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Dietary supplement

BioSil Ingredients & Drug Interactions

by Natural Factors

BioSil label
See full label image
Powder Category: Single Vitamin And Mineral
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BioSil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

BioSil is a dietary supplement by Natural Factors with 2 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BioSil by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with BioSil by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BioSil by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BioSil is a 2-ingredient powder. It contains silicon, a mineral found naturally in foods and water, and choline, an essential nutrient your body needs for cell function and liver health.

The other ingredients are inactive — sugar, modified starch, ascorbic acid (vitamin C), orange flavor, sodium chloride (salt), calcium phosphate, and stevia — they're mostly for taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Collagen generation, skin, hair, nails, bones, joints.
  • We looked for evidence on: Aging skin, Androgenic alopecia, Osteoporosis, Joint health, Connective tissue support.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Silicon is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Androgenic alopecia.

Silicon is possibly effective for osteoporosis (weak bones). For other uses — hair loss and gum health around dental implants — the evidence isn't established well enough to rate.

Choline has insufficient evidence to establish it works for athletic performance, bronchitis, age-related thinking decline, liver issues related to special nutrition, hay fever, or Alzheimer's disease. The evidence we hold doesn't show it's effective for those purposes.

The evidence, ingredient by ingredient Silicon Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Silicon taken by mouth in food and supplement amounts is generally well tolerated. High-dose or long-term safety hasn't been well studied.

The serious concerns listed in the data relate to inhaled crystalline silicon dust in industrial settings — not relevant to this oral powder — and to high silicon levels in patients on dialysis. Choline is generally safe in food amounts, but high-dose supplements can cause side effects.

Doses above 3.5 grams daily may cause fishy body odor, and very high doses (at least 9 grams daily) have caused diarrhea, nausea, sweating, and vomiting. Both silicon and choline are rated Likely Safe during pregnancy and breastfeeding, though choline needs are higher when breastfeeding — use only as your doctor advises.

Side effects, ingredient by ingredient Silicon Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take atropine or other anticholinergic medications — choline in this product may reduce their effects. For all other medications, no interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

BioSil might help with bone strength if you're at risk for osteoporosis, though the evidence is modest. If you take atropine (anticholinergic) medications, check with your doctor or pharmacist before starting.

For everyone else, it's generally well tolerated — just be aware that very high doses of choline can cause stomach upset and a fishy smell. Talk it over with your doctor or pharmacist to see if it fits your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BioSil, straight from the product label.

Brand Natural Factors
Barcode (UPC) 5425010391965
Net contents 60 Convenient Stick Packet(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220073
Product type Single Vitamin And Mineral
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BioSil by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Stick Pack(s)
Maximum serving Sizes:
1 Stick Pack(s)
Servings per container
60
UPC/BARCODE
5425010391965
IngredientAmount% DV
Silicon5 mg--
Choline100 mg18%

Other ingredients: Sugar, modified Starch, Ascorbic Acid, Orange flavor, Sodium Chloride, Calcium Phosphate, Stevia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clinically proven New

Formula

original ch-OSA formula

Collagen: reduces fine lines and wrinkles. Elastin: tightens skin and gives it "bounce back". Keratin: increases hair thickness and strength, strengthens nails.

After age 21, collagen levels decline by 1.0-1.5% every year. BioSil is clinically proven to increase collage formation. Best of all, BioSil works through your body's natural collagen-generating pathways. That's why all the collagen you gain with BioSil has your own DNA fingerprint. You have our assurance that it is never promoted through foreign animal sources.

Formulation

Generate your own collagen naturally Beautiful skin, hair and nails Healthy bones and joints

ch-OSA has been tested in rigorous double-blind placebo controlled clinical trials for both efficacy and safety. The results are published in peer review medical journals (see insert for details).

This product does not contain soy, diary, egg, wheat, gluten, fish/shellfish, nuts/tree nuts.

Ethically produced BioSil is created by leading collagen researchers and maintains the highest ethical standards from formulation to manufacturing. Sustainably sourced Manufactured in solar powered facility MWU (minimal water use) compliant

No artificial colors Non-GMO

No animal parts or sea organisms

Increase your 3 beauty proteins The condition of your hair, skin, and nails depends on three proteins, known as your "3 beauty proteins" BioSil increases all three.

V vegan

Clinically proven results BioSil has been clinically proven in double-blind, placebo-controlled clinical trials. Results are published in prestigious peer-reviewed medical journals, all with a high citation index. Reduces fine line & wrinkles Increases skin elasticity Thickens & strengthens hair Strengthens nails Promotes healthy bones & joints Increases collagen formation Helps protect existing collagen Advanced collagen generator

You have our assurance that it is never promoted through foreign animal sources.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Mix 1 stick packet in at least 3 fl. oz. of liquid, stir and drink.

Clinical Facts Choline-stabilized orthosilicic acid (ch-OSA) Clinically proven dosage ch-OSA Clinically Proven 1 stick packet, 2 times daily

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Keep out of the reach of children.

Storage

Store at 59-86 degrees F (15-30 degrees C). Protect from light and moisture.

Brand IP Statement(s)

ch-OSA, BioSil, the ch-OSA logo, the vegetarian logo, and Advanced Collagen Generator are registered trademarks of Bio Minerals NV. The Clinical Facts box is a trademark of Bio Minerals NV. 2019 Bio Minerals NV

U.S. Patents 7.968.528 and other patents pending.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BioSil by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BioSil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BioSil by Natural Factors

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Stick Pack(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Silicon

No known
interactions
5 mg per serving Form: Choline-stabilized Orthosilicic Acid

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silicon monograph & interactions

Choline

Interacts with
16 drugs
100 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Sugar, Modified Starch, Ascorbic Acid, Orange flavor, Sodium Chloride, Calcium Phosphate, Stevia. These complete the product’s ingredient list but are not active constituents.

Interaction report

BioSil by Natural Factors Drug Interactions

Want to check YOUR meds against BioSil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in BioSil interact with 16 drugs. Click any drug to see the details.

1 of the 2 ingredients in BioSil interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in BioSil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BioSil, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors
Street Address
14224 167th Street SE
City
Monroe
State
WA
ZipCode
98272
Pharmacist Counseling Corner

BioSil by Natural Factors: Common Questions

Does BioSil by Natural Factors interact with any medications?
Yes. Based on its ingredients, BioSil has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BioSil contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Both silicon and choline are rated Likely Safe during pregnancy and lactation. Choline is actually important while breastfeeding — your needs go up. Talk with your doctor about the right dose for you during this time.
What does choline do?
Choline is an essential nutrient your body uses for cell function, brain health, and liver health. It's naturally present in foods like eggs and fish, and your body can make some on its own.
Will this help my hair or my teeth?
Silicon hasn't been studied enough to know whether it helps with hair loss or gum health around dental implants. The evidence for those uses isn't established.
What side effects might I have?
In normal amounts, BioSil is generally well tolerated. Very high doses of choline can cause fishy body odor, and doses above 9 grams daily may cause nausea, vomiting, or diarrhea — but this powder isn't formulated at those extreme levels.
Is silicon safe to swallow?
Yes, silicon from food and supplements taken by mouth is safe and well tolerated. The serious lung problems listed in the data come from breathing crystalline silicon dust in industrial jobs, not from swallowing it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BioSil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BioSil label
Go deeper

The Full Monographs Behind BioSil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

BioSil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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