Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Carbo & Fat Killer Ingredients & Drug Interactions

by HBC Protocols

Carbo & Fat Killer label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Carbo & Fat Killer against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Carbo & Fat Killer is a dietary supplement by HBC Protocols with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 758 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggul extract, Chitosan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Carbo & Fat Killer by HBC Protocols

Ask about any prescription or over-the-counter medication and we check it for interactions with Carbo & Fat Killer by HBC Protocols — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Carbo & Fat Killer by HBC Protocols

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Carbo & Fat Killer contains 4 active ingredients. Guggul extract is a resin from a tree traditionally used in Ayurvedic medicine, thought to support cholesterol and weight management.

Chitosan is a fiber derived from shellfish shells, designed to bind dietary fats and support weight management. Phaseolamin 2250 is a starch-blocking compound (we hold no interaction data for it).

Coral calcium with selenium and trace minerals provides a calcium source with added micronutrients. The capsules also contain inactive ingredients—gymnema sylvestre, magnolia bark extract, gelatin, and magnesium stearate—which are fillers and binders that help form and stabilize the product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: carbohydrate and fat absorption reduction.
  • We looked for evidence on: Obesity, Hypercholesterolemia, Weight management, Metabolic health.
  • The strongest evidence on file: Chitosan is rated "Possibly Effective" for Obesity (Natural Medicines).
  • Also on file: Guggul is rated "Possibly Ineffective" for Obesity.
  • Also on file: Guggul is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia.

The evidence for this product is mixed and incomplete. Guggul extract is rated possibly ineffective for obesity and shows insufficient evidence for acne, hemorrhoids, and high cholesterol.

Chitosan is rated possibly effective for obesity and possibly effective for blood pressure and postoperative recovery, though evidence is limited for other uses like Crohn disease and dry eye. For coral calcium and trace minerals, we have effectiveness data only for bone grafting (rated likely effective), not for oral supplementation.

Phaseolamin 2250's effectiveness is not rated in our data.

The evidence, ingredient by ingredient Guggul Chitosan Coral

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guggul is generally well tolerated but can cause digestive upset—belching, bloating, diarrhea, headache, nausea, and unpleasant taste are the most common side effects. Skin reactions (rash, itching, swelling) occur in about 3% of people at lower doses and 15% at higher doses.

Rarely, rhabdomyolysis (muscle breakdown) has been reported. It is likely unsafe in pregnancy because it may stimulate the uterus, and there isn't enough safety data for breastfeeding.

Chitosan is well tolerated short-term but can cause constipation, diarrhea, gas, nausea, and throat dryness. Excessive fat in the stool (steatorrhea) has been reported.

Avoid during pregnancy and breastfeeding because safety data are insufficient. Note that chitosan is derived from shellfish, so it poses a risk if you have a shellfish allergy.

Side effects, ingredient by ingredient Guggul Chitosan Coral

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Guggul, Chitosan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 759 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Carbo & Fat Killer, double-check with your pharmacist if you take any heart or blood pressure medications (especially propranolol or diltiazem), blood thinners (warfarin or antiplatelet drugs), birth control pills, estrogen therapy, thyroid hormone, tamoxifen, or the antiviral acyclovir. Moderate interactions are documented for all of these with guggul and/or chitosan.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Consider Carbo & Fat Killer if you're exploring weight management support and don't take heart medications, blood thinners, birth control, thyroid hormone, cancer treatments, or antivirals like acyclovir—all of which may interact with guggul or chitosan. If you take any prescription or over-the-counter medication, check it against the interaction tool on this page or talk with your pharmacist before you start.

Pregnant or breastfeeding? Avoid this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Carbo & Fat Killer, straight from the product label.

Brand HBC Protocols
Barcode (UPC) 679840751603
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 247908
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Carbo & Fat Killer by HBC Protocols, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
679840751603
IngredientAmount% DV
Guggul extract45 mg--
Chitosan200 mg--
Phaseolamin 2250250 mg100%
Coral Calcium Selenium Trace Minerals200 mg100%

Other ingredients: Gymnema sylvestre, Magnolia Bark Extract, Gelatin Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No animal products are used in this product.

Contains no sugar, starch, yeast, artificial colors, preservatives or dairy products.

Carbo & Fat Killer with sugar neutralizers

Precautions

Keep out of the reach of children.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: Recent research has shown the optimum time to take Phase 2 is just before a starch-rich meal along with 8 oz. of water. However, the studies also showed that Phase 2 could still provide some of its starch "neutralizing" benefits when taken during, or just after, a starch-rich meal.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Phase 2

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Carbo & Fat Killer by HBC Protocols label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Carbo & Fat Killer label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Carbo & Fat Killer by HBC Protocols

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Guggul extract

Interacts with
757 drugs
45 mg per serving

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul extract monograph & interactions

Chitosan

Interacts with
3 drugs
200 mg per serving

Chitosan is a fiber-like substance made from the shells of shrimp, crabs, and other shellfish, often marketed for weight loss and cholesterol. The evi...

Chitosan monograph & interactions

Phaseolamin 2250

250 mg per serving

Coral Calcium Selenium Trace Minerals

No known
interactions
200 mg per serving

Coral calcium is a calcium supplement made from coral skeletons (often fossilized) that also contains small amounts of other minerals. It is essential...

Coral Calcium Selenium Trace Minerals monograph & interactions

Other (inactive) ingredients: Gymnema sylvestre, Magnolia Bark Extract, Gelatin Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Carbo & Fat Killer by HBC Protocols Drug Interactions

Want to check YOUR meds against Carbo & Fat Killer?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
758Drugs
758 Moderate

Ingredients driving the most interactions

Guggul extract 757
Chitosan 3

Individual Drug Interactions

The ingredients in Carbo & Fat Killer interact with 758 drugs. Click any drug to see the details.

2 of the 4 ingredients in Carbo & Fat Killer interact with drugs. Each result below shows which ingredient is responsible. Guggul extract Chitosan

Each ingredient & the kinds of drugs it affects

For each ingredient in Carbo & Fat Killer with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Guggul extract9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul extract full monograph & interactions

Chitosan2 drug types · 3 drugs

Acyclovir (Zovirax)

Chitosan can reduce the absorption of acyclovir, potentially increasing the risk for treatment failure.
Clinical research in humans shows that taking chitosan along with acyclovir 200 mg reduces acyclovir absorption. Concomitant administration of chitosan 400 mg or 1000 mg reduced the acyclovir area under the curve (AUC) and peak plasma concentration by about 30% and 40%, respectively, compared with control. Concomitant administration with chitosan 1000 mg also increased time to peak concentration from 1 hour to 2 hours. In vitro research suggests that the mechanism for reduced absorption is due to acyclovir entrapment in chitosan-mucus complexes, which reduces intestinal absorption.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, chitosan might increase the risk of bleeding when taken with warfarin.
In a case report, a patient taking warfarin had a significantly increased international normalized ratio (INR) after starting chitosan 1200 mg daily. The INR normalized after chitosan was discontinued and vitamin K was administered. The patient once again started taking chitosan and again had a significant increase in INR. The INR stabilized again once chitosan was discontinued. Researchers theorize that this interaction might occur because chitosan decreases absorption of fat-soluble vitamins, including vitamin K, which could increase the anticoagulant effect of warfarin.

Likelihood Possible Evidence D
Chitosan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Carbo & Fat Killer, from the product label.

HBC Protocols

See all HBC Protocols products
Name
hbc Protocols
Street Address
8205 Santa Monica Blvd. Suite 472
City
Los Angeles
State
CA
ZipCode
90046
Phone Number
888.497.3742
Web Address
www.hbcstore.com
Pharmacist Counseling Corner

Carbo & Fat Killer by HBC Protocols: Common Questions

Does Carbo & Fat Killer by HBC Protocols interact with any medications?
Yes. Based on its ingredients, Carbo & Fat Killer has a known interaction with 758 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Carbo & Fat Killer contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this affect my birth control?
Possibly. Guggul in this product acts like estrogen in your body, which theoretically could interfere with how birth control works and increase the risk of unwanted effects. Talk to your pharmacist or doctor before combining them.
What digestive side effects might I get?
Guggul can cause belching, bloating, diarrhea, nausea, and an unpleasant taste. Chitosan may cause constipation, gas, and nausea. Most people tolerate it short-term, but if these bother you, stop and tell your pharmacist.
Can I take this if I'm pregnant?
No. Guggul is likely unsafe in pregnancy because it may stimulate the uterus, and chitosan hasn't been studied enough to know it's safe. Avoid this product during pregnancy and breastfeeding.
Is this safe if I have a shellfish allergy?
No. Chitosan is derived from shellfish shells, so it poses an allergy risk. Choose a different product if you have a shellfish allergy.
Does guggul actually help with weight loss or cholesterol?
The evidence is weak. Guggul is rated possibly ineffective for obesity and shows insufficient evidence for high cholesterol. Chitosan is rated possibly effective for weight, but evidence remains limited overall.
What are the skin reactions people report with this?
Guggul can cause rash, itching, and swelling—often dose-dependent. At lower doses, about 3% of people had skin reactions; at higher doses, about 15% did. Severity ranged from mild itching to facial swelling.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Carbo & Fat Killer is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Carbo & Fat Killer label
Go deeper

The Full Monographs Behind Carbo & Fat Killer’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph → Herb & supplement monograph

Chitosan

Interacts with 3 drugs

Chitosan is a fiber-like substance made from the shells of shrimp, crabs, and other shellfish, often marketed for weight loss and cholesterol. The evidence for these benefits is weak, and an...

Read the full Chitosan monograph → Herb & supplement monograph

Coral

Coral calcium is a calcium supplement made from coral skeletons (often fossilized) that also contains small amounts of other minerals. It is essentially a form of calcium carbonate, and ther...

Read the full Coral monograph →
Sources

Sources & How We Checked

Carbo & Fat Killer's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Chitosan 17 references
  1. Jing SB, Li L, Ji D, et al. Effect of chitosan on renal function in patients with chronic renal failure. J Pharm Pharmacol 1997;49:721-3. PubMed
  2. Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr 1999;53:379-81. PubMed
  3. Ho SC, Tai ES, Eng PH, et al. In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects. Singapore Med J 2001;42:6-10.
  4. Bokura H, Kobayashi S. Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 2003;57:721-5. PubMed
  5. Mhurchu CN, Poppitt SD, McGill AT, et al. The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord 2004;28:1149-56. PubMed
  6. Huang SS, Sung SH, Chiang CE. Chitosan potentiation of warfarin effect. Ann Pharmacother 2007;41:1912-4. PubMed
  7. Tsai, G. J. and Su, W. H. Antibacterial activity of shrimp chitosan against Escherichia coli. J Food Prot. 1999;62(3):239-243. PubMed
  8. Wuolijoki, E., Hirvela, T., and Ylitalo, P. Decrease in serum LDL cholesterol with microcrystalline chitosan. Methods Find.Exp Clin Pharmacol. 1999;21(5):357-361. PubMed
  9. Nelson, J. L., Alexander, J. W., Gianotti, L., Chalk, C. L., and Pyles, T. Influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutrition 1994;10(1):32-36.
  10. Schiller RN, Barrager E, Schauss EA, and et al. A randomized, double-blind, placebo-controlled study examining the effects of a rapidly soluble chitosan dietary supplement on weight loss and body composition in overweight and mildly obese individuals. J
  11. Koide, S. S. Chitin-chitosan: properties, benefits and risks. Nutrition Research 1998;8(6):1091-1101. DOI
  12. Maezaki Y, Tsuji K, Nakawa, and et al. Hypocholesterolaemic effect of chitosan in adult males. Biosc Biochem Biotech 1993;57:1439-1444.
  13. Kubbinga M, Nguyen MA, Staubach P, et al. The influence of chitosan on the oral bioavailability of acyclovir-a comparative bioavailability study in humans. Pharm Res 2015;32(7):2241-9. PubMed
  14. Jull AB, Ni Mhurchu C, Bennett DA, et al. Chitosan for overweight or obesity. Cochrane Database Syst Rev 2008;(3):CD003892. PubMed
  15. Schmidl D, Werkmeister R, Kaya S, et al. A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. J Ocul Pharmacol Ther. 2017;33(5):375-382.
  16. Moraru C, Mincea MM, Frandes M, Timar B, Ostafe V. A meta-analysis on randomised controlled clinical trials evaluating the effect of the dietary supplement chitosan on weight loss, lipid parameters and blood pressure. Medicina (Kaunas). 2018;54(6):109. PubMed
  17. García MA, Hensler G, Al-Gousous J, Pielenhofer J, Wagner M, Lennernäs H, Langguth P. Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus. Drug Metab Pharmacokinet. 2023;49:100491. PubMed

See these in context on the Chitosan monograph →

Coral 5 references
  1. Schulz A, Hilgers RD, Niedermeier W. The effect of splinting of teeth in combination with reconstructive periodontal surgery in humans. Clin Oral Investig 2000;4:98-105.. PubMed
  2. Vuola J, Bohling T, Kinnunen J, et al. Natural coral as bone-defect-filling material. J Biomed Mater Res 2000;51:117-22.. DOI
  3. Thalgott JS, Klezl Z, Timlin M, Giuffre JM. Anterior lumbar interbody fusion with processed sea coral (coralline hydroxyapatite) as part of a circumferential fusion. Spine 2002;27:E518-25.. PubMed
  4. Marchac D, Sandor G. Use of coral granules in the craniofacial skeleton. J Craniofac Surg 1994;5:213-7. PubMed
  5. Roux FX, Brasnu D, Menard M, et al. Madreporic coral for cranial base reconstruction. 8 years experience. Acta Neurochir (Wien) 1995;133:201-205. PubMed

See these in context on the Coral monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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