No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Bloodroot Ingredients & Drug Interactions

by Herb Stop

Bloodroot label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bloodroot against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Bloodroot is a dietary supplement by Herb Stop with 1 active ingredient. Its ingredients are commonly taken for skin growths, moles, and warts (topical), dental plaque and gum health, sore throat and cough (traditional).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Bloodroot by Herb Stop

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Bloodroot Extract. Bloodroot has been used traditionally in dental and oral products, though the evidence for its effectiveness is limited and its safety profile raises significant concerns.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy cellular function.
  • We looked for evidence on: Dental plaque, Gingivitis, Periodontitis, oral health, antimicrobial support, gum disease.
  • The strongest evidence on file: Bloodroot is rated "Possibly Effective" for Dental plaque (Natural Medicines).
  • Also on file: Bloodroot is rated "Possibly Effective" for Gingivitis.
  • Also on file: Bloodroot is rated "Insufficient Reliable Evidence To Rate" for Periodontitis.

The data shows bloodroot extract is possibly effective for dental plaque and gingivitis. For periodontitis, the evidence isn't reliable enough to rate it.

If you're considering this for oral health, talk with your dentist about whether it's right for your situation and what other options might work better.

The evidence, ingredient by ingredient Bloodroot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bloodroot is generally well tolerated when used orally in appropriate doses for short periods, but the risks outweigh the benefits for most people. Short-term oral use may cause nausea, vomiting, and drowsiness (central nervous system depression).

Higher doses can cause dangerously low blood pressure, shock, and coma. Long-term use of bloodroot toothpaste or mouthwash has been linked to mouth sores, taste changes, and tooth staining.

Topically, bloodroot can severely irritate or burn skin, cause deep scarring, and erode tissue — cases of people applying bloodroot salves for a few days report severe pain, burning, and permanent scarring. Do not use during pregnancy; bloodroot is likely unsafe.

Avoid while breastfeeding due to lack of safety data and potential toxicity.

Side effects, ingredient by ingredient Bloodroot

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we checked.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

We don't recommend bloodroot for self-treatment — the potential for serious harm is real, and safer alternatives exist for dental plaque and gum health. If you're drawn to it anyway, talk with your dentist or pharmacist first.

Avoid it entirely if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bloodroot, straight from the product label.

Brand Herb Stop
Net contents 1 Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Aug 24, 2023
DSLD ID 297165
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bloodroot by Herb Stop, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
30 Drop(s)
Maximum serving Sizes:
30 Drop(s)
IngredientAmount% DV
Bloodroot Extract0 NP--

Other ingredients: Grape Alcohol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Use only as directed.

Precautions

Safety Guideline: May cause nausea and vomiting. Do not exceed recommended dosage. Discontinue use if any unusual symptoms occur. Use only as directed on label.

Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.

Keep away from children.

Brand IP Statement(s)

Herb Stop Health In Your Own Hands

Formula

Liquid Herbal Extract

Formulation

Certified Organic

Supports healthy cellular function

Certified Organic

Vegan & Cruelty-free

Vegan & Cruelty-free Made In The U.S.A.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bloodroot by Herb Stop label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bloodroot label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bloodroot by Herb Stop

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size30 Drop(s) Dosage formLiquid Amounts shown are per serving.

Bloodroot Extract

No known
interactions
0 NP per serving Form: Sanguinaria canadensis

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, bu...

Bloodroot Extract monograph & interactions

Other (inactive) ingredients: Grape Alcohol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bloodroot by Herb Stop Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Bloodroot. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Bloodroot, from the product label.

Herb Stop

See all Herb Stop products
Name
The Herb Stop
Street Address
PO Box 673
City
Pine
State
AZ
ZipCode
85544
Phone Number
877.345.4372
Web Address
www.herbstop.com
Pharmacist Counseling Corner

Bloodroot by Herb Stop: Common Questions

Does Bloodroot by Herb Stop interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Bloodroot. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Bloodroot contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant?
No. Bloodroot is likely unsafe during pregnancy because it may be toxic and its safety is not established. If you're pregnant or planning to be, avoid this product and talk with your doctor or pharmacist about safe dental health options.
Is it safe while breastfeeding?
No. Bloodroot should be avoided while breastfeeding due to a lack of safety data and potential toxicity. If you're nursing and need oral health support, ask your doctor or pharmacist for safer alternatives.
What side effects should I watch for?
Short-term oral use may cause nausea, vomiting, and drowsiness. Long-term use of bloodroot toothpaste or mouthwash can cause mouth sores, taste changes, and tooth staining. If you apply it to skin, expect severe irritation, burning, and scarring. Stop and seek medical attention if you experience any of these.
Does bloodroot actually work for gum disease?
Bloodroot is possibly effective for dental plaque and gingivitis, but the evidence is limited. For periodontitis, there isn't reliable evidence to say either way. Your dentist can recommend proven treatments that are much safer.
Why do you recommend against this product?
Bloodroot is potentially toxic and corrosive. The risks — including severe burns if applied to skin, dangerous low blood pressure and shock at high oral doses, and mouth damage with long-term use — far outweigh the modest evidence for its benefits. Safer options exist for dental health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bloodroot is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bloodroot label
Go deeper

The Full Monographs Behind Bloodroot’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bloodroot

Bloodroot is a North American plant whose red root sap contains potent alkaloids that are corrosive to skin and tissue. It has a long folk history, but there is no good evidence it safely tr...

Read the full Bloodroot monograph →
Sources

Sources & How We Checked

Bloodroot's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bloodroot 17 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Tenenbaum, H., Dahan, M., and Soell, M. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol. 1999;70(3):307-311. PubMed
  6. Eversole, L. R., Eversole, G. M., and Kopcik, J. Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 2000;89(4):455-464. PubMed
  7. Allen, C. L., Loudon, J., and Mascarenhas, A. K. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen.Dent. 2001;49(6):608-614.
  8. Kopczyk, R. A., Abrams, H., Brown, A. T., Matheny, J. L., and Kaplan, A. L. Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 months of use. J.Periodontol. 1991;62(10):617-622. PubMed
  9. Harper, D. S., Mueller, L. J., Fine, J. B., Gordon, J., and Laster, L. L. Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. J.Periodontol. 1990;61(6):352-358. PubMed
  10. Kuftinec, M. M., Mueller-Joseph, L. J., and Kopczyk, R. A. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. J.Can.Dent.Assoc. 1990;56(7 Suppl):31-33.
  11. Frankos, V. H., Brusick, D. J., Johnson, E. M., Maibach, H. I., Munro, I., Squire, R. A., and Weil, C. S. Safety of Sanguinaria extract as used in commercial toothpaste and oral rinse products. J.Can.Dent.Assoc. 1990;56(7 Suppl):41-47.
  12. Cullinan, M. P., Powell, R. N., Faddy, M. J., and Seymour, G. J. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Aust.Dent.J. 1997;42(1):47-51. PubMed
  13. Affleck, A. G. and Varma, S. A case of do-it-yourself Mohs' surgery using bloodroot obtained from the internet. Br.J Dermatol 2007;157(5):1078-1079. PubMed
  14. Cienki JJ, Zaret L. An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med. 2010;16(10):1125-7. PubMed
  15. Hou JL, Brewer JD. Black salve and bloodroot extract in dermatologic conditions. Cutis. 2015;95(6):309-11.
  16. Schilling LM, Saedi N. Bloodroot paste: what dermatologists and patients need to know. Dermatol Surg 2016;42(10):1223-4. PubMed
  17. Schlichte MJ, Downing CP, Ramirez-Fort M, Gordon R, Tyring S. Bloodroot associated eschar. Dermatol Online J 2014;20(7). DOI

See these in context on the Bloodroot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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