No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Bloodroot Ingredients & Drug Interactions

by Herb Pharm

Bloodroot label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bloodroot against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Bloodroot is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for skin growths, moles, and warts (topical), dental plaque and gum health, sore throat and cough (traditional).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Bloodroot by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bloodroot rhizome (Sanguinaria canadensis) extract, supplied as a liquid. The extract is preserved in certified organic cane alcohol and distilled water with dilute hydrochloric acid as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: dental plaque and gum health support.
  • We looked for evidence on: Dental plaque, Gingivitis, Periodontitis, Oral health, Tooth health.
  • The strongest evidence on file: Bloodroot is rated "Possibly Effective" for Dental plaque (Natural Medicines).
  • Also on file: Bloodroot is rated "Possibly Effective" for Gingivitis.
  • Also on file: Bloodroot is rated "Insufficient Reliable Evidence To Rate" for Periodontitis.

Bloodroot is rated possibly effective for dental plaque and gingivitis (gum inflammation). The evidence for periodontitis (deeper gum infection) is insufficient to rate.

The data we hold doesn't establish effectiveness for any other uses.

The evidence, ingredient by ingredient Bloodroot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bloodroot is generally well tolerated at appropriate oral doses used short term, but nausea, vomiting, and central nervous system depression have been reported. Higher oral doses can cause a dangerous drop in blood pressure, shock, and coma.

Long-term use in toothpaste or mouthwash is linked to mouth lesions, impaired taste, and staining. Skin contact with fresh bloodroot causes irritation and contact dermatitis; topical application can corrode skin, produce severe pain and burning, and leave permanent scarring.

The product carries explicit safety warnings: avoid bloodroot for self-treatment because it is potentially toxic and corrosive. Avoid during pregnancy—it may be toxic and its safety is not established.

Avoid while breastfeeding due to lack of safety data and potential toxicity.

Side effects, ingredient by ingredient Bloodroot

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, this product's safety profile is the real concern here, and you should discuss it with your pharmacist or doctor before starting.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Bloodroot has limited evidence behind it and carries serious toxicity and corrosive risks that the manufacturer itself warns against self-treatment. If you're thinking about using it for gum health or dental issues, talk with your dentist or pharmacist first—there are safer, better-studied options available.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bloodroot, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700001124
Net contents 4 fl. Oz.; 120 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50096
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bloodroot by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.45 mL
Maximum serving Sizes:
0.45 mL
Servings per container
264
UPC/BARCODE
090700001124
IngredientAmount% DV
Bloodroot rhizome (Sanguinaria canadensis) extract407 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water, dilute Hydrochloric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Shake well before using Add 0.45 ml (20 drops) to 8 oz. of water or juice, two to four times per day. Best taken between meals.

Precautions

Caution: Seek expert medical advice before taking during pregnancy.

Keep out of the reach of children

Storage

Store away from heat & light

General Statements

whole rhizome

Optimal well-being

Dry herb/menstruum ratio: 1:10

FDA Statement of Identity

Herbal Supplement

Formula

Bloodroot liquid extract

Formulation

Gluten-Free

We prepare our Bloodroot Extract from the rhizome of Certified Organically Grown Sanguinaria canadensis plants.

General

010

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bloodroot by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bloodroot label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bloodroot by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.45 mL Dosage formLiquid Servings per container264 Amounts shown are per serving.

Bloodroot rhizome (Sanguinaria canadensis) extract

No known
interactions
407 mg per serving

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, bu...

Bloodroot rhizome (Sanguinaria canadensis) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water, Dilute Hydrochloric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bloodroot by Herb Pharm Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Bloodroot. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Bloodroot, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Bloodroot by Herb Pharm: Common Questions

Does Bloodroot by Herb Pharm interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Bloodroot. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Bloodroot contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bloodroot safe to use on my skin?
No. Skin contact with bloodroot causes irritation and dermatitis. Topical application can corrode skin, cause severe pain and burning, and leave permanent scarring. The manufacturer warns against self-treatment because bloodroot is potentially toxic and corrosive.
Can I use this while pregnant or breastfeeding?
You should avoid it. Bloodroot is rated likely unsafe in pregnancy because it may be toxic and its safety is not established. While breastfeeding, it's rated possibly unsafe due to lack of safety data and potential toxicity. Talk with your doctor or pharmacist about safer options.
Does bloodroot really work for gum disease?
Bloodroot is rated possibly effective for dental plaque and gingivitis, so there's some evidence. However, the evidence for periodontitis is insufficient to rate. Given the serious safety concerns, ask your dentist about proven alternatives first.
What side effects can bloodroot cause?
At appropriate doses taken short term, nausea, vomiting, and drowsiness have been reported. Higher doses can cause dangerously low blood pressure, shock, and coma. Long-term use in mouthwash or toothpaste can cause mouth lesions, taste changes, and tooth staining.
What's in this liquid besides the active ingredient?
The extract is suspended in certified organic cane alcohol and distilled water, with dilute hydrochloric acid added as a preservative.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bloodroot is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bloodroot label
Go deeper

The Full Monographs Behind Bloodroot’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bloodroot

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, but there is no good evidence it safely tr...

Read the full Bloodroot monograph →
Sources

Sources & How We Checked

Bloodroot's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bloodroot 17 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Tenenbaum, H., Dahan, M., and Soell, M. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol. 1999;70(3):307-311. PubMed
  6. Eversole, L. R., Eversole, G. M., and Kopcik, J. Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 2000;89(4):455-464. PubMed
  7. Allen, C. L., Loudon, J., and Mascarenhas, A. K. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen.Dent. 2001;49(6):608-614.
  8. Kopczyk, R. A., Abrams, H., Brown, A. T., Matheny, J. L., and Kaplan, A. L. Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 months of use. J.Periodontol. 1991;62(10):617-622. PubMed
  9. Harper, D. S., Mueller, L. J., Fine, J. B., Gordon, J., and Laster, L. L. Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. J.Periodontol. 1990;61(6):352-358. PubMed
  10. Kuftinec, M. M., Mueller-Joseph, L. J., and Kopczyk, R. A. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. J.Can.Dent.Assoc. 1990;56(7 Suppl):31-33.
  11. Frankos, V. H., Brusick, D. J., Johnson, E. M., Maibach, H. I., Munro, I., Squire, R. A., and Weil, C. S. Safety of Sanguinaria extract as used in commercial toothpaste and oral rinse products. J.Can.Dent.Assoc. 1990;56(7 Suppl):41-47.
  12. Cullinan, M. P., Powell, R. N., Faddy, M. J., and Seymour, G. J. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Aust.Dent.J. 1997;42(1):47-51. PubMed
  13. Affleck, A. G. and Varma, S. A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet. Br.J Dermatol 2007;157(5):1078-1079. PubMed
  14. Cienki JJ, Zaret L. An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med. 2010;16(10):1125-7. PubMed
  15. Hou JL, Brewer JD. Black salve and bloodroot extract in dermatologic conditions. Cutis. 2015;95(6):309-11.
  16. Schilling LM, Saedi N. Bloodroot paste: what dermatologists and patients need to know. Dermatol Surg 2016;42(10):1223-4. PubMed
  17. Schlichte MJ, Downing CP, Ramirez-Fort M, Gordon R, Tyring S. Bloodroot associated eschar. Dermatol Online J 2014;20(7). DOI

See these in context on the Bloodroot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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