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Dietary supplement

Broccoli Active 500 mg Ingredients & Drug Interactions

by Bluebonnet

Broccoli Active 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Broccoli Active 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Broccoli Active 500 mg is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli whole plant extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Broccoli Active 500 mg by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with Broccoli Active 500 mg by Bluebonnet — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Broccoli Active 500 mg by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: broccoli whole plant extract at 500 mg per capsule. The capsule itself is made from hypromellose (a plant-based coating), with purified water, cellulose, and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cellular protective benefits.
  • We looked for evidence on: Bladder cancer, Breast cancer, Colorectal cancer, Gastric cancer, Prostate cancer, oxidative stress — and 1 related terms.
  • The strongest evidence on file: Broccoli is rated "Possibly Effective" for Colorectal cancer (Natural Medicines).
  • Also on file: Broccoli is rated "Insufficient Reliable Evidence To Rate" for Bladder cancer, Breast cancer, Gastric cancer, Prostate cancer.

Broccoli extract is possibly effective for colorectal cancer prevention based on available evidence. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the evidence is insufficient to rate — the research either isn't there or isn't reliable enough yet to say whether it works.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is well tolerated by most people, but concentrated supplements like this one are less studied. The safety notes in our data advise caution with concentrated extracts unless your doctor approves.

Some people taking broccoli seed and sprout extracts have reported loose stools, diarrhea, belly pain, and cramping, especially at higher doses. There's also a rare report of allergic skin reactions (contact dermatitis) from direct broccoli contact.

During pregnancy and lactation, broccoli is rated likely safe, though that rating applies to broccoli as food — talk with your doctor or pharmacist about whether a concentrated supplement fits your situation.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Broccoli Active, check with your pharmacist or doctor if you take any drugs metabolized by CYP1A2 or CYP2A6 — broccoli can speed up how your liver breaks these medications down, potentially lowering their effectiveness. These are common liver enzymes, so the interaction applies to a broad range of drugs.

Use the medication search tool on this page to verify your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in broccoli extract for colorectal cancer prevention and don't take any liver-processed medications, this could be worth a conversation with your doctor or pharmacist. If you do take prescription drugs — especially those broken down by your liver — you'll want to check your list against the interaction search below before starting.

Anyone who gets stomach upset easily should know that loose stools and cramping have been reported. Run this past your own healthcare provider before you add it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Broccoli Active 500 mg, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715012608
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 280029
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Broccoli Active 500 mg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
743715012608
IngredientAmount% DV
Broccoli whole plant extract500 mg--

Other ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bluebonnet's Broccoli Active 500 mg Vegetable Capsules are formulated with sulforaphane glucosinolates from the broccoli plant, sprouts and seeds, which provide powerful cellular protective benefits.

Bluebonnet's KOF-K Certification #K-0000700

K Parve (Kosher)

Formulation

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of corn, gluten, barley, rice, sodium and sugar.

Cellular Protection

Vegan

Gluten free

Brand IP Statement(s)

BroccoliActive is a registered trademark of Bluebonnet Nutrition Corporation.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made with NON GMO ingredients

K Parve (Kosher)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily, preferably with a meal or as directed by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Broccoli Active 500 mg by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Broccoli Active 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Broccoli Active 500 mg by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Broccoli whole plant extract

Interacts with
187 drugs
500 mg per serving Form: Sulforaphane Glucosinolates

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli whole plant extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Broccoli Active 500 mg by Bluebonnet Drug Interactions

Want to check YOUR meds against Broccoli Active 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Broccoli whole plant extract 187

Individual Drug Interactions

The ingredients in Broccoli Active 500 mg interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Broccoli Active 500 mg interact with drugs. Each result below shows which ingredient is responsible. Broccoli whole plant extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Broccoli Active 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli whole plant extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli whole plant extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Broccoli Active 500 mg, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Broccoli Active 500 mg by Bluebonnet: Common Questions

Does Broccoli Active 500 mg by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Broccoli Active 500 mg has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Broccoli Active 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this actually prevent cancer?
Broccoli extract is possibly effective for colorectal cancer based on current evidence. For other cancers like bladder, breast, and gastric, we don't have enough reliable research to say whether it helps. Talk to your doctor about whether it fits into your overall prevention plan.
What's in the capsule besides the broccoli extract?
The capsule itself is made from hypromellose, with purified water, cellulose, and magnesium stearate — all inactive ingredients that help hold the supplement together. There are no other active compounds.
Is it safe to take while pregnant or breastfeeding?
Broccoli as a food is rated likely safe during pregnancy and lactation. However, that rating is for broccoli you eat — the safety of concentrated extracts like this supplement isn't as well established. Talk with your doctor or pharmacist to decide whether this supplement is right for you during pregnancy or while nursing.
What side effects might I notice?
Some people who take broccoli seed and sprout extracts report loose stools, diarrhea, belly pain, and cramping, especially at higher doses. There's also a rare report of allergic skin reactions from direct broccoli contact. If your stomach is sensitive, start low and talk to your pharmacist if you have concerns.
Is this the same as eating broccoli?
No — this is a concentrated extract at 500 mg, and concentrated supplements are less studied than broccoli as food. While eating broccoli is well tolerated, we're less certain about the long-term safety of taking it as a concentrated supplement, so get your doctor's okay first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Broccoli Active 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Broccoli Active 500 mg label
Go deeper

The Full Monographs Behind Broccoli Active 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Broccoli Active 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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