Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Carbo Load Grape Flavor Ingredients & Drug Interactions

by Extreme Edge

Carbo Load Grape Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Carbo Load Grape Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Carbo Load Grape Flavor is a dietary supplement by Extreme Edge with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 815 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cinnamon bark extract, Alpha Lipoic Acid, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Carbo Load Grape Flavor by Extreme Edge

Ask about any prescription or over-the-counter medication and we check it for interactions with Carbo Load Grape Flavor by Extreme Edge — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Carbo Load Grape Flavor by Extreme Edge

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Extreme Glucose Refueling Stack” is listed as a grouped ingredient — the label gives one combined amount (38.20 Gram(s)) without saying how much of each component you get.
  • “GlucoShock Action Stack” is listed as a grouped ingredient — the label gives one combined amount (75.20 mg) without saying how much of each component you get.

Carbo Load Grape Flavor contains 6 active ingredients. Alpha-lipoic acid is a potent antioxidant used to support nerve health and blood sugar metabolism.

Sodium is an essential electrolyte that helps maintain fluid balance and nerve function. Chromium appears twice and plays a role in blood sugar regulation and insulin sensitivity.

Cinnamon bark extract is included for potential metabolic and glucose-related effects. The product also contains a Complex Carbohydrates & Long Chain Glucose Polymers blend and an Extreme Glucose Refueling Stack (whose component ingredients aren't listed individually in your facts) designed to fuel energy and carbohydrate delivery.

Inactive ingredients—the fillers and flavorings—include natural grape flavor, citric acid, potassium bicarbonate, stevia extract, and grape.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Muscle replenishing, refueling and endurance support.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle cramps, Exercise recovery, Glycogen repletion, Stamina.
  • The closest evidence on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Muscle strength (Natural Medicines).
  • Also on file: Chromium is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Muscle cramps.

Alpha-lipoic acid is possibly effective for diabetic nerve damage (neuropathy) and elevated cholesterol and fat levels (hyperlipidemia), and possibly effective for weight management. Chromium is likely effective for chromium deficiency and possibly effective for diabetes, though it appears possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Cinnamon bark extract has insufficient reliable evidence to rate its effectiveness for amenorrhea, angina, common cold, diabetes, diarrhea, or dyslipidemia. Sodium's effectiveness is likely for cystic fibrosis and possibly effective for kidney damage from amphotericin B, but it has insufficient evidence for heart failure and bipolar disorder.

The effectiveness of the carbohydrate and glucose polymer blends is not established in the data we hold.

The evidence, ingredient by ingredient Sodium Chromium Alpha-lipoic Acid Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and is best used under medical guidance. The most common side effects are headache, heartburn, nausea, and vomiting.

Rare cases of an autoimmune insulin syndrome have been reported. It is not recommended during pregnancy or while breastfeeding due to insufficient safety data.

Chromium is generally well tolerated at typical supplement doses, though high or long-term doses may pose risks. Common side effects include stomach irritation, headaches, insomnia, irritability, and mood changes.

Rare cases of kidney and liver damage and blood cell problems have been reported. Small dietary amounts are acceptable during pregnancy, but extra supplement doses should be avoided unless your doctor recommends it.

Sodium is essential in small amounts but can strain the heart and worsen high blood pressure and kidney disease when consumed in excess. Cinnamon bark extract is generally safe in food amounts; high-dose supplements may harm the liver over time and should be avoided during pregnancy.

A rash was reported in one trial participant taking 1 gram daily.

Side effects, ingredient by ingredient Sodium Chromium Alpha-lipoic Acid Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Chromium, Cassia Cinnamon, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 816 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check any antidiabetes drugs (including insulin)—chromium and cinnamon may lower blood sugar and raise hypoglycemia risk. Blood thinners and antiplatelet drugs (such as warfarin or aspirin) should be reviewed, as alpha-lipoic acid may increase bleeding.

Thyroid medications like levothyroxine need attention because both alpha-lipoic acid and chromium may reduce their absorption or effect. Chemotherapy drugs, corticosteroids (steroids), lithium, NSAIDs, and blood pressure medications also require checking before you use this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a carbohydrate and glucose formula with multiple active ingredients that affect blood sugar, thyroid function, and blood thinning. It's best for people managing energy and carbohydrate intake who don't take diabetes medications, thyroid drugs, blood thinners, or lithium.

Check your exact medications with the tool below before you start—especially if you take any drug for diabetes, thyroid problems, blood thinning, blood pressure, or mood disorders.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Carbo Load Grape Flavor, straight from the product label.

Brand Extreme Edge
Barcode (UPC) 743715018075
Net contents 1.55 oz.; 44 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 180035
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Carbo Load Grape Flavor by Extreme Edge, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
44 Gram(s)
Maximum serving Sizes:
44 Gram(s)
UPC/BARCODE
743715018075
IngredientAmount% DV
Calories150 Calorie(s)--
Total Carbohydrates38 Gram(s)13%
Sugar1 Gram(s)--
Alpha Lipoic Acid0 NP--
Sodium130 mg5%
Chromium200 mcg167%
Cinnamon bark extract0 NP--
Chromium0 NP--
Extreme Glucose Refueling Stack38.2 Gram(s)--
Complex Carbohydrates & Long Chain Glucose Polymers0 NP--
GlucoShock Action Stack75.2 mg--

Other ingredients: natural Grape flavor, Citric Acid, Potassium Bicarbonate, Stevia extract, Grape

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

2 Muscle replenishing & refueling stack

Sustains high energy & endurance Prolongs exercise tolerance Replenishes glucose levels instantly

Individual serving

instantized powder

This glucose replenishment formula spares liver and muscle glycogen for later use particularly during the recovery phase – with the right amounts and balance of performance-enhancing nutrients to help your body sustain unrivaled training intensity throughout the entire workout. Use it u once, and you’ll never train without it again!

Product tested for 200+ banned substances Product checked against sports prohibitive lists (NFL, MLB). More info at www.nsf.org

Other products from Extreme Edge: 1 Pre Workout Muscle recharging stack 3 Post Workout Muscle rebuilding & recovery stack + 100% Pure Whey Protein Isolate Rapid muscle rebuilder & amino acid replenisher

Formula

38 grams of complex carbs per serving

Extreme Edge Carb Load is a high octane formula delivering 38 grams of intense complex carbohydrates from waxy maize, plus long chain glucose polymers from maltodextrin, steel cut oats, brown rice and D-ribose, which are rapidly broken down into glucose, the body’s primary source of fuel.

Key features Provides 38 g of complex carbs for sustained energy & endurance

Professional strength for serious athletes

Seals/Symbols

Vegan

NSF Certified for sport

Formulation

Vegan

No banned substances detected

Free of artificially-derived colors, flavors and sweeteners No added sugar

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of yeast and barley.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, add one packet (44 g) to 16 fl oz of water, juice or sports drink and mix or shake until smooth. For best results, liquid should be very cold. Mixes instantly without the use of a blender. For Extreme results, take during workout.

General

1807C

Brand IP Statement(s)

Tested - Certified - Safer with NSF Certified for Sport

Extreme Edge is a registered trademark of Bluebonnet Nutrition Corp.

Precautions

Allergen Warning: Manufactured in a facility that processes products containing milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts and peanut flavor.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Carbo Load Grape Flavor by Extreme Edge label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Carbo Load Grape Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Carbo Load Grape Flavor by Extreme Edge

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size44 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Sodium

Interacts with
205 drugs
130 mg per serving Form: Sodium Bicarbonate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Amino Acid Chelate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Extreme Glucose Refueling Stack

38.2 Gram(s) per serving
  • › Complex Carbohydrates & Long Chain Glucose Polymers

GlucoShock Action Stack

75.2 mg per serving

Other (inactive) ingredients: Natural Grape flavor, Citric Acid, Potassium Bicarbonate, Stevia extract, Grape. These complete the product’s ingredient list but are not active constituents.

Interaction report

Carbo Load Grape Flavor by Extreme Edge Drug Interactions

Want to check YOUR meds against Carbo Load Grape Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
815Drugs
787 Moderate 28 Minor

Ingredients driving the most interactions

Cinnamon bark extract 442
Alpha Lipoic Acid 263
Sodium 205
Chromium 178

Individual Drug Interactions

The ingredients in Carbo Load Grape Flavor interact with 815 drugs. Click any drug to see the details.

4 of the 7 ingredients in Carbo Load Grape Flavor interact with drugs. Each result below shows which ingredient is responsible. Cinnamon bark extract Alpha Lipoic Acid Sodium Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Carbo Load Grape Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cinnamon bark extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon bark extract full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Carbo Load Grape Flavor, from the product label.

Extreme Edge

See all Extreme Edge products
Name
Bluebonnet Nutrition Corp.
Street Address
12915 Dairy Ashford
City
Sugar Land
State
Texas
ZipCode
77478
Web Address
www.ExtremeEdgeSports.com
Pharmacist Counseling Corner

Carbo Load Grape Flavor by Extreme Edge: Common Questions

Does Carbo Load Grape Flavor by Extreme Edge interact with any medications?
Yes. Based on its ingredients, Carbo Load Grape Flavor has a known interaction with 815 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Carbo Load Grape Flavor contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar?
Possibly. Alpha-lipoic acid, chromium, and cinnamon can all theoretically lower blood sugar. If you take diabetes medication or insulin, combining them could increase your low blood sugar (hypoglycemia) risk. Talk to your pharmacist or doctor before starting.
Can I take this if I'm on levothyroxine (Synthroid)?
Not without checking first. Chromium in this product can reduce levothyroxine absorption by about 17%, and alpha-lipoic acid may also interfere. If you take thyroid medication, run it through the checker on this page or ask your pharmacist before you add this product.
What are the side effects of alpha-lipoic acid?
The most common are headache, heartburn, nausea, and vomiting. Skin rash and itching have also been reported. Serious side effects are rare but can include an autoimmune insulin syndrome. Stop and call your doctor if you develop unusual symptoms.
Is this safe during pregnancy?
The safety data isn't there for alpha-lipoic acid or chromium during pregnancy, so it's best to avoid extra supplement doses unless your doctor advises it. Small amounts of chromium from food or prenatal vitamins are generally considered acceptable. Talk to your doctor for personalized advice.
Does the sodium in this raise blood pressure?
High sodium intake can increase blood pressure and reduce the effectiveness of blood pressure medications. The effect depends on how much sodium is in each serving and your overall intake. If you have high blood pressure or take medication for it, ask your pharmacist to review this product.
Why does chromium appear twice in the ingredient list?
Chromium is listed as a separate ingredient and also appears to be included in one of the branded blends (the Extreme Glucose Refueling Stack). The exact amounts aren't broken out, so your total chromium dose from this product isn't clear from the label alone. Ask the manufacturer if you need the exact amount.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Carbo Load Grape Flavor label
Go deeper

The Full Monographs Behind Carbo Load Grape Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph →
Sources

Sources & How We Checked

Carbo Load Grape Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 159 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
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Cassia Cinnamon 20 references
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  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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