Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Bladderex Ingredients & Drug Interactions

by EB Earth's Bounty

Bladderex label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bladderex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bladderex is a dietary supplement by EB Earth's Bounty with 5 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 417 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Poria. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bladderex by EB Earth's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Bladderex by EB Earth's Bounty — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bladderex by EB Earth's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend (Combination)” is a proprietary blend — the label gives one combined amount (1,150 mg) without saying how much of each component you get.

Bladderex contains 5 active ingredients: corn, pyrrosia, a proprietary blend, coin-leaf desmodium, and lesser speargrass, plus poria mushroom (also called poria mushroom extract). The product also contains inactive ingredients — dicalcium phosphate, stearic acid, acacia gum, silicon dioxide, and rice extract — which serve as binders, flow agents, and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Poria Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: herbal bladder relief.
  • We looked for evidence on: Urinary tract infections (UTIs), Urinary incontinence, Overactive bladder, Bladder irritation.
  • The closest evidence on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs) (Natural Medicines).

Effectiveness data for the ingredients in Bladderex aren't well established in the sources we hold. For poria mushroom specifically, the evidence is insufficient to rate it reliably for the conditions it's studied in — cancer, chronic fatigue syndrome, dementia, diabetes, diabetic kidney disease, and diarrhea.

The other ingredients in this product have no effectiveness ratings on file.

The evidence, ingredient by ingredient Poria Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Poria mushroom is generally well tolerated based on traditional use, but human safety data are limited. Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma.

The safety data advises against poria mushroom during pregnancy, and avoidance is recommended while breastfeeding because there isn't enough reliable safety information. For the other ingredients in Bladderex, we don't hold pregnancy or breastfeeding safety data — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, nursing, or planning to be.

Side effects, ingredient by ingredient Poria Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Poria Mushroom.
  • The most serious interaction on file is rated Moderate.
  • For scale: 417 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bladderex, double-check with your doctor or pharmacist if you take sedatives or CNS depressants (medications that slow your nervous system), anticholinergic drugs (medications that block certain nerve signals), or cholinergic drugs (medications that enhance those signals). These carry Moderate-severity interactions with poria mushroom in this product.

For all other ingredients, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bladderex might be worth considering if you're looking for herbal bladder support, but only after checking your medications. If you take sedatives or any drugs that affect nerve signals, clear it first with your doctor or pharmacist.

The effectiveness evidence for its ingredients isn't well established, and the safety data are limited — this is one to discuss with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bladderex, straight from the product label.

Brand EB Earth's Bounty
Barcode (UPC) 707990106001
Net contents 40 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2018
DSLD ID 82800
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bladderex by EB Earth's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
20
UPC/BARCODE
707990106001
IngredientAmount% DV
Corn0 NP--
Pyrrosia0 NP--
Proprietary Blend (Combination)1150 mg--
Coin-Leaf Desmodium0 NP--
Lesser Speargrass0 NP--
Poria0 NP--

Other ingredients: Dicalcium Phosphate, Stearic Acid, Acacia Gum, Silicon Dioxide, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The herbs in Bladderex have been carefully selected for their traditional safe and swift ability to help you achieve the desired results. The are infused with subtle energy, maximizing the benefits for you. Satisfaction guaranteed.

Fastest acting formula! Herbal bladder relief

Please recycle

No BPA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, treat or prevent disease.

General

Product #1060 BX9

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 2 tablets 3 times daily or as directed by your health care professional.

Precautions

Do not exceed recommended dosage.

See your health care professional for any medical condition.

Do not use if pregnant or nursing.

Formulation

Gluten & GMO free. Contains no added sugars, yeast, wheat, dairy, soy.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bladderex by EB Earth's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bladderex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bladderex by EB Earth's Bounty

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend (Combination)

1150 mg per serving
  • › Corn
  • › Pyrrosia
  • › Coin-Leaf Desmodium
  • › Lesser Speargrass
  • › Poria

Other (inactive) ingredients: Dicalcium Phosphate, Stearic Acid, Acacia Gum, Silicon Dioxide, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bladderex by EB Earth's Bounty Drug Interactions

Want to check YOUR meds against Bladderex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
417Drugs
417 Moderate

Ingredients driving the most interactions

Poria 417

Individual Drug Interactions

The ingredients in Bladderex interact with 417 drugs. Click any drug to see the details.

1 of the 5 ingredients in Bladderex interact with drugs. Each result below shows which ingredient is responsible. Poria

Each ingredient & the kinds of drugs it affects

For each ingredient in Bladderex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Poria3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bladderex, from the product label.

EB Earth's Bounty

See all EB Earth's Bounty products
Name
Earth's Bounty
City
Vancouver
State
WA
ZipCode
98682
Phone Number
800-736-5609
Web Address
www.earthsbounty.com
Pharmacist Counseling Corner

Bladderex by EB Earth's Bounty: Common Questions

Does Bladderex by EB Earth's Bounty interact with any medications?
Yes. Based on its ingredients, Bladderex has a known interaction with 417 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bladderex contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Bladderex if I'm pregnant or breastfeeding?
The safety data advise against poria mushroom during pregnancy, and avoidance is recommended while breastfeeding. For the other ingredients, we don't hold pregnancy or breastfeeding safety information. Talk with your doctor or pharmacist about whether this product is right for you in either situation.
What is poria mushroom supposed to do?
Poria mushroom is included in this product, but the evidence to rate its effectiveness for conditions like diabetes, diarrhea, or dementia is insufficient. We hold no established claims about what it does for bladder health specifically.
Has this product been tested in humans?
Poria mushroom is generally well tolerated based on traditional use, but human safety data are limited. The other ingredients in Bladderex haven't been checked by us. The interactions documented for poria mushroom come from animal research, not human trials.
Are there any side effects I should know about?
Allergic reactions to poria mushroom have been reported rarely, including allergic rhinitis and allergic asthma. Beyond that, human safety data are limited. If you have a known allergy to mushrooms, mention this to your doctor or pharmacist.
Does this product contain fillers or extra ingredients?
Yes, Bladderex contains inactive ingredients: dicalcium phosphate, stearic acid, acacia gum, silicon dioxide, and rice extract. These serve as binders, flow agents, and tablet stabilizers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bladderex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bladderex label
Go deeper

The Full Monographs Behind Bladderex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph →
Sources

Sources & How We Checked

Bladderex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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