Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Bovine Cartilage Plus Ingredients & Drug Interactions

by BodSmith

Bovine Cartilage Plus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bovine Cartilage Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bovine Cartilage Plus is a dietary supplement by BodSmith with 2 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bovine Cartilage Plus by BodSmith

Ask about any prescription or over-the-counter medication and we check it for interactions with Bovine Cartilage Plus by BodSmith — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bovine Cartilage Plus by BodSmith

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bovine Cartilage Plus contains 2 active ingredients. Papain is a protein-digesting enzyme derived from papaya that has been studied for various uses including exercise-related muscle soreness, herpes zoster (shingles), and radiation skin damage, though the evidence for these purposes remains insufficient.

Bovine tracheal cartilage is a structural tissue extract. The product also includes gelatin and leucine as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support connective tissue and joint functions.
  • We looked for evidence on: Exercise-induced muscle soreness, Wound healing, Joint health, Cartilage support, Connective tissue integrity.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence we hold rates papain as having insufficient reliable evidence to support its use for cancer, dental cavities, radiation dermatitis, exercise-induced muscle soreness, shingles, or intestinal parasites. No effectiveness ratings are on file for bovine tracheal cartilage.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as a food, though concentrated papain supplements may irritate the digestive tract and trigger allergic reactions in sensitive individuals — symptoms can include itchy eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. High oral doses may be unsafe and in rare cases have caused esophageal perforation and severe inflammation of the stomach lining.

People with papain sensitivity may also react to airborne papain dust with respiratory symptoms like congestion, wheezing, and cough. Safety data for papain in pregnancy advises against concentrated forms and unripe papaya products; there isn't enough data to know whether supplemental papain is safe during breastfeeding, so talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any other blood thinner, check with your pharmacist before starting — papain may increase how strongly blood thinners work. We cannot check bovine tracheal cartilage against your medications because we hold no interaction data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take warfarin or another blood thinner, don't start this product without checking with your pharmacist first — papain may strengthen the blood-thinning effect. If you have a known sensitivity to papain or papaya, this supplement isn't for you.

For anyone else, the main concern is potential digestive upset or allergic reaction.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bovine Cartilage Plus, straight from the product label.

Brand BodSmith
Barcode (UPC) 6029540268606
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 252203
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bovine Cartilage Plus by BodSmith, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
6029540268606
IngredientAmount% DV
Papain30 mg--
Bovine Tracheal Cartilage1000 mg--

Other ingredients: Gelatin, Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bovine Tracheal Cartilage is a natural source (165 mg oper capsule) of Chondroitin -4- and -6- Sulfates.

A source of Chondroitin -4- and -6- Sulfates

Formulation

Color of this product may vary due to color variations of the natural ingredients.

Made with Non GMO ingredients

Gluten free

Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

A Dietary Supplement to support connective tissue and joint functions

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 capsules with each meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bovine Cartilage Plus by BodSmith label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bovine Cartilage Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bovine Cartilage Plus by BodSmith

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
30 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bovine Tracheal Cartilage

1000 mg per serving

Other (inactive) ingredients: Gelatin, Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bovine Cartilage Plus by BodSmith Drug Interactions

Want to check YOUR meds against Bovine Cartilage Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Bovine Cartilage Plus interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Bovine Cartilage Plus interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Bovine Cartilage Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bovine Cartilage Plus, from the product label.

BodSmith

See all BodSmith products
Name
BodSmith
Street Address
P.O. Box 513
City
Litchfield
State
MI
ZipCode
49252
Web Address
www.bodsmith.com
Pharmacist Counseling Corner

Bovine Cartilage Plus by BodSmith: Common Questions

Does Bovine Cartilage Plus by BodSmith interact with any medications?
Yes. Based on its ingredients, Bovine Cartilage Plus has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bovine Cartilage Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papain safe if I'm pregnant or breastfeeding?
Concentrated papain and unripe papaya products are not advised during pregnancy due to safety concerns. There isn't enough reliable information on supplemental papain during breastfeeding, so you should talk with your doctor or pharmacist before taking this product if you're nursing.
Can papain cause an allergic reaction?
Yes. In people sensitive to papain, allergic reactions can include itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. If you have a known papaya or papain sensitivity, this supplement isn't a good choice for you.
What does papain do in this product?
Papain is a protein-digesting enzyme from papaya. The product lists it for several uses — exercise-related muscle soreness, shingles, radiation skin damage, cancer, dental cavities, and intestinal parasites — but the evidence for all of these purposes remains insufficient to rate.
Can high doses of papain cause serious problems?
Yes, though serious side effects are rare. Taking high oral doses may cause severe stomach inflammation or, in rare cases, esophageal perforation. Short-term use at appropriate doses is generally well tolerated.
What is bovine tracheal cartilage, and is it safe?
Bovine tracheal cartilage is a structural tissue extract from cattle. We don't hold safety or interaction data for this ingredient, so we can't comment on its safety profile beyond what papain carries.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bovine Cartilage Plus label
Go deeper

The Full Monographs Behind Bovine Cartilage Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Bovine Cartilage Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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