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Dietary supplement

Calendula Ingredients & Drug Interactions

by Herbs Etc.

Calendula label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calendula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Calendula is a dietary supplement by Herbs Etc. with 1 active ingredient. Its ingredients are commonly taken for minor wounds and skin healing, skin inflammation and irritation, diaper rash.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are fresh Calendula. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calendula by Herbs Etc.

Ask about any prescription or over-the-counter medication and we check it for interactions with Calendula by Herbs Etc. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calendula by Herbs Etc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: fresh Calendula, a flowering herb traditionally used for skin health. The liquid form also includes 40% grain alcohol and purified water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calendula product and its label doesn't state a use — see Calendula's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that calendula relieves acne, bacterial vaginosis, burns, COPD symptoms, liver disease, or radiation dermatitis. The data shows insufficient reliable evidence to rate its usefulness for any of these conditions.

The evidence, ingredient by ingredient Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calendula is generally well tolerated when applied to the skin, but it can trigger allergic reactions in people sensitive to it — especially anyone allergic to ragweed, chrysanthemums, daisies, or other members of that plant family. Patch testing is recommended before use.

When taken by mouth, calendula may cause allergic reactions, and rarely, burning, itching, redness, or scaling have been reported with topical preparations. Safety data for oral use is limited, and the facts advise against taking it by mouth during pregnancy.

Side effects, ingredient by ingredient Calendula

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calendula.
  • The most serious interaction on file is rated Minor.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take CNS depressants — sedatives, sleep aids, anxiety or depression medications, or pain relievers that cause drowsiness — check your exact medications with the tool below before starting this product. The interaction is Minor, but worth confirming.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Calendula is a traditional skin herb that's generally well tolerated, but allergic reactions are possible — especially if you're sensitive to ragweed or related plants. The one documented drug interaction is minor and affects sedating medications.

Talk to your pharmacist if you're pregnant, nursing, or take any CNS depressants before using this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calendula, straight from the product label.

Brand Herbs Etc.
Net contents 8 Fluid Ounce(s); 236 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50194
Product type Botanical
Supplement form Liquid
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calendula by Herbs Etc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Ounce(s)
Maximum serving Sizes:
8 Ounce(s)
IngredientAmount% DV
fresh Calendula0 NP--

Other ingredients: 40% Grain Alcohol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Calendula officinalis

General

99034

General Statements

Herbal Single

Professional strength

Fresh flower extract

For dispensing purposes only

FDA Statement of Identity

Fast-acting dietary supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calendula by Herbs Etc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calendula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calendula by Herbs Etc.

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size8 Ounce(s) Dosage formLiquid Amounts shown are per serving.

Fresh Calendula

Interacts with
248 drugs
0 NP per serving

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing....

Fresh Calendula monograph & interactions

Other (inactive) ingredients: 40% Grain Alcohol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calendula by Herbs Etc. Drug Interactions

Want to check YOUR meds against Calendula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Minor

Ingredients driving the most interactions

fresh Calendula 248

Individual Drug Interactions

The ingredients in Calendula interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calendula interact with drugs. Each result below shows which ingredient is responsible. fresh Calendula

Each ingredient & the kinds of drugs it affects

For each ingredient in Calendula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Calendula1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
fresh Calendula full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calendula, from the product label.

Herbs Etc.

Name
Herbs, Etc.
Street Address
1340 Rufina Circle
City
Santa Fe
State
NM
ZipCode
87507
Web Address
www.herbsetc.com
Pharmacist Counseling Corner

Calendula by Herbs Etc.: Common Questions

Does Calendula by Herbs Etc. interact with any medications?
Yes. Based on its ingredients, Calendula has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calendula contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm allergic to ragweed?
No. Calendula is in the same plant family as ragweed, chrysanthemums, and daisies. If you have allergies to any of those, you're at higher risk for an allergic reaction to calendula. Patch testing on a small area of skin first is recommended to check for sensitivity.
Is it safe to take this while pregnant?
No. The safety data advises against taking calendula by mouth during pregnancy. Talk to your doctor or pharmacist about whether this product is right for you if you're pregnant or planning to become pregnant.
What side effects might I have?
Most people tolerate calendula well. Allergic reactions are the main concern — rashes, hives, or sensitivity reactions in people prone to allergies. When applied to skin, rarely, burning, itching, redness, or scaling have been reported. If you notice any of these, stop use and talk to a pharmacist.
Does this product really work for burns or acne?
The evidence we have is not strong enough to say whether calendula relieves burns, acne, or the other conditions listed on this page. The data shows insufficient reliable evidence to rate its effectiveness.
Why does this liquid contain alcohol?
This product is 40% grain alcohol, which is used as a solvent and preservative in herbal liquid extracts. If you need to avoid alcohol, talk to your pharmacist about whether this form is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calendula label
Go deeper

The Full Monographs Behind Calendula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph →
Sources

Sources & How We Checked

Calendula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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