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Dietary supplement

Black Henna Ingredients & Drug Interactions

by Herbal Terra

Black Henna label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Henna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Henna is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for hair and skin dye, cooling and skin care, wound and skin healing (traditional).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Henna Extract, Dry, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Black Henna by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Henna by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Black Henna by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Black Henna Extract in dry, powdered form, suspended in a liquid base of alcohol, water, and glycerin.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Henna product and its label doesn't state a use — see Henna's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for henna isn't established in the data we hold. It's been studied for chemotherapy-induced peripheral neuropathy (nerve damage from cancer treatment), contact dermatitis (allergic skin irritation), chemotherapy-induced acral erythema (redness of the hands and feet), and wound healing — but all those ratings come back as insufficient reliable evidence to rate it.

The evidence, ingredient by ingredient Henna

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's where we need to be direct: the safety data here raises real concerns. Topical use on skin or hair of natural henna is generally low-risk, but oral henna — and especially 'black henna' products — can be harmful.

Orally, henna has been linked to stomach upset, rhabdomyolysis (muscle breakdown), kidney injury and failure, hemolytic anemia (breakdown of red blood cells), and death. Topically, it can cause allergic contact dermatitis with redness, itching, burning, swelling, and blistering — especially if it contains para-phenylenediamine (PPD), a compound added to 'black' henna to darken it.

The safety data also notes a concern for people with G6PD deficiency (a genetic blood condition), who may develop hemolysis. Because this is a liquid extract marketed as an oral product, and because little safety data exists for medicinal or oral use, you should avoid it and check with your doctor first.

Henna is rated unsafe in pregnancy and lactation.

Side effects, ingredient by ingredient Henna

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Henna.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your doctor before starting this product — henna may reduce how your body clears lithium and increase its levels in your blood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Natural henna applied topically to skin or hair has a long history, but oral products and 'black henna' carry documented risks — including serious kidney and blood problems. This liquid extract appears designed for oral use, which the safety data advises against.

Talk to your doctor or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Henna, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7238361159386
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 324821
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Henna by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
7238361159386
IngredientAmount% DV
Black Henna Extract, Dry, Powder983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

Organic alcohol

No artificial ingredients, color additives, fillers or binders.

Natural Gluten free

Formula

Indigofera tinctoria

Organic alcohol

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA

General Statements

Organic raw material.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Henna by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Henna label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Henna by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Black Henna Extract, Dry, Powder

Interacts with
1 drug
983 mg per serving Form: Indigofera tinctoria Extract, Dry, Powder

Henna is a plant most widely used as a natural dye for hair, skin, and nails, and has a long history in traditional medicine for skin and minor wound...

Black Henna Extract, Dry, Powder monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Henna by Herbal Terra Drug Interactions

Want to check YOUR meds against Black Henna?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Black Henna Extract, Dry, Powder 1

Individual Drug Interactions

The ingredients in Black Henna interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Black Henna interact with drugs. Each result below shows which ingredient is responsible. Black Henna Extract, Dry, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Henna with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Henna Extract, Dry, Powder1 drug type · 1 drug

Lithium

Henna is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, henna might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Black Henna Extract, Dry, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Henna, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Black Henna by Herbal Terra: Common Questions

Does Black Henna by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Black Henna has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Henna contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take by mouth?
The safety data advises against medicinal or oral use of henna. Oral henna has been linked to stomach upset, kidney injury, blood cell breakdown, and in rare cases, death. Because this is a liquid extract, it appears to be an oral product, so you should avoid it and talk with your doctor first.
Can I use this if I have G6PD deficiency?
No. Henna has been associated with hemolysis (breakdown of red blood cells) in people with G6PD deficiency, both topically and orally. If you have this genetic blood condition, you should not use henna products.
Is it safe during pregnancy or breastfeeding?
No. Henna is rated unsafe during pregnancy and lactation. If you're pregnant or breastfeeding, do not use this product.
What is this product supposed to do?
The evidence for what henna does isn't established in the data we hold. It's been studied for nerve pain from cancer treatment, allergic skin reactions, and wound healing, but all those studies show insufficient evidence to rate it.
What's the difference between 'black henna' and regular henna?
Black henna is regular henna with an added dye called para-phenylenediamine (PPD) to make it darker. PPD isn't found naturally in henna and is known to trigger allergic skin reactions — redness, itching, blistering, and scarring. Most allergic reactions reported to henna products actually come from PPD, not the henna itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Henna label
Go deeper

The Full Monographs Behind Black Henna’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Henna

Interacts with 1 drug

Henna is a plant most widely used as a natural dye for hair, skin, and nails, and has a long history in traditional medicine for skin and minor wound care. Strong human evidence for medicina...

Read the full Henna monograph →
Sources

Sources & How We Checked

Black Henna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Henna 30 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Lyon MJ, Shaw JC. Allergic contact dermatitis reaction to henna. Arch Dermatol 2000;136:124-5. PubMed
  4. Garcia Ortiz JC, Terron M, Bellido J. Contact allergy to henna. Int Arch Allergy Immunol 1997;114:298-9. PubMed
  5. Kandil HH, al-Ghanem MM, Sarwat MA, al-Thallab FS. Henna (Lawsonia inermis Linn.) inducing haemolysis among G6PD-deficient newborns. A new clinical observation. Ann Trop Paediatr 1996;16:287-91. PubMed
  6. Majoie IM, Bruynzeel DP. Occupational immediate-type hypersensitivity to henna in a hairdresser. Am J Contact Dermat 1996;7:38-40. DOI
  7. Lewin PK. Temporary henna tattoo with permanent scarification. CMAJ 1999;160:310.
  8. Lestringant GG, Bener A, Frossard PM. Cutaneous reactions to henna and associated additives. Br J Dermatol 1999;141:598-600. PubMed
  9. Etienne A, Piletta P, Hauser C, Pasche-Koo F. Ectopic contact dermatitis from henna. Contact Dermatitis 1997;:183. PubMed
  10. Wantke F, Gotz M, Jarisch R. Contact dermatitis due to henna, solvent red 1 and solvent red 3, a case report. Contact Dermatitis 1992;27:346-7. PubMed
  11. Nigam PK, Saxena AK. Allergic contact dermatitis from henna. Contact Dermatitis 1988;18:55-6. PubMed
  12. Gupta BN, Mathur AK, Agarwal C, Singh A. Contact sensitivity to henna. Contact Dermatitis 1986;15:303-4. PubMed
  13. Pasricha JS, Gupta R, Panjwani S. Contact dermatitis to henna (Lawsonia). Contact Dermatitis 1980;6:288-9. PubMed
  14. Cronin E. Immediate type hypersensitivity to henna. Contact Dermatitis 1979;5:198-9. PubMed
  15. Raupp P, Hassan JA, Varughese M, Kristiansson B. Henna causes life threatening haemolysis in glucose-6-phosphate dehydrogenase deficiency. Arch Dis Child 2001;85:411-2.. PubMed
  16. Akpolat ND, Aras A. Local hypertrichosis: A rare complication of a temporary henna tattoo. Turk J Pediatr. 2016;58(4):413-414. PubMed
  17. Goldscheider I, Herzinger T, Varga R, et al. Childhood lichen planus pemphigoides: report of two cases treated successfully with systemic glucocorticoids and dapsone. Pediatr Dermatol. 2014;31(6):751-3. PubMed
  18. Ilyas S, Wasif K, Saif MW. Topical henna ameliorated capecitabine-induced hand-foot syndrome. Cutan Ocul Toxicol. 2014;33(3):253-5. PubMed
  19. Katar S, Devecioglu C, Ozbek MN, Ecer S. Henna causes life-threatening hyperbilirubinaemia in glucose-6-phosphate dehydrogenase deficiency. Clin Exp Dermatol. 2007;32(2):235-6. PubMed
  20. Kheir A, Gaber I, Gafer S, Ahmed W. Life-threatening haemolysis induced by henna in a Sudanese child with glucose-6-phosphate dehydrogenase deficiency. East Mediterr Health J. 2017;23(1):28-30.
  21. Khine YY. Acute Kidney Injury following Ingestion of Henna Leaf Extract: A Case Report from Myanmar. Blood Purif. 2017;44 Suppl 1:41-45. PubMed
  22. Kind F, Scherer K, Bircher AJ. Contact dermatitis to para-phenylenediamine in hair dye following sensitization to black henna tattoos - an ongoing problem. J Dtsch Dermatol Ges. 2012;10(8):572-8. PubMed
  23. Rund D, Schaap T, Da'as N, Ben Yehuda D, Kalish J. Plasma exchange as treatment for Lawsone (henna) intoxication. J Clin Apher. 2007;22(4):243-5. PubMed
  24. Uygur-Bayramicli O, Dabak R, Sargin M. Acute chemical colitis resulting from oral intake of henna. J Clin Gastroenterol. 2005;39(10):920-1. PubMed
  25. Poursadra E, Anvari-Tafti M, Dehghani A, Eghbali-Babadi M, Rafiei Z. Comparing the effect of henna oil and olive oil on pressure ulcer grade one in intensive care units patients. Adv Biomed Res. 2019 Nov 27;8:68. PubMed
  26. Zibanejad S, Miraj S, Rafieian Kopaei M. Healing effect of Quercus persica and Lawsonia inermis ointment on episiotomy wounds in primiparous women. J Res Med Sci. 2020 Feb 20;25:11. PubMed
  27. Kubat S, Aksu H, Hasbal NB. Acute renal failure due to henna stone ingestion as a remedy of diabetes. Nefrologia. 2020 Jul 20:S0211-6995(20)30083-7. PubMed
  28. Asgari S, Esfandbod M, Haghshomar M. Henna-induced hemolysis and acute kidney injury in an 85-year-old man; A case report. Arch Acad Emerg Med. 2020 Oct 14;8(1):e82.
  29. Niazi M, Mehrabani M, Namazi MR, et al. Efficacy of a topical formulation of henna (Lawsonia inermis L.) in contact dermatitis in patients using prosthesis: A double-blind randomized placebo-controlled clinical trial. Complement Ther Med. 2020 Mar;49:1023 PubMed
  30. Arslan S, Zorba Bahceli P, Ilik Y, Artaç M. The preliminary effects of henna on chemotherapy-induced peripheral neuropathy in women receiving oxaliplatin-based treatment: A parallel-group, randomized, controlled pilot trial. Eur J Oncol Nurs. 2020 Oct;48: PubMed

See these in context on the Henna monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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