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Dietary supplement

Cand-E-Cleanse Ingredients & Drug Interactions

by Herbally Grounded

Cand-E-Cleanse label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cand-E-Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cand-E-Cleanse is a dietary supplement by Herbally Grounded with 4 active ingredients. Its ingredients are commonly taken for mouth and gum irritation, sore throat, minor wound and skin care.Based on those ingredients, 552 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaparral, Pau d'Arco, Myrrh Gum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cand-E-Cleanse by Herbally Grounded

Ask about any prescription or over-the-counter medication and we check it for interactions with Cand-E-Cleanse by Herbally Grounded — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cand-E-Cleanse by Herbally Grounded

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

Cand-E-Cleanse contains four active ingredients: myrrh gum, chaparral, olive, and pau d'arco — each selected for traditional cleansing purposes. The product also contains cellulose as an inactive ingredient (a capsule filler).

Myrrh and pau d'arco have been used historically in herbal practice, while olive is familiar from food. Chaparral is a desert plant extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support body's natural balance and wellness.
  • We looked for evidence on: Diarrhea, Dyspepsia, Gingivitis, Influenza, Intestinal parasite infection, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The closest evidence on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Influenza.
  • Also on file: Myrrh is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Gingivitis, Ulcerative colitis, Intestinal parasite infection, and more.

The evidence we hold doesn't support effectiveness claims for any condition this product might be marketed for. Myrrh shows insufficient evidence for back pain, cancer, colds, dental issues, and Crohn disease, and it's actually rated likely ineffective for schistosomiasis.

Olive, pau d'arco, and chaparral all show insufficient evidence or no established ratings for their traditional uses. This is an important gap — you should talk with your pharmacist or doctor about whether there's clinical support for what you're hoping this product will do.

The evidence, ingredient by ingredient Myrrh Chaparral Olive Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product carries real safety red flags. Chaparral has been linked to severe liver damage, including cirrhosis and liver failure requiring transplant in multiple reported cases — the safety data advises against it altogether.

Myrrh may cause diarrhea at higher doses and is traditionally thought to stimulate the uterus, so it should be avoided in pregnancy. Pau d'arco may cause anemia and bleeding risk at higher doses, and should be avoided in pregnancy and while breastfeeding.

Olive is generally well tolerated in food amounts, but the safety of concentrated supplements hasn't been well studied. One person in a trial reported skin problems after taking olive leaf extract.

Side effects, ingredient by ingredient Myrrh Chaparral Olive Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Myrrh, Pau D'arco, Chaparral.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 553 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this if you take any drug that affects the liver, blood thinners like warfarin or newer anticoagulants, antiplatelet drugs like aspirin, or diabetes medications. Chaparral's liver toxicity poses the most serious risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is not a product we'd recommend without serious caution. Chaparral carries unacceptable liver toxicity risk, and the other ingredients present real interaction and safety concerns.

If you're considering it, talk with your pharmacist first — especially if you take any blood thinners, diabetes medication, or drugs that affect the liver. Pregnant or breastfeeding?

Avoid it; the data advises against it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cand-E-Cleanse, straight from the product label.

Brand Herbally Grounded
Barcode (UPC) 718122288328
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318503
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cand-E-Cleanse by Herbally Grounded, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
718122288328
IngredientAmount% DV
Proprietary Blend2000 mg--
Myrrh Gum0 NP--
Chaparral0 NP--
Olive0 NP--
Pau d'Arco0 NP--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: Take 4 capsules twice a day for 2 weeks. If flu-like symptoms appear, reduce to 2 capsules a day until bottle is empty.

Formulation

The average modern diet is filled with highly refined carbohydrates, chemicals, processed foods, and pesticides that can upset the body's natural harmony. Cand-E-Cleanse has been formulated to support the body's natural balance of beneficial digestive flora and a healthy digestive system.

Vegetarian

Our herbs are always: Optimally organic or ethically wild-crafted when available

100% Raw

No fillers or toxic flowing agents

Never irradiated or fumigated

FDA Statement of Identity

Herbal Supplement

Precautions

Seek advice from a health care practitioner before use and, in so doing, inform them if you have had, or may have liver disease, frequently use alcoholic beverages, or are using any medications. Rare reports of serious liver disease have been associated with ingestion of chaparral.

Discontinue use and see a doctor if vomiting, fever, fatigue, abdominal pain, loss of appetite, or jaundice (e.g., dark urine, pale stools, yellow discoloration of the eyes) should occur.

FDA Disclaimer Statement

The statements on this label have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Vegetarian

GMP Certified High-Quality Products

K Parve K-1604 (Kosher)

Formula

K Parve K-1604 (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cand-E-Cleanse by Herbally Grounded label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cand-E-Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cand-E-Cleanse by Herbally Grounded

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

2000 mg per serving

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cand-E-Cleanse by Herbally Grounded Drug Interactions

Want to check YOUR meds against Cand-E-Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
552Drugs
552 Moderate

Ingredients driving the most interactions

Chaparral 370
Pau d'Arco 122
Myrrh Gum 88

Individual Drug Interactions

The ingredients in Cand-E-Cleanse interact with 552 drugs. Click any drug to see the details.

3 of the 4 ingredients in Cand-E-Cleanse interact with drugs. Each result below shows which ingredient is responsible. Chaparral Pau d'Arco Myrrh Gum

Each ingredient & the kinds of drugs it affects

For each ingredient in Cand-E-Cleanse with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaparral1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Likelihood Possible Evidence D
Chaparral full monograph & interactions

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions

Myrrh Gum2 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research suggests that myrrh has hypoglycemic effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, myrrh might decrease the effectiveness of warfarin.
In one case, a patient who was previously stable on warfarin had a significant decline in international normalized ratio (INR) following consumption of an aqueous extract of myrrh.

Likelihood Possible Evidence D
Myrrh Gum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cand-E-Cleanse, from the product label.

Herbally Grounded

See all Herbally Grounded products
Name
Herbally Grounded
City
Las Vegas
State
NV
ZipCode
89102
Phone Number
1.866.676.1410
Web Address
www.herballygrounded.com
Pharmacist Counseling Corner

Cand-E-Cleanse by Herbally Grounded: Common Questions

Does Cand-E-Cleanse by Herbally Grounded interact with any medications?
Yes. Based on its ingredients, Cand-E-Cleanse has a known interaction with 552 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cand-E-Cleanse contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's chaparral, and why is it a concern?
Chaparral is a desert plant extract in this product. The safety data shows it's been linked to serious liver damage, including cases requiring liver transplant. It's marked as something to avoid altogether — the risks outweigh any possible benefit.
Can I take this while pregnant or breastfeeding?
No. Myrrh is thought to stimulate the uterus, chaparral carries toxicity concerns, and pau d'arco lacks safety data for pregnancy and breastfeeding. The safety information advises against all three during these times.
Will this product actually work for what it claims?
The evidence we have doesn't establish that any of its ingredients work reliably for their traditional uses. The data shows insufficient evidence across the board — so there's no solid clinical support for its effectiveness.
What side effects might I experience?
Myrrh may cause diarrhea at higher doses. Pau d'arco at high doses may cause anemia, bleeding risk, severe nausea, and vomiting. Olive is generally well tolerated, though one trial participant reported skin problems. Chaparral can cause liver damage with symptoms like jaundice, fatigue, dark urine, and abdominal pain.
Is this safe to take with my blood thinner?
No — not without checking with your pharmacist first. Both myrrh and pau d'arco may interfere with blood thinners or increase bleeding risk, and your doctor needs to know before you add this product.
What about with diabetes medication?
Myrrh in this product may raise your low blood sugar risk when combined with diabetes drugs. Talk to your pharmacist or doctor before starting it if you take any diabetes medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cand-E-Cleanse label
Go deeper

The Full Monographs Behind Cand-E-Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Myrrh

Interacts with 88 drugs

Myrrh is a fragrant gum resin from Commiphora trees that has long been used in mouthwashes, throat remedies, and skin care. Modern evidence for most of its uses is limited and comes mostly f...

Read the full Myrrh monograph → Herb & supplement monograph

Chaparral

Interacts with 370 drugs

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...

Read the full Chaparral monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Cand-E-Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Myrrh 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Al Faraj S. Antagonism of the anticoagulant effect of warfarin caused by the use of Commiphora molmol as a herbal medication: a case report. Ann Trop Med Parasitol 2005;99:219-20.
  6. Al-Jaroudi D, Kaddour O, Al-Amin N. Risks of myrrh use in pregnancy. JBRA Assist Reprod 2016;20(4):257-8.
  7. Xu YY, Li L, Xuan L, Guan K. Patch test diagnosis of non-immediate cutaneous reaction to myrrh following oral intake of a traditional Chinese medicine decoction. Contact Dermatitis. 2019;80(2):135-136. PubMed
  8. Al-Romaiyan A, Huang GC, Jones P, Persaud S. Commiphora myrrha stimulates insulin secretion from mouse and human islets of Langerhans. J Ethnopharmacol. 2021 Jan 10;264:113075. PubMed

See these in context on the Myrrh monograph →

Chaparral 16 references
  1. Smith BC, Desmond PV. Acute hepatitis induced by ingestion of the herbal medication chaparral. Aust N Z J Med 1993;23:526.. PubMed
  2. Gordon DW, Rosenthal G, Hart J, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995;273:489-90.
  3. Batchelor WB, Heathcote J, Wanless IR. Chaparral-induced hepatic injury. Am J Gastroenterol 1995;90:831-3.
  4. Katz M, Saibil F. Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6.
  5. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  6. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997;157:913-9. DOI
  7. Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7:175-85..
  8. Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep 1992;41:812-4.. DOI
  9. Estes JD, Stolpman D, Olyaei A, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg 2003;138:852-8.. PubMed
  10. Lambert JD, Zhao D, Meyers RO, et al. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40:1701-8.. PubMed
  11. Shasky DR. Contact dermatitis from Larrea tridentata (creosote bush). J Am Acad Dermatol 1986;15:302.. PubMed
  12. Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152:2089-91.. PubMed
  13. Kauma, H., Koskela, R., Makisalo, H., Autio-Harmainen, H., Lehtola, J., and Hockerstedt, K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand.J Gastroenterol. 2004;39(11):1168-1171. PubMed
  14. Leonforte, J. F. Contact dermatitis from Larrea (creosote bush). J Am Acad.Dermatol. 1986;14(2 Pt 1):202-207. PubMed
  15. Alderman, S., Kailas, S., Goldfarb, S., Singaram, C., and Malone, D. G. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin.Gastroenterol. 1994;19(3):242-247.
  16. Clark, F. Chaparral-induced toxic hepatitis: California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-814. DOI

See these in context on the Chaparral monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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