Bilberry Fruit Extract 1000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bilberry Fruit Extract 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bilberry Fruit Extract 1000 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bilberry Fruit Extract 1000 mg by Puritan's Pride
Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Fruit Extract 1000 mg by Puritan's Pride — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bilberry Fruit Extract 1000 mg by Puritan's Pride
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bilberry fruit extract at 1,000 mg per softgel. Bilberry is a berry rich in a group of plant compounds called anthocyanidins, which are responsible for its dark color and its reputed health effects.
The softgel capsule also contains inactive ingredients — soybean oil, gelatin, glycerin, soy lecithin, natural caramel color, and yellow beeswax — that serve as the delivery vehicle and help keep the formula stable.
Does it work?
Leans against
The evidence for bilberry's benefits is mixed and incomplete. For night vision, the research shows it's likely ineffective — you won't see better in the dark or recover from bright light faster by taking it.
For age-related cognitive decline, age-related macular degeneration (AMD), atherosclerosis, high cholesterol, and chronic venous insufficiency (poor circulation in the legs), the data we hold shows insufficient reliable evidence to say whether it works. If you're considering bilberry for any of these uses, chat with your doctor about what the current science actually supports.
How safe is it?
Well-documented data
Bilberry fruit and its extracts are generally well tolerated when taken by mouth. The most common side effects are dark-colored stools (which can range from dark green to black), flatulence, and mild stomach discomfort.
A small number of trial participants reported these effects, and one study noted mild discoloration of the tongue and even slight tooth discoloration, though this is rare. That said, the long-term safety of bilberry supplements isn't well studied.
While eating bilberries as food is fine, the safety data for concentrated supplement doses is limited. The safety notes advise caution with supplement-strength doses.
If you're pregnant or breastfeeding, the limited data suggests bilberry is likely safe — but confirm with your doctor or pharmacist for your individual situation.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — bilberry may increase bleeding risk. Also flag any diabetes medications, as bilberry could lower your blood sugar further.
If you take erlotinib (Tarceva) or any other drug processed by your liver's CYP2E1 pathway, confirm it's okay to add bilberry to your regimen.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bilberry extract might appeal to you if you're looking for an antioxidant supplement, though the proven benefits are limited. You should be extra careful if you take blood thinners, diabetes medications, or erlotinib, or if your liver processes drugs through the CYP2E1 pathway.
Talk with your doctor or pharmacist before starting it, especially if you're on any prescription medication.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bilberry Fruit Extract 1000 mg, straight from the product label.
| Brand | Puritan's Pride |
|---|---|
| Barcode (UPC) | 074312114298 |
| Net contents | 180 Rapid Release Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 287278 |
| Product type | Botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bilberry Fruit Extract 1000 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bilberry Fruit Extract | 250 mg | -- |
Other ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin, natural Caramel color, yellow Beeswax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.
To reorder Item # 1429 www.puritan.com 1-800-645-1030
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
Contains soy ingredients. Contains bioengineered food ingredients.
Storage
Store at room temperature.
Formula
A close relative of blueberries, bilberry has been widely known to herbalists since the 16th century. Our specialized formula provides bilberry in a concentrated form.
Bilberry Fruit Extract 1000 mg Traditional herb Concentrated extract
Brand IP Statement(s)
Copyright 2020 Puritan's Pride, Inc.
Seals/Symbols
QA Quality Assured
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) softgel once or twice daily, preferably with meals.
Formulation
No artificial flavor or sweetener, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bilberry Fruit Extract 1000 mg by Puritan's Pride label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bilberry Fruit Extract 1000 mg by Puritan's Pride
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.
Bilberry Fruit Extract
Interacts with275 drugs
Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...
Bilberry Fruit Extract monograph & interactionsOther (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin, Natural Caramel color, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.
Bilberry Fruit Extract 1000 mg by Puritan's Pride Drug Interactions
HelloPharmacist Interaction Report
Bilberry Fruit Extract 1000 mg by Puritan's Pride does interact with a number of medications.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin, aspirin, and clopidogrel). Bilberry extract can slow down clotting by preventing platelets from clumping together, which raises the risk of bleeding when combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to be careful if you take diabetes medications. Bilberry may lower your blood sugar, and animal research hints it could add to the blood-sugar-lowering effect of your diabetes drug — potentially pushing your glucose too low.
Additionally, bilberry extract may speed up how your body breaks down certain drugs processed through a specific liver pathway (CYP2E1), which could make those medications less effective. Finally, if you're taking erlotinib (Tarceva) for cancer, bilberry may reduce how well that drug works — though this hasn't been confirmed in human studies.
Altogether, these interactions span 275 individual medications. Before you start bilberry, run your exact medications through the checker on this page or talk with your pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bilberry Fruit Extract 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bilberry Fruit Extract 1000 mg interact with 275 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bilberry Fruit Extract 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry Fruit Extract
AbciximabReoPro
How Abciximab interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Fruit Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bilberry Fruit Extract 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bilberry Fruit Extract 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bilberry Fruit Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Bilberry Fruit Extract 1000 mg, from the product label.
Puritan's Pride
See all Puritan's Pride products- Name
- Puritan's Pride, Inc.
- City
- Ronkonkoma
- State
- NY
- ZipCode
- 11779
- Phone Number
- 1-800-645-1030
- Web Address
- www.puritan.com
Bilberry Fruit Extract 1000 mg by Puritan's Pride: Common Questions
Does Bilberry Fruit Extract 1000 mg by Puritan's Pride interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will bilberry really help my night vision?
What are the most common side effects?
Is it safe to take while pregnant or breastfeeding?
How much do we actually know about long-term safety?
Does bilberry work for age-related macular degeneration or cognitive decline?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bilberry Fruit Extract 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bilberry Fruit Extract 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bilberry Fruit Extract 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bilberry 14 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
- Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
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