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Dietary supplement

Bilberry Extract 150 mg Ingredients & Drug Interactions

by Spring Valley

Bilberry Extract 150 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry Extract 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry Extract 150 mg is a dietary supplement by Spring Valley with 3 active ingredients. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Bilberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry Extract 150 mg by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Extract 150 mg by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry Extract 150 mg by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: organic bilberry extract, organic blueberry extract, and organic lutein. Bilberry and blueberry are both berry sources rich in anthocyanidins—plant pigments traditionally used for eye health.

Lutein is a yellow pigment (carotenoid) that concentrates in the retina and may support vision as you age. The capsules also contain two inactive ingredients: hypromellose (a plant-based capsule material) and organic rice hull concentrate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health with bilberry, lutein and blueberry.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence for bilberry and blueberry extracts is thin. For night vision—what many people buy bilberry for—the data shows it's likely ineffective.

For other uses like age-related cognitive decline, macular degeneration, cholesterol, and vein health, we don't have enough reliable evidence to rate them either way. Lutein performs better: it's possibly effective for age-related macular degeneration and cataracts.

Overall, if vision support is your goal, lutein may offer more backing than the berry extracts alone.

The evidence, ingredient by ingredient Bilberry Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry and blueberry extracts are generally well tolerated. The most common side effects are dark-colored stools (which can look alarming but is harmless—the pigments in the berries stain your digestive tract), flatulence, and mild stomach discomfort.

A small number of trial participants reported temporary digestive upset, and in one study, dark discoloration of the tongue and teeth was noted. Lutein at typical doses is also well tolerated with no adverse effects documented.

That said, concentrated supplement doses of bilberry and blueberry lack long-term safety data, so the caution is to use them cautiously and talk with your doctor if you have concerns. Both ingredients are likely safe in pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Bilberry Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs, blood sugar medications, liver enzyme CYP2E1 substrates, or the cancer drug erlotinib (Tarceva). Bilberry and blueberry extracts carry Moderate-severity risks with all four of these medication types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula might appeal to someone looking for comprehensive eye support, since it pairs lutein (which has some evidence for age-related eye conditions) with bilberry and blueberry extracts. However, if you're on blood thinners, diabetes medications, or erlotinib, you need to check with your doctor or pharmacist first—the berry extracts carry real interaction risks.

Be aware of the side effects (dark stools, gas) and accept that bilberry evidence for better night vision is weak. Talk it over with your healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry Extract 150 mg, straight from the product label.

Brand Spring Valley
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 239847
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Halal, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry Extract 150 mg by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
organic Bilberry extract150 mg--
organic Blueberry extract100 mg--
organic Lutein6 mg--

Other ingredients: Hypromellose, organic Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Bilberry Extract 150 mg per capsule Made with 150 mg Organic Bilberry Extract, 100 mg Organic Blueberry Extract, and 6 mg Organic Lutein Eye Health with Bilberry, Lutein and Blueberry

Halal

OU (Kosher)

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Non GMO Project Verified Nongmoproject.org Halal OU (Kosher)

Quality Assurance International Certified Organic

Formulation

Certified Organic by QAI

Product of China

Non GMO Project Verified Nongmoproject.org No gluten, yeast, wheat, milk, or milk derivatives, lactose, sugar, soy, artificial color, artificial flavor

Sodium (less than 5 mg per serving)

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take one capsule daily, preferably with a meal.

Precautions

Warning: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their doctor before using this product.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

For your protection, do not use if printed seal under cap is broken or missing.

Storage

Store at room temperature 59 degrees - 86 degrees F (15 degrees - 30 degrees C). Keep bottle tightly closed.

General Statements

Quality Guaranteed For questions or comments call 1-866-251-1662. Walmart.com/springvalley

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry Extract 150 mg by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry Extract 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry Extract 150 mg by Spring Valley

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Bilberry extract

Interacts with
275 drugs
150 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Organic Bilberry extract monograph & interactions

Organic Blueberry extract

Interacts with
275 drugs
100 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Organic Blueberry extract monograph & interactions

Organic Lutein

No known
interactions
6 mg per serving Form: Marigold extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Organic Lutein monograph & interactions

Other (inactive) ingredients: Hypromellose, Organic Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry Extract 150 mg by Spring Valley Drug Interactions

Want to check YOUR meds against Bilberry Extract 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

organic Bilberry extract 275

Individual Drug Interactions

The ingredients in Bilberry Extract 150 mg interact with 275 drugs. Click any drug to see the details.

1 of the 3 ingredients in Bilberry Extract 150 mg interact with drugs. Each result below shows which ingredient is responsible. organic Bilberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry Extract 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Bilberry extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
organic Bilberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry Extract 150 mg, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-866-251-1662
Web Address
Walmart.com/springvalley
Pharmacist Counseling Corner

Bilberry Extract 150 mg by Spring Valley: Common Questions

Does Bilberry Extract 150 mg by Spring Valley interact with any medications?
Yes. Based on its ingredients, Bilberry Extract 150 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry Extract 150 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this really help my night vision?
Probably not. The data shows bilberry extract is likely ineffective for night vision—that's the main use people buy it for. Lutein in the formula has better evidence for age-related macular degeneration and cataracts, but not for low-light vision.
What's the difference between bilberry and blueberry in here?
Both are berry sources with similar active compounds (anthocyanidins). This product uses both, so you're getting two versions of roughly the same plant chemistry. The research applies to bilberry more directly, but blueberry carries the same interaction and safety profile.
Is it safe to take while pregnant or breastfeeding?
Both bilberry and blueberry extracts, and lutein, are rated likely safe in pregnancy and while breastfeeding. Lutein is naturally in breast milk anyway. That said, supplement safety in these situations isn't heavily studied, so talk with your doctor or midwife first.
Why are my stools dark or black after taking this?
That's the anthocyanin pigments from the bilberry and blueberry staining your digestive tract as they pass through. It's harmless and temporary—just a visual side effect. You might also notice some discoloration of your tongue.
Can I take this with my other supplements?
The facts only cover interactions with medications, not other supplements. If you're stacking multiple products, mention all of them to your pharmacist so they can spot any overlaps or conflicts.
How much lutein is in each capsule?
The product facts don't break down individual ingredient doses—only the total bilberry extract amount (150 mg). Ask the manufacturer or retailer for the lutein content per capsule if you need that detail.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry Extract 150 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry Extract 150 mg label
Go deeper

The Full Monographs Behind Bilberry Extract 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Bilberry Extract 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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