Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

CalmEZ Brain Tonic Ingredients & Drug Interactions

by Allergy Research Group

CalmEZ Brain Tonic label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CalmEZ Brain Tonic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CalmEZ Brain Tonic is a dietary supplement by Allergy Research Group with 3 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and stress, digestive support.Based on those ingredients, 469 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Jujube (Ziziphus mauritianae) (seed) extract, Silk Tree (Albizia julibrissin) (bark) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CalmEZ Brain Tonic by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with CalmEZ Brain Tonic by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CalmEZ Brain Tonic by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.80 Gram(s)) without saying how much of each component you get.

CalmEZ Brain Tonic has 3 active ingredients: a proprietary blend that includes Ramulus uncariae (hook) extract, Jujube (Ziziphus mauritianae) seed extract, and Silk Tree (Albizia julibrissin) bark extract. Each is a plant extract traditionally used in herbal and traditional medicine formulas.

The product also contains inactive ingredients — hydroxypropyl methylcellulose, microcrystalline cellulose, and L-leucine — which serve as capsule material and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: calming and sleep support.
  • We looked for evidence on: Anxiety, Insomnia, Stress, Relaxation, Sleep quality, Nervousness.
  • The closest evidence on file: Zizyphus is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Zizyphus is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence we hold for Jujube covers six different uses — aging skin, anemia of chronic disease, anxiety, asthma, and athletic performance — and all carry a rating of insufficient reliable evidence. That means the science behind these claims isn't established enough for us to recommend the ingredient for any of them.

We have no effectiveness data on file for Ramulus uncariae or Silk Tree, so we can't speak to what either contributes.

The evidence, ingredient by ingredient Zizyphus Albizia Julibrissin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jujube fruit is eaten as food widely, but concentrated supplements haven't been well studied. A small clinical trial found headache in a couple of people and mild diarrhea, dry mouth, and increased bowel movements in others — numbers were very small.

The safety notes advise caution with medicinal doses and recommend avoiding them while breastfeeding, since there isn't enough reliable information. Silk Tree bark extract has limited human safety data.

The safety information advises against it in pregnancy and says avoid it while breastfeeding because there's no reliable data. We have no adverse effect reports on file for this ingredient.

Side effects, ingredient by ingredient Zizyphus Albizia Julibrissin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Zizyphus, Albizia Julibrissin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 469 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CalmEZ, double-check your medications if you take CNS depressants like sleep aids or anxiety medications — the Jujube and Silk Tree components may enhance their effects. Also check if you take diabetes medications (Jujube theoretically raises low blood sugar risk), CYP1A2-metabolized drugs like certain antidepressants, or anything processed heavily by your liver.

We couldn't check Ramulus uncariae, so run your full medication list through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

CalmEZ Brain Tonic may be worth considering if you're exploring traditional herbal support — but it's not for everyone. If you take sedatives, diabetes medications, or any prescription that your liver processes heavily, check with your pharmacist first.

Same goes for pregnancy and breastfeeding: the safety data says no for two of the three active ingredients we could check. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CalmEZ Brain Tonic, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947751606
Net contents 150 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233534
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CalmEZ Brain Tonic by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
50
UPC/BARCODE
713947751606
IngredientAmount% DV
Proprietary Blend1.8 Gram(s)--
Ramulus uncariae (hook) extract0 NP--
Jujube (Ziziphus mauritianae) (seed) extract0 NP--
Silk Tree (Albizia julibrissin) (bark) extract0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

CalmEZ Brain Tonic is a proprietary blend of Chinese herbs, including Collective Happiness Bark.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, for calming: 1 to 3 capsules two times daily; for sleep: 2 to 6 capsules before sleep, or as directed by a healthcare practitioner.

Precautions

Caution: May cause drowsiness, and should not be taken while operating a motor vehicle or other machinery.

Warning: Consuming this product can expose you to lead which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food

Storage

Keep in a cool, dry place, tightly capped.

FDA Statement of Identity

Dietary Supplement

Formulation

Hypoallergenic

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CalmEZ Brain Tonic by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CalmEZ Brain Tonic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CalmEZ Brain Tonic by Allergy Research Group

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1.8 Gram(s) per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

CalmEZ Brain Tonic by Allergy Research Group Drug Interactions

Want to check YOUR meds against CalmEZ Brain Tonic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
469Drugs
469 Moderate

Ingredients driving the most interactions

Jujube (Ziziphus mauritianae) (seed) extract 469
Silk Tree (Albizia julibrissin) (bark) extract 248

Individual Drug Interactions

The ingredients in CalmEZ Brain Tonic interact with 469 drugs. Click any drug to see the details.

2 of the 3 ingredients in CalmEZ Brain Tonic interact with drugs. Each result below shows which ingredient is responsible. Jujube (Ziziphus mauritianae) (seed) extract Silk Tree (Albizia julibrissin) (bark) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in CalmEZ Brain Tonic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Jujube (Ziziphus mauritianae) (seed) extract3 drug types · 469 drugs

Antidiabetes Drugs

Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that zizyphus has hypoglycemic activity. However, a small clinical study shows that zizyphus fruit powder does not reduce fasting blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Some animal research has found that various parts of zizyphus have sedative effects. However, other animal research shows that zizyphus plant extract does not alter sleep parameters when used in combination with pentobarbital.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Animal research shows that zizyphus induces CYP1A2 enzymes. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Jujube (Ziziphus mauritianae) (seed) extract full monograph & interactions

Silk Tree (Albizia julibrissin) (bark) extract1 drug type · 248 drugs

Cns Depressants

Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice. Theoretically, Albizia julibrissin might enhance the therapeutic and adverse effects of CNS depressants.
Some CNS depressants include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonopin), lorazepam (Ativan), zolpidem (Ambien), and others.

Likelihood Possible Evidence D
Silk Tree (Albizia julibrissin) (bark) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CalmEZ Brain Tonic, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
Alameda
State
CA
ZipCode
94502
Phone Number
510-263-2000
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

CalmEZ Brain Tonic by Allergy Research Group: Common Questions

Does CalmEZ Brain Tonic by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, CalmEZ Brain Tonic has a known interaction with 469 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CalmEZ Brain Tonic contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take CalmEZ if I'm pregnant or breastfeeding?
Jujube is rated likely safe in pregnancy and lactation. But Silk Tree is traditionally avoided in pregnancy and has no reliable safety data while breastfeeding — the facts say to avoid it. We have no pregnancy/lactation data for Ramulus uncariae. Talk with your doctor or pharmacist for personalized advice before taking this product.
What does Jujube seed extract actually do?
We hold effectiveness ratings for Jujube covering six uses — aging skin, anemia, anxiety, asthma, and athletic performance — but all are rated insufficient reliable evidence. The science isn't established enough to say it works for any of them.
Are there any side effects I should know about?
Jujube seed extract was associated with headache in a small trial. Jujube fruit extract caused mild diarrhea in infants, and seed extract caused dry mouth and increased bowel movements in small numbers. We have no adverse effect reports for the other ingredients.
What is Silk Tree bark extract supposed to help with?
The product facts don't list any effectiveness claims or ratings for Silk Tree, so I can't tell you what it's meant to do from the data we hold.
Is this product safe to take with my sleep medication?
CalmEZ contains Jujube and Silk Tree, both of which may enhance the sedative effects of sleep medications and other CNS depressants. That could make you drowsier or impair coordination. Check with your pharmacist before combining it with any sleep aid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CalmEZ Brain Tonic label
Go deeper

The Full Monographs Behind CalmEZ Brain Tonic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zizyphus

Interacts with 469 drugs

Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion. The fruit is a nutritious food, but human evidence for its medicinal benefits is li...

Read the full Zizyphus monograph → Herb & supplement monograph

Albizia Julibrissin

Interacts with 248 drugs

Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming the mind, lifting mood, and easing sleep problems. H...

Read the full Albizia Julibrissin monograph →
Sources

Sources & How We Checked

CalmEZ Brain Tonic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zizyphus 15 references
  1. Adzu, B., Amos, S., Dzarma, S., Wambebe, C., and Gamaniel, K. Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice. J Ethnopharmacol. 2002;79(1):13-16.
  2. Cisse, A., Ndiaye, A., Lopez-Sall, P., Seck, F., Faye, B., and Faye, B. [Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)]. Dakar Med 2000;45(2):105-107.
  3. Abdel-Zaher, A. O., Salim, S. Y., Assaf, M. H., and Abdel-Hady, R. H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol. 10-3-2005;101(1-3):129-138. PubMed
  4. Nesseem, D. I., Michel, C. G., Sleem, A. A., and El-Alfy, T. S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie 2009;64(2):104-109. DOI
  5. Anand, K. K., Singh, B., Chand, D., Chandan, B. K., and Gupta, V. N. Effect of Zizyphus sativa leaves on blood glucose levels in normal and alloxan-diabetic rats. J Ethnopharmacol. 1989;27(1-2):121-127. PubMed
  6. Morishita, S., Mishima, Y., Hirai, Y., Saito, T., and Shoji, M. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen Pharmacol 1987;18(6):637-641. PubMed
  7. Watanabe, I., Saito, H., and Takagi, K. Pharmacological studies of Zizyphus seeds. Jpn J Pharmacol 1973;23(4):563-571. DOI
  8. Wu, S. X., Zhang, J. X., Xu, T., Li, L. F., Zhao, S. Y., and Lan, M. Y. [Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function]. Zhongguo Zhong Yao Za Zhi 1993;18(11):685-4.
  9. Glombitza, K. W., Mahran, G. H., Mirhom, Y. W., Michel, K. G., and Motawi, T. K. Hypoglycemic and antihyperglycemic effects of Zizyphus spina-christi in rats. Planta Med 1994;60(3):244-247.
  10. Jarald, E. E., Joshi, S. B., and Jain, D. C. Antidiabetic activity of extracts and fraction of <it>Zizyphus mauritiana. Pharmaceutical Biology 2009;47:328-334.
  11. Ebrahimimd S, Ashkani-Esfahani S, Poormahmudibs A. Investigating the efficacy of zizyphus jujuba on neonatal jaundice. Iran J Pediatr. 2011 Sep;21(3):320-4.
  12. Hajhashemi V, Safaei A. Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice. Res Pharm Sci. 2015 Nov-Dec;10(6):477-84.
  13. Jing XY, Peng YR, Wang XM, Duan JA. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015 Aug;13(8):588-94. PubMed
  14. Irannejad Niri Z, Shidfar F, Jabbari M, et al. The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. J Food Biochem 2020; Mar 30
  15. Shergis JL, Hyde A, Meaklim H, Varma P, Da Costa C, Jackson ML. Medicinal seeds Ziziphus spinosa for insomnia: a randomized, placebo-controlled, cross-over, feasibility clinical trial. Complement Ther Med 2021;57:102657. PubMed

See these in context on the Zizyphus monograph →

Albizia Julibrissin 1 reference
  1. Kang, T. H., Jeong, S. J., Kim, N. Y., Higuchi, R., and Kim, Y. C. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000;71(1-2):321-323. PubMed

See these in context on the Albizia Julibrissin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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