more easily into fatty tissues than standard thiamine. The capsule also includes inactive ingredients — microcrystalline cellulose, HPMC, dicalcium phosphate, stearic acid, magnesium stearate, and silica — which serve as fillers and binders.
Does it work?
Moderate evidence
Benfotiamine is possibly effective for diabetic neuropathy (nerve damage from high blood sugar). For diabetic nephropathy (kidney damage from diabetes), the evidence suggests it is possibly ineffective.
The evidence isn't established in our data for alcohol use disorder, Alzheimer disease, or general peripheral neuropathy — we simply don't have enough reliable studies to rate it one way or the other.
How safe is it?
Well-documented data
Benfotiamine is generally well tolerated in the studies we have, but long-term safety hasn't been fully worked out yet. In one trial of 98 people taking 300–600 mg daily for 6 weeks, a small number reported allergic skin reactions or mild stomach discomfort — and these rates didn't differ from placebo.
There isn't enough safety information for pregnancy, so the data advises avoiding it unless your doctor specifically recommends it. Safety while breastfeeding has not been well studied, so caution is advised — talk it over with your doctor or pharmacist for personalized guidance.
Meds to double-check
No known interactions
No interactions are documented in our data for benfotiamine. Still, run your exact medications through the search tool below or confirm with your doctor or pharmacist before you begin.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Benfotiamine may be worth considering if you have diabetic nerve damage and want to explore a vitamin B1 form that absorbs into fatty tissues. Because long-term safety data is limited and pregnancy safety hasn't been well studied, check with your own doctor or pharmacist before you start — especially if you're pregnant, breastfeeding, or taking other medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Benfotiamine, straight from the product label.
| Brand | XYMOGEN |
|---|---|
| Net contents | 30 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2012 |
| DSLD ID | 5945 |
| Product type | Vitamin |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Benfotiamine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Benfotiamine | 300 mg | -- |
Other ingredients: Microcrystalline Cellulose, HPMC, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
DIRECTIONS: Take two capsules in the morning and two capsules in the evening, or as directed by your healthcare practitioner.
Precautions
Keep out of reach of children.
• Pharmaceutical Grade • Professional Use Only
Avoid if allergic to any ingredient.
CAUTIONS: Consult your healthcare practitioner before use.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
STORAGE: Keep tightly closed in a cool, dry place.
General Statements
Benfotiamine is a liquid-soluble derivative of thiamin that demonstrates improved absorption and duration of activity compared to water-soluble thiamin. Benfotiamine activates transketolase activity, thereby facilitating conversion of harmful glucose metabolites and positively affecting AGE formation. It supports peripheral nerve health and may support vascular health, including the microvasculature of the retina and kidney. Benfotiamine is also an excellent way to improve thiamin status.*
Lipid-Soluble, Highly Bioavailable Thiamin Derivative*
This package is completely recyclable (recycle)
EXCLUSIVE PROFESSIONAL FORMULAS
General
TC# E3570301 REV. 111511
Brand IP Statement(s)
XYMOGEN 2011
All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.
Formulation
DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, soy, animal or dairy products, artificial colors, artificial sweeteners, or preservatives.
Seals/Symbols
VEGETABLE CAPSULES
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Benfotiamine by XYMOGEN label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Benfotiamine by XYMOGEN
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Benfotiamine
No knowninteractions
Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...
Benfotiamine monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, HPMC, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Benfotiamine by XYMOGEN Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Benfotiamine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Benfotiamine, from the product label.
XYMOGEN
See all XYMOGEN products- Name
- XYMOGEN Exclusive Professional Formulas
- Street Address
- 725 S. Kirkman Rd.
- City
- Orlando
- State
- FL
- ZipCode
- 32811
- Phone Number
- 800-647-6100
- Web Address
- www.xymogen.com
Benfotiamine by XYMOGEN: Common Questions
Does Benfotiamine by XYMOGEN interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is benfotiamine, and how is it different from regular B1?
Can I take this if I'm pregnant?
What side effects might I experience?
Does benfotiamine work for diabetic kidney damage?
How long can I safely take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Benfotiamine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Benfotiamine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Benfotiamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 1 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Benfotiamine 1 reference
- Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC