No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Blood Root Ingredients & Drug Interactions

by Pure Herbs

Blood Root label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blood Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Blood Root is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for skin growths, moles, and warts (topical), dental plaque and gum health, sore throat and cough (traditional).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Blood Root by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bloodroot root extract. Bloodroot has been used traditionally in herbal medicine, particularly for oral health.

The liquid form allows for flexible dosing, though bloodroot carries real safety concerns — the plant contains sanguinarine, a compound that's toxic at excessive doses.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy gums.
  • We looked for evidence on: Dental plaque, Gingivitis, Periodontitis, gum disease, oral health.
  • The strongest evidence on file: Bloodroot is rated "Possibly Effective" for Dental plaque (Natural Medicines).
  • Also on file: Bloodroot is rated "Possibly Effective" for Gingivitis.
  • Also on file: Bloodroot is rated "Insufficient Reliable Evidence To Rate" for Periodontitis.

The evidence supporting bloodroot is limited. For dental plaque and gingivitis (gum inflammation), it's possibly effective — meaning there's some supporting evidence, but more research is needed.

For irritable bowel syndrome and periodontitis (advanced gum disease), we don't have reliable evidence to rate it one way or the other. If you're considering this for an oral health issue, talk it over with your dentist or doctor first.

The evidence, ingredient by ingredient Bloodroot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's where we need to be direct: bloodroot carries real safety risks. We advise against it for self-treatment because it's potentially toxic and corrosive.

Orally, it's generally well tolerated at appropriate doses for short periods, but nausea, vomiting, and nervous system depression have been reported. Higher doses can cause low blood pressure (hypotension), glaucoma, shock, and even coma.

Long-term use as a toothpaste or mouthwash has been linked to mouth sores, impaired taste, and permanent staining. Topically, it can burn, corrode skin, and leave scars.

Bloodroot is not safe during pregnancy (rated likely unsafe) or while breastfeeding (rated possibly unsafe). The safety data advises against both.

Side effects, ingredient by ingredient Bloodroot

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for bloodroot. However, because it can lower blood pressure, affect nervous system function, and raise eye pressure at higher doses, mention this product to your doctor or pharmacist before starting — especially if you take medications for blood pressure, mood, sleep, or glaucoma.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Bloodroot isn't something we recommend for self-care. While it may help with dental plaque or gum inflammation, the safety risks — especially with long-term use or higher doses — outweigh the modest evidence.

Pregnancy and breastfeeding are definite no's. If you're dealing with gum disease or plaque buildup, talk with your dentist or doctor about safer, better-studied options first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blood Root, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278833
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blood Root by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Bloodroot Root Extract1830 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Helps to support healthy gums.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blood Root by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blood Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blood Root by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Bloodroot Root Extract

No known
interactions
1830 mg per serving

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, bu...

Bloodroot Root Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blood Root by Pure Herbs Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Blood Root. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Blood Root, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Blood Root by Pure Herbs: Common Questions

Does Blood Root by Pure Herbs interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Blood Root. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Blood Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bloodroot safe to use long-term?
No. Long-term use — like daily toothpaste or mouthwash — has been tied to mouth sores, impaired taste, and permanent staining of your tongue and teeth. Keep use short-term and at appropriate doses only.
Can I use bloodroot while pregnant or breastfeeding?
No. The safety data advises against bloodroot in pregnancy because it may be toxic and isn't well studied. Breastfeeding is also not recommended due to lack of safety data and potential toxicity. Talk with your doctor or midwife about safer alternatives.
What are the most common side effects?
Orally, nausea, vomiting, and drowsiness can occur. Topically, burning, pain, skin irritation, and contact dermatitis are common — and it can cause scarring and skin erosion with prolonged contact. Higher oral doses carry the risk of serious effects like low blood pressure, glaucoma, shock, and coma.
Does bloodroot really work for dental plaque and gum disease?
It's possibly effective for dental plaque and gingivitis, meaning there's some evidence — but it's not definitive. For periodontitis (more advanced gum disease), the evidence isn't reliable enough to rate. Ask your dentist about safer, more proven options.
Why is sanguinarine a concern?
Sanguinarine is a toxic compound in bloodroot. At appropriate doses, short-term use is generally tolerated, but excessive doses can cause serious harm — including glaucoma, low blood pressure, shock, and coma. That's why we don't recommend this product for self-treatment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blood Root is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blood Root label
Go deeper

The Full Monographs Behind Blood Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bloodroot

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, but there is no good evidence it safely tr...

Read the full Bloodroot monograph →
Sources

Sources & How We Checked

Blood Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bloodroot 14 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Eversole, L. R., Eversole, G. M., and Kopcik, J. Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 2000;89(4):455-464. PubMed
  6. Allen, C. L., Loudon, J., and Mascarenhas, A. K. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen.Dent. 2001;49(6):608-614.
  7. Kuftinec, M. M., Mueller-Joseph, L. J., and Kopczyk, R. A. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. J.Can.Dent.Assoc. 1990;56(7 Suppl):31-33.
  8. Frankos, V. H., Brusick, D. J., Johnson, E. M., Maibach, H. I., Munro, I., Squire, R. A., and Weil, C. S. Safety of Sanguinaria extract as used in commercial toothpaste and oral rinse products. J.Can.Dent.Assoc. 1990;56(7 Suppl):41-47.
  9. Cullinan, M. P., Powell, R. N., Faddy, M. J., and Seymour, G. J. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Aust.Dent.J. 1997;42(1):47-51. PubMed
  10. Affleck, A. G. and Varma, S. A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet. Br.J Dermatol 2007;157(5):1078-1079. PubMed
  11. Cienki JJ, Zaret L. An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med. 2010;16(10):1125-7. PubMed
  12. Hou JL, Brewer JD. Black salve and bloodroot extract in dermatologic conditions. Cutis. 2015;95(6):309-11.
  13. Schilling LM, Saedi N. Bloodroot paste: what dermatologists and patients need to know. Dermatol Surg 2016;42(10):1223-4. PubMed
  14. Schlichte MJ, Downing CP, Ramirez-Fort M, Gordon R, Tyring S. Bloodroot associated eschar. Dermatol Online J 2014;20(7). DOI

See these in context on the Bloodroot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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