No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Bloodroot Ingredients & Drug Interactions

by Herbalist & Alchemist

Bloodroot label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bloodroot against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Bloodroot is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for skin growths, moles, and warts (topical), dental plaque and gum health, sore throat and cough (traditional).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Bloodroot by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Bloodroot Extract, Dried. Bloodroot is a plant used historically for oral health, particularly for dental plaque and gingivitis.

The liquid form also includes ethyl alcohol, distilled water, and apple cider vinegar as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Bloodroot's overall clinical evidence instead.

Moderate

Some clinical evidence supports Bloodroot for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dental plaque — rated "Possibly Effective" (Natural Medicines).
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).

Bloodroot shows possibly effective evidence for dental plaque and gingivitis. For periodontitis (deeper gum infection), we don't have enough reliable evidence to rate it one way or the other.

That's the extent of what the data shows — limited support for plaque and mild gum inflammation, but not for more serious gum disease.

The evidence, ingredient by ingredient Bloodroot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bloodroot is generally well tolerated at appropriate doses taken short-term, but the safety concerns are real and significant. Nausea, vomiting, and drowsiness have been reported; higher doses can cause dangerously low blood pressure (hypotension), shock, and coma.

Long-term use in toothpaste or mouthwash has been tied to mouth sores, taste problems, and staining of teeth and tongue. Topically, fresh bloodroot can burn and corrode skin, leaving scars.

Because bloodroot is potentially toxic and corrosive, we don't recommend it for self-treatment. Avoid it during pregnancy — it may be toxic and its safety isn't established.

Avoid it while breastfeeding too, due to lack of safety data and potential toxicity.

Side effects, ingredient by ingredient Bloodroot

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That does not mean interactions don't exist — it means we have no monograph data linking bloodroot to specific drugs.

Before you use this product, run it and any prescriptions you take through the medication checker on this page.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

Bloodroot has possibly effective evidence for dental plaque and gingivitis, but its serious safety profile — toxicity, corrosiveness, and risk of harm with longer use — makes it a supplement we recommend discussing with your pharmacist or doctor before considering. This isn't a casual over-the-counter choice.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bloodroot, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056103217
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 297462
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bloodroot by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 mL
Maximum serving Sizes:
0.25 mL
Servings per container
240
UPC/BARCODE
667056103217
IngredientAmount% DV
Bloodroot Extract, Dried0.25 mL--

Other ingredients: Ethyl Alcohol, distilled Water, Apple Cider Vinegar

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Sanguinaria canadensis

OK (Kosher)

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 2-5 drops (0.10-0.25 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Contraindications: Do not use during pregnancy or lactation.

May cause nausea and vomiting. Use under the supervision of a qualified expert.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

OK (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bloodroot by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bloodroot label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bloodroot by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.1 mL Dosage formLiquid Servings per container240 Amounts shown are per serving.

Bloodroot Extract, Dried

No known
interactions
0.25 mL per serving Form: Bloodroot extract, Dried, Bloodroot Extract, Dried

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, bu...

Bloodroot Extract, Dried monograph & interactions

Other (inactive) ingredients: Ethyl Alcohol, Distilled Water, Apple Cider Vinegar. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bloodroot by Herbalist & Alchemist Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Bloodroot. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Bloodroot, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Bloodroot by Herbalist & Alchemist: Common Questions

Does Bloodroot by Herbalist & Alchemist interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Bloodroot. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Bloodroot contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use bloodroot while pregnant or breastfeeding?
No. The safety data advises against bloodroot in pregnancy because it may be toxic and its safety is not established. Avoid it while breastfeeding too — there isn't enough safety data, and bloodroot carries potential toxicity concerns.
What side effects might I notice if I take bloodroot?
Short-term use at appropriate doses is generally well tolerated, but nausea, vomiting, and drowsiness have been reported. Higher doses risk low blood pressure, shock, and coma. Long-term use in toothpaste or mouthwash has been linked to mouth sores, taste problems, and tooth staining.
Does bloodroot actually work for gum disease?
It shows possibly effective evidence for dental plaque and gingivitis (mild gum inflammation). For more serious gum infection (periodontitis), we don't have enough reliable evidence to say whether it works.
Why do you say not to use bloodroot for self-treatment?
Bloodroot is potentially toxic and corrosive. It can cause serious harm — internally, dangerously low blood pressure or shock; on skin, it can burn, corrode, and leave permanent scars. This isn't a gentle home remedy.
What's in this product besides bloodroot?
The liquid form contains ethyl alcohol, distilled water, and apple cider vinegar as inactive ingredients to carry and preserve the extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bloodroot is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bloodroot label
Go deeper

The Full Monographs Behind Bloodroot’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bloodroot

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, but there is no good evidence it safely tr...

Read the full Bloodroot monograph →
Sources

Sources & How We Checked

Bloodroot's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bloodroot 17 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Tenenbaum, H., Dahan, M., and Soell, M. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol. 1999;70(3):307-311. PubMed
  6. Eversole, L. R., Eversole, G. M., and Kopcik, J. Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 2000;89(4):455-464. PubMed
  7. Allen, C. L., Loudon, J., and Mascarenhas, A. K. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen.Dent. 2001;49(6):608-614.
  8. Kopczyk, R. A., Abrams, H., Brown, A. T., Matheny, J. L., and Kaplan, A. L. Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 months of use. J.Periodontol. 1991;62(10):617-622. PubMed
  9. Harper, D. S., Mueller, L. J., Fine, J. B., Gordon, J., and Laster, L. L. Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. J.Periodontol. 1990;61(6):352-358. PubMed
  10. Kuftinec, M. M., Mueller-Joseph, L. J., and Kopczyk, R. A. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. J.Can.Dent.Assoc. 1990;56(7 Suppl):31-33.
  11. Frankos, V. H., Brusick, D. J., Johnson, E. M., Maibach, H. I., Munro, I., Squire, R. A., and Weil, C. S. Safety of Sanguinaria extract as used in commercial toothpaste and oral rinse products. J.Can.Dent.Assoc. 1990;56(7 Suppl):41-47.
  12. Cullinan, M. P., Powell, R. N., Faddy, M. J., and Seymour, G. J. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Aust.Dent.J. 1997;42(1):47-51. PubMed
  13. Affleck, A. G. and Varma, S. A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet. Br.J Dermatol 2007;157(5):1078-1079. PubMed
  14. Cienki JJ, Zaret L. An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med. 2010;16(10):1125-7. PubMed
  15. Hou JL, Brewer JD. Black salve and bloodroot extract in dermatologic conditions. Cutis. 2015;95(6):309-11.
  16. Schilling LM, Saedi N. Bloodroot paste: what dermatologists and patients need to know. Dermatol Surg 2016;42(10):1223-4. PubMed
  17. Schlichte MJ, Downing CP, Ramirez-Fort M, Gordon R, Tyring S. Bloodroot associated eschar. Dermatol Online J 2014;20(7). DOI

See these in context on the Bloodroot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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