Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Bottoms Up Capsules Ingredients & Drug Interactions

by Wise Woman Herbals

Bottoms Up Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bottoms Up Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bottoms Up Capsules is a dietary supplement by Wise Woman Herbals with 7 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,223 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger Root Extract, Powder, Cinnamon Bark Extract, Powder, Butcher's Broom Root Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bottoms Up Capsules by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Bottoms Up Capsules by Wise Woman Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bottoms Up Capsules by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Powdered Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,080 mg) without saying how much of each component you get.

Bottoms Up Capsules contains seven ingredients. The main actives are cinnamon bark extract, stoneroot root extract, butcher's broom root extract, witch hazel powder, yarrow flower and leaf extract, horse chestnut powder, and ginger root extract.

These are combined in a proprietary blend (meaning the exact amounts of some ingredients aren't listed separately), plus rice husk and capsule material as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hemorrhoids — rated "Possibly Effective" (Witch Hazel) (Natural Medicines).
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Butcher's Broom) (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Ginger) (Natural Medicines).
  • On file: Pregnancy-induced nausea and vomiting — rated "Possibly Effective" (Ginger) (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Ginger) (Natural Medicines).

The evidence for these ingredients is limited. Cinnamon bark is rated insufficient evidence for all its studied uses—amenorrhea, angina, common cold, diabetes, diarrhea, and dyslipidemia—so we can't say it works for any of them.

Butcher's broom is possibly effective for chronic venous insufficiency (that swelling and heaviness in your legs from poor circulation), but has insufficient evidence for hemorrhoids, diabetic retinopathy, orthostatic hypotension, and lymphedema. Witch hazel is possibly effective for hemorrhoids but possibly ineffective for eczema.

Yarrow's effectiveness is insufficiently established for all its rated uses. Horse chestnut is possibly effective for chronic venous insufficiency as well, but insufficient evidence exists for hemorrhoids, irritable bowel syndrome, and kidney stones.

Ginger is possibly effective for pregnancy-induced nausea and dysmenorrhea (period pain) and osteoarthritis, but possibly ineffective for exercise-induced muscle soreness and chemotherapy-induced nausea.

The evidence, ingredient by ingredient Cassia Cinnamon Butcher's Broom Witch Hazel Yarrow Horse Chestnut Ginger

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cinnamon bark is likely safe in food amounts during pregnancy and lactation, though high-dose supplements should be avoided due to coumarin—a compound that can harm your liver over time in large quantities. Rare adverse effects include a rash or low blood sugar episodes; one person reported a rash at 1 gram daily, and one person on 1 gram daily for three months had a hypoglycemic seizure (though causation is unclear).

Butcher's broom is generally well tolerated short-term but not established for pregnancy or breastfeeding. Most common side effects are digestive: diarrhea, indigestion, heartburn, nausea, and vomiting.

One person hospitalized with severe vomiting and diarrhea after five days of use developed dangerous electrolyte imbalances. Witch hazel is topical-use only (not meant to be swallowed), with limited oral safety data.

Yarrow should be avoided in pregnancy (traditionally used to affect the uterus) and breastfeeding; topical use can cause allergic skin reactions, and handling the flowers has triggered asthma in at least one person. Horse chestnut is unsafe in pregnancy and has not been established for breastfeeding; raw plant parts are toxic, though processed seed extract (with the toxic esculin removed) is usually tolerated.

One case of serious heart inflammation was reported after heavy consumption. Ginger is generally well tolerated at typical doses but increases side effects at 5 grams per day or higher; common effects are nausea, belching, heartburn, diarrhea, and mouth irritation.

One person in a trial experienced mild arrhythmia.

Side effects, ingredient by ingredient Cassia Cinnamon Butcher's Broom Witch Hazel Yarrow Horse Chestnut Ginger

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Yarrow, Butcher's Broom, Ginger, Cassia Cinnamon, Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,224 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check your medications against these drug types: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel, phenprocoumon, and others)—both horse chestnut and ginger carry Moderate risk of increased bleeding. Diabetes medications (metformin, insulin, sulfonylureas, etc.)—both cinnamon and ginger may lower blood sugar and increase the risk of low blood sugar.

Heart or blood pressure medications, especially nifedipine, losartan, and alpha-adrenergic drugs like doxazosin—ginger and butcher's broom may interact. Lithium—yarrow may increase its levels.

Medications metabolized by your liver's CYP3A4 system or P-glycoprotein transporters (a very broad group including many cancer drugs, statins, and immunosuppressants)—ginger may alter their levels. Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with some evidence for venous circulation and digestive comfort, though the supporting data is often thin. If you take blood thinners, diabetes medications, lithium, heart medications, or drugs processed by your liver, you need to check each of your prescriptions against our medication checker before starting.

Pregnant people should avoid yarrow and horse chestnut entirely and talk with their doctor about cinnamon and ginger. Because witch hazel is in here and it's meant for topical use, and because several ingredients carry rare but serious adverse effects, run this by your pharmacist if you have liver concerns, blood clotting disorders, or take multiple medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bottoms Up Capsules, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840004344
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 335586
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bottoms Up Capsules by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
748840004344
IngredientAmount% DV
Cinnamon Bark Extract, Powder0 NP--
Powdered Proprietary Blend1080 mg--
Stoneroot Root Extract, Powder0 NP--
Butcher's Broom Root Extract, Powder0 NP--
Witch Hazel, Powder0 NP--
Yarrow Flower, Leaf Extract, Powder0 NP--
Horse Chestnut, Powder0 NP--
Ginger Root Extract, Powder0 NP--

Other ingredients: Capsule, Rice Husk

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules, 3 times per day.

Storage

Store in a cool, dry area away from direct sunlight with lid tightly sealed.

Precautions

Caution: Keep out of the reach of children.

Warning: Cancer and reproductive harm. www.p65warnings.ca.gov

General Statements

Botanical formula

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bottoms Up Capsules by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bottoms Up Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bottoms Up Capsules by Wise Woman Herbals

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Powdered Proprietary Blend

1080 mg per serving

Other (inactive) ingredients: Capsule, Rice Husk. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bottoms Up Capsules by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Bottoms Up Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,223Drugs
1,143 Moderate 80 Minor

Ingredients driving the most interactions

Ginger Root Extract, Powder 1,007
Cinnamon Bark Extract, Powder 442
Butcher's Broom Root Extract, Powder 158
Horse Chestnut, Powder 122
Yarrow Flower, Leaf Extract, Powder 1

Individual Drug Interactions

The ingredients in Bottoms Up Capsules interact with 1,223 drugs. Click any drug to see the details.

5 of the 7 ingredients in Bottoms Up Capsules interact with drugs. Each result below shows which ingredient is responsible. Ginger Root Extract, Powder Cinnamon Bark Extract, Powder Butcher's Broom Root Extract, Powder Horse Chestnut, Powder Yarrow Flower, Leaf Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Bottoms Up Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginger Root Extract, Powder14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger Root Extract, Powder full monograph & interactions

Cinnamon Bark Extract, Powder2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon Bark Extract, Powder full monograph & interactions

Butcher's Broom Root Extract, Powder2 drug types · 158 drugs

Alpha-Adrenergic Agonists

Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Alpha-Adrenergic Antagonists

Theoretically, butcher's broom might reduce the effects of alpha-adrenergic antagonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Butcher's Broom Root Extract, Powder full monograph & interactions

Horse Chestnut, Powder1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut, Powder full monograph & interactions

Yarrow Flower, Leaf Extract, Powder1 drug type · 1 drug

Lithium

Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Yarrow Flower, Leaf Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bottoms Up Capsules, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
800.532.5219
Pharmacist Counseling Corner

Bottoms Up Capsules by Wise Woman Herbals: Common Questions

Does Bottoms Up Capsules by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Bottoms Up Capsules has a known interaction with 1,223 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bottoms Up Capsules contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No for yarrow and horse chestnut—the facts say to avoid both. For cinnamon and ginger, food amounts are likely safe, but talk with your doctor before taking supplements; ginger is sometimes used for morning sickness under medical supervision. We don't have pregnancy data on stoneroot, butcher's broom, or witch hazel, so check with your doctor first.
Can I take this while breastfeeding?
Avoid yarrow and horse chestnut—safety hasn't been established. Cinnamon is likely safe in food amounts. Ginger and butcher's broom have limited data, so use food amounts if any and ask your doctor. We don't have breastfeeding safety information for stoneroot and witch hazel.
What are the most common side effects?
Digestive issues are most frequent: nausea, heartburn, diarrhea, and abdominal discomfort—especially from ginger and butcher's broom. Skin rashes can occur with cinnamon, yarrow, or witch hazel in sensitive people. Most side effects are mild, but butcher's broom and ginger can cause more serious effects at higher doses.
Is ginger safe in this product?
Ginger is generally well tolerated at typical doses in most healthy adults. Side effects rise at 5 grams per day or higher. The biggest concern is if you take blood thinners, diabetes drugs, or heart medications—ginger interacts with those.
Does this product work for varicose veins or hemorrhoids?
Horse chestnut and butcher's broom are both possibly effective for chronic venous insufficiency (the swelling and heaviness in your legs from poor circulation), though the evidence is limited. For hemorrhoids specifically, only witch hazel is possibly effective; butcher's broom and horse chestnut don't have enough evidence.
Why does this product contain witch hazel if it's not meant to be swallowed?
The facts indicate witch hazel is included as a powder ingredient in the capsule, but the safety data emphasize it's meant for topical use. We don't have reliable data on its safety when taken by mouth in supplement form, so that's a question to raise with the manufacturer or your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bottoms Up Capsules label
Go deeper

The Full Monographs Behind Bottoms Up Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Butcher's Broom

Interacts with 158 drugs

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence suggests it may help reduce swelling and di...

Read the full Butcher's Broom monograph → Herb & supplement monograph

Witch Hazel

Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a topical product for short-term use, but...

Read the full Witch Hazel monograph → Herb & supplement monograph

Yarrow

Interacts with 1 drug

Yarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits are not well proven. It is generally used...

Read the full Yarrow monograph → Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph →
Sources

Sources & How We Checked

Bottoms Up Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
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Butcher's Broom 8 references
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Witch Hazel 7 references
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Yarrow 8 references
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Horse Chestnut 21 references
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Ginger 64 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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