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Dietary supplement

Bilberry 1000 mg Plus Lutein Ingredients & Drug Interactions

by Spring Valley

Bilberry 1000 mg Plus Lutein label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry 1000 mg Plus Lutein against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry 1000 mg Plus Lutein is a dietary supplement by Spring Valley with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry 1000 mg Plus Lutein by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry 1000 mg Plus Lutein by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry 1000 mg Plus Lutein by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains two active ingredients: bilberry (a dark berry extract) and lutein (a yellow plant pigment). Bilberry has long been used traditionally to support eye health, though its effectiveness for most conditions isn't well established.

Lutein is concentrated in the retina of the eye and is being studied for age-related vision changes.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Complete eyesight support with vision nutrients.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Bilberry is rated "Possibly Ineffective" for Night vision.

For lutein, the evidence shows it's possibly effective for slowing age-related macular degeneration (AMD) and cataracts, two common eye conditions that worsen with age. For bilberry, the data we hold is thinner — the evidence for night vision is actually rated as possibly ineffective, and for other uses (cognitive decline, AMD, and heart health markers) the evidence simply isn't strong enough to rate.

Don't expect dramatic results with either ingredient based on what's currently known.

The evidence, ingredient by ingredient Lutein Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both lutein and bilberry are generally well tolerated when taken by mouth at typical doses. Bilberry may cause dark-colored stools, flatulence, or mild stomach discomfort — a small number of trial participants reported these effects.

Lutein at doses up to 20 mg daily hasn't caused adverse effects in trials. Lutein is rated Likely Safe in pregnancy and lactation, and bilberry is too, though long-term safety data for bilberry supplements is limited.

If you're pregnant, nursing, or have concerns, run it past your doctor or pharmacist for advice tailored to your situation.

Side effects, ingredient by ingredient Lutein Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on blood thinners or antiplatelet drugs like warfarin or aspirin — bilberry may increase bleeding risk (Moderate severity). Also flag any diabetes medications, since bilberry may lower blood sugar.

If you take erlotinib (Tarceva) or drugs metabolized by the liver enzyme CYP2E1, mention those too. Your pharmacist can help you sort through the details.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product might be worth considering if you're interested in supporting eye health, especially if you're concerned about age-related changes like cataracts or macular degeneration — the evidence for lutein is more solid than for bilberry. If you take blood thinners, diabetes medications, or cancer drugs like erlotinib, you'll need to check with your doctor or pharmacist before adding it.

Talk it over with your own healthcare provider to see if it fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry 1000 mg Plus Lutein, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131111153
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 13035
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry 1000 mg Plus Lutein by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
681131111153
IngredientAmount% DV
Lutein5 mcg--
Bilberry1000 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin, Caramel color, yellow Beeswax, Corn Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Spring Valley - Bilberry Plus Lutein 1000 mg, Concentrated Extract, 60 Softgels

General Statements

Advantages: - Complete eyesight support formula with top 6 vision supporting nutrients. - Addition of Lutein adds superior eye support. - Powerful antioxidant helps protect cells. - Rapid release softgels. Bilberry Plus Lutein nutritionally supports healthy visual function. Bilberry fruit naturally contains a unique class of bioflavonoids called anthocyanosides. Lutein is a carotenoid found in leafy green vegetables, such as spinach, and promotes healthy visual function.

Potency: 1000 mg Quantity: 60 Softgels Brand: Spring Valley Item# (UPC): 681131111153 Condition: Brand New & Factory Sealed. Expiration Date: 1 year or more. Should you wish to know the expiration date for a particular product, please feel free to send us an email.

Made in the USA.

EYE HEALTH

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel up to four times daily, preferably with a meal.

Storage

Store in a cool, dry place with lid tightly closed.

Precautions

For your protection, do not use if imprinted seal under cap is broken or missing.

If you are pregnant or nursing a baby, ask a doctor before using this product.

Warnings: Keep out of reach of children.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry 1000 mg Plus Lutein by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry 1000 mg Plus Lutein label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry 1000 mg Plus Lutein by Spring Valley

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
5 mcg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Bilberry

Interacts with
275 drugs
1000 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin, Caramel color, Yellow Beeswax, Corn Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry 1000 mg Plus Lutein by Spring Valley Drug Interactions

Want to check YOUR meds against Bilberry 1000 mg Plus Lutein?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry 275

Individual Drug Interactions

The ingredients in Bilberry 1000 mg Plus Lutein interact with 275 drugs. Click any drug to see the details.

1 of the 2 ingredients in Bilberry 1000 mg Plus Lutein interact with drugs. Each result below shows which ingredient is responsible. Bilberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry 1000 mg Plus Lutein with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry 1000 mg Plus Lutein, from the product label.

Spring Valley

See all Spring Valley products
Name
US Nutrition, Inc.
City
Bohemia
State
NY
ZipCode
11716-2510
Pharmacist Counseling Corner

Bilberry 1000 mg Plus Lutein by Spring Valley: Common Questions

Does Bilberry 1000 mg Plus Lutein by Spring Valley interact with any medications?
Yes. Based on its ingredients, Bilberry 1000 mg Plus Lutein has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry 1000 mg Plus Lutein contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lutein actually help with vision problems?
Lutein is possibly effective for slowing age-related macular degeneration and cataracts — two real concerns as you age. But the evidence is in the "possibly" range, not proven. For other eye conditions, the evidence either doesn't exist or points the other way.
What about bilberry — does it really improve night vision?
The evidence actually suggests it's not effective for night vision. Bilberry extract hasn't been well studied for most other uses either, so we can't say much about what it does for you.
Will this turn my stool or tongue dark?
It might. In studies, some people taking bilberry developed dark-colored stools and even dark discoloration of the tongue. In one study, about half the participants reported dark green stools after four weeks. It's harmless but can be startling.
Is it safe if I'm breastfeeding?
Bilberry is rated Likely Safe in pregnancy and lactation. Lutein is also Likely Safe, though the safety data for higher supplement doses while nursing is more limited than for food amounts. If you want to be extra cautious, check with your doctor or pharmacist about dosing.
Can I take this long-term?
Bilberry supplement safety for the long haul hasn't been well studied, so the caution here is real. Lutein at typical doses is considered safe, but with bilberry you're working with limited information. Your doctor or pharmacist can help you weigh whether it's right for ongoing use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry 1000 mg Plus Lutein is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry 1000 mg Plus Lutein label
Go deeper

The Full Monographs Behind Bilberry 1000 mg Plus Lutein’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry 1000 mg Plus Lutein's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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