Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

BioSil Ingredients & Drug Interactions

by Natural Factors

BioSil label
See full label image
Capsule Category: Single Vitamin And Mineral
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BioSil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

BioSil is a dietary supplement by Natural Factors with 2 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BioSil by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with BioSil by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BioSil by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BioSil contains 2 active ingredients: silicon and choline. Silicon is included for its possible role in bone health, particularly for osteoporosis; the evidence is still evolving.

Choline is an essential nutrient your body uses for multiple functions, though its specific roles in the conditions this product targets aren't yet well established in research. The capsule also contains silicon dioxide, purified water, and a capsule shell as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: skin, hair, nails, bones and joints.
  • We looked for evidence on: Aging skin, Androgenic alopecia, Osteoporosis, Joint health, Connective tissue strength, Hair loss.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Silicon is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Androgenic alopecia.

The evidence for silicon in osteoporosis is possibly effective—meaning the science suggests a benefit, but more research would strengthen that claim. For hair loss (androgenic alopecia) and gum and implant health (dental peri-implantitis), there isn't enough reliable evidence yet to say whether silicon helps or doesn't.

Choline in this product is rated possibly ineffective for athletic performance and has insufficient evidence for the other conditions listed on the label, so we don't know yet whether it'll help with those.

The evidence, ingredient by ingredient Silicon Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Silicon from food and water is generally well tolerated, but long-term safety at high supplement doses hasn't been thoroughly studied, so caution is warranted if you're using this long-term. Choline is generally safe in food amounts, though high-dose supplements can cause side effects—the daily upper limit is 3.5 grams.

At very high doses (9 grams or more daily), choline can cause nausea, vomiting, diarrhea, and a fishy body odor. Both ingredients are rated likely safe in pregnancy and lactation, though choline's needs are higher while breastfeeding and should be managed under professional guidance.

Side effects, ingredient by ingredient Silicon Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take BioSil, double-check with your doctor or pharmacist if you're on atropine or any anticholinergic medications. Choline may reduce how these drugs work.

If you take any other prescription or over-the-counter medications, use the interaction checker below to verify there are no other concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

BioSil might be worth considering if you're interested in bone health support, though the evidence is still developing. If you take atropine or any other prescription medications, check with your pharmacist or doctor before starting—choline can interact with certain drugs.

Keep in mind that high doses of choline can cause digestive upset and fishy body odor, so stick to the label dose. A conversation with your doctor or pharmacist about whether this fits your health goals is always a smart move.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BioSil, straight from the product label.

Brand Natural Factors
Net contents 60 Small Vegan Liquid Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220185
Product type Single Vitamin And Mineral
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BioSil by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Silicon5 mg--
Choline100 mg18%

Other ingredients: Silicon Dioxide, purified Water, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule, two times daily.

Clinical Facts Choline-Stabilized Orthosilicic Acid (ch-OSA) Clinically Proven Dosage ch-OSA clinically proven 1 capsule, 2 times daily

Precautions

Consult your healthcare professional prior to use if you have, or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Keep out of the reach of children.

Formulation

Vegan

This product does not contain soy, dairy, egg, corn, wheat, gluten, fish/shellfish, nuts/tree nuts.

Generate your own collagen naturally Beautiful skin, hair and nails Healthy bones and joints

Reduces fine lines & wrinkles Increases skin elasticity Thickens & strengthens hair Strengthens nails Promotes healthy bones & joints Increases collagen formation Helps protect existing collagen

Advanced Collagen Generator After age 21, collagen levels decline by 1.0-1.5% every year. BioSil is clinically proven to increase collagen formation. Best of all, BioSil works through your body natural collagen-generating pathways. That's why all the collagen you gain with BioSil has your own DNA fingerprint. You have our assurance that it is never promoted through foreign animal sources.

Ethically produced BioSil is created by leading collagen researchers and maintains the highest ethical standards, from formulation to manufacturing.

No artificial colors or flavors Non-GMO

Sustainably sourced Manufactured in solar powered facility MWU (minimal water use) compliant

No animal parts or sea organisms

Increase your 3 beauty proteins The condition of your hair, skin, and nails depends on 3 proteins, known as your "3 beauty proteins." BioSil increases all three. Collagen: reduces fine lines and wrinkles Elastin: tightens skin and gives it "bounce back". Keratin: increases hair thickness and strength, increases nail strength.

Brand IP Statement(s)

ch-OSA, BioSil, the ch-OSA logo and Advanced Collagen Generator are registered trademarks of Bio Minerals NV.

2019 Bio Minerals NV

U.S. Patents 7,968,528 and other patents pending.

FDA Disclaimer Statement

These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

ch-OSA Original formula

FDA Statement of Identity

Dietary Supplement

Storage

Store at 59-86 degrees F (15-30 degrees C). Protect from light and moisture.

General Statements

Clinically proven results BioSil has been clinically proven in double-blind, placebo-controlled clinical trials. Results are published in prestigious, peer-reviewed medical journals, all with a high citation index.

New

ch-OSA has been tested in rigorous double-blind placebo controlled clinical trials for both efficacy and safety. The results are published in peer reviewed medical journals (see insert for details). Made in Belgium

Seals/Symbols

isura Non-GMO - Mass Spec Documentation Lab tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BioSil by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BioSil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BioSil by Natural Factors

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Silicon

No known
interactions
5 mg per serving Form: Choline-stabilized Orthosilicic Acid

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silicon monograph & interactions

Choline

Interacts with
16 drugs
100 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Purified Water, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

BioSil by Natural Factors Drug Interactions

Want to check YOUR meds against BioSil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in BioSil interact with 16 drugs. Click any drug to see the details.

1 of the 2 ingredients in BioSil interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in BioSil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BioSil, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors
Street Address
14224 167th Street SE
City
Monroe
State
WA
ZipCode
98272
Pharmacist Counseling Corner

BioSil by Natural Factors: Common Questions

Does BioSil by Natural Factors interact with any medications?
Yes. Based on its ingredients, BioSil has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BioSil contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take BioSil while pregnant or breastfeeding?
Both silicon and choline are rated likely safe in pregnancy and lactation. That said, choline needs are higher while breastfeeding, so use supplements only under your doctor's or pharmacist's guidance to make sure you're getting the right amount for you and your baby.
Will BioSil actually help my thinning hair or strengthen my nails?
Silicon is included for those reasons, but the evidence isn't established yet—there's just not enough reliable research to say whether it works. If hair or nail health is your main goal, talk with your doctor about what the science supports right now.
What are the side effects of BioSil?
Silicon at supplement levels is generally well tolerated. Choline can cause a fishy body odor, especially at doses above 3.5 grams daily. At very high doses (9 grams daily or more), it may cause nausea, vomiting, diarrhea, or sweating. Stick to the label dose to keep side effects minimal.
Is it safe to take BioSil long-term?
Long-term safety of high-dose silicon supplements isn't well studied, so use caution if you plan to take it for years. Choline is generally safe long-term when used at normal doses, though very high doses aren't recommended. Your doctor can advise on how long is right for you.
Can I take BioSil if I'm on blood pressure or heart medications?
We don't have documented interactions between BioSil's ingredients and those drug classes. That said, always check your full medication list with the interaction tool on this page or ask your pharmacist to be sure—every situation is different.
What exactly is silicon, and why is it in this supplement?
Silicon is a mineral found naturally in foods and water. It's included in BioSil because early research suggests it may support bone health, particularly for osteoporosis, though more evidence is still needed. It may also be promoted for hair and skin, but the science there is less established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BioSil is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BioSil label
Go deeper

The Full Monographs Behind BioSil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

BioSil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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