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Dietary supplement

BladderSense Ingredients & Drug Interactions

by Natural Factors WS WomenSense

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

BladderSense is a dietary supplement by Natural Factors WS WomenSense with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BladderSense by Natural Factors WS WomenSense

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

BladderSense contains one active ingredient: pumpkin seed extract. In its concentrated form, it's been studied for bladder and urinary health, though the evidence for most of those uses is still being built.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support bladder function frequency tone control.
  • We looked for evidence on: Overactive bladder, urinary frequency, urinary urgency, bladder control.
  • The closest evidence on file: Pumpkin is rated "Insufficient Reliable Evidence To Rate" for Overactive bladder (Natural Medicines).

The evidence for pumpkin seed extract is strongest for benign prostatic hyperplasia (BPH), an enlarged prostate — it's rated possibly effective for that. For other uses — including androgenic alopecia (pattern hair loss), interstitial cystitis (bladder pain), parasitic infections, and urinary tract infections — the evidence isn't yet established in the data we hold.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin seed extract is generally well tolerated in most adults. The most common side effects from oral use are mild: abdominal discomfort, diarrhea, nausea, and vomiting.

Anaphylaxis (a severe allergic reaction) is rare. There are two case reports of hair loss in the weeks after eating meals containing high amounts of bitter pumpkin or squash, thought to be due to a compound called cucurbitacin — but this is very uncommon.

For pregnancy and breastfeeding, there isn't enough data on concentrated pumpkin seed supplements to know whether they're safe; talk it over with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your doctor or pharmacist before starting BladderSense. Pumpkin seed extract may increase lithium levels in your body, and your dose may need adjustment.

No other interactions are documented in our data for the ingredient we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

BladderSense may help if you're dealing with an enlarged prostate. The main caution is if you take lithium — you'll want to flag this with your doctor or pharmacist before starting, since the dose might need adjusting.

For other uses listed on the label, the evidence is still thin, so have a conversation with your healthcare provider about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BladderSense, straight from the product label.

Brand Natural Factors WS WomenSense
Barcode (UPC) 068958049779
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 76609
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BladderSense by Natural Factors WS WomenSense, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
068958049779
IngredientAmount% DV
Pumpkin seed extract262 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass Spec Documentation - Lab tested

Purity & potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule 1-3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

WomenSense is a line of products dedicated to helping women reach their full health potential.

BladderSense contains the highly absorbable water-soluble pumpkin seed extract to support bladder function including frequency, tone, and control.

General Statements

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Urinary formula

Supports healthy bladder function

Product of Canada Recyclable container and label.

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal parts, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Non GMO - Gluten free

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

R0

FDA Statement of Identity

Dietary Supplement

See for yourself

BladderSense by Natural Factors WS WomenSense label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BladderSense by Natural Factors WS WomenSense

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pumpkin seed extract

Interacts with
1 drug
262 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

BladderSense by Natural Factors WS WomenSense Drug Interactions

Want to check YOUR meds against BladderSense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in BladderSense with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin seed extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for BladderSense, from the product label.

Natural Factors WS WomenSense

See all Natural Factors WS WomenSense products
Name
Natural Factors Canada
Pharmacist Counseling Corner

BladderSense by Natural Factors WS WomenSense: Common Questions

Does BladderSense by Natural Factors WS WomenSense interact with any medications?
Yes. Based on its ingredients, BladderSense has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BladderSense contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pumpkin seed extract and what is it supposed to do?
Pumpkin seed extract is a concentrated form of compounds from pumpkin seeds. It's been studied mainly for benign prostatic hyperplasia — an enlarged prostate in men — where the evidence suggests it may help. The evidence for other uses, like bladder pain or UTI prevention, isn't yet clear.
What are the side effects I should watch for?
Most people tolerate it well. The most common side effects are mild: stomach discomfort, diarrhea, nausea, or vomiting. Severe allergic reactions are very rare. There are also two old case reports of hair loss after eating very high amounts of bitter pumpkin, but that's not common.
Is it safe to take if I'm pregnant or breastfeeding?
There isn't enough data on concentrated pumpkin seed supplements during pregnancy or breastfeeding to say either way. Talk with your doctor or pharmacist — they can help you decide what makes sense for your situation.
Does it actually work for urinary tract infections or bladder problems?
The evidence isn't established yet for those uses. Pumpkin seed extract is rated possibly effective for enlarged prostate, but for UTI prevention, bladder pain, and other urinary issues, we don't have solid proof yet.
What's in the capsule besides the pumpkin seed extract?
The capsule itself is vegetarian, and the filler ingredients are microcrystalline cellulose, magnesium stearate, and silica — all common inactive ingredients that hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BladderSense is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BladderSense label
Sources

Sources & How We Checked

BladderSense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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