Carda Lean Ingredients & Drug Interactions
by Brutal Force
What is this page for?
First and foremost: checking Carda Lean against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Carda Lean is a dietary supplement by Brutal Force with 6 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine Alpha-Ketoglutarate, Puncture Vine Extract, Ginseng Whole Plant Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Carda Lean by Brutal Force
Ask about any prescription or over-the-counter medication and we check it for interactions with Carda Lean by Brutal Force — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Carda Lean by Brutal Force
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Carda Lean has six active ingredients. L-Citrulline and L-Arginine Alpha-Ketoglutarate are amino acids that support blood vessel function and circulation.
Acetyl-L-Carnitine Hydrochloride helps your body produce energy and may support brain health. Ginseng Whole Plant Extract is an herbal ingredient used to support immune function and overall vitality.
Puncture Vine Extract (tribulus) is included for sexual function and athletic performance support. Wild Yam Powder rounds out the formula.
The capsules also contain inactive ingredients — hypromellose (the capsule shell), magnesium stearate, and silica.
Does it work?
Moderate evidence
L-Citrulline is possibly effective for athletic performance, though the evidence for heart health is not yet established. L-Arginine Alpha-Ketoglutarate's effectiveness is not rated in our data.
Acetyl-L-Carnitine Hydrochloride is possibly effective for age-related memory loss, Alzheimer disease, alcohol use disorder, diabetic nerve damage, and depression. Ginseng is possibly effective for upper respiratory infections; its effectiveness for other uses we hold data on is not established.
Puncture Vine Extract is possibly effective for sexual function but possibly ineffective for athletic performance. We hold no effectiveness data for Wild Yam Powder.
How safe is it?
Well-documented data
L-Citrulline is generally well tolerated, though long-term safety hasn't been fully studied; the most common side effects are gastrointestinal discomfort and heartburn. L-Arginine Alpha-Ketoglutarate is often well tolerated short-term but can lower blood pressure and should only be used under medical supervision.
Acetyl-L-Carnitine Hydrochloride is generally well tolerated short-term; side effects can include agitation, dry mouth, headache, and insomnia. Ginseng is generally well tolerated short-term in healthy adults, though quality and dosing vary.
Puncture Vine Extract is often well tolerated short-term, but rare serious side effects including liver and kidney injury and seizures have been reported. Regarding pregnancy and breastfeeding: L-Citrulline should be avoided in pregnancy and lactation due to insufficient safety data.
L-Arginine Alpha-Ketoglutarate is possibly safe in pregnancy but safety while breastfeeding is unknown — avoid during lactation. Acetyl-L-Carnitine Hydrochloride safety data are not on file for pregnancy and lactation — avoid in both unless your doctor advises otherwise.
Ginseng is possibly unsafe in pregnancy and should be avoided during breastfeeding. Puncture Vine Extract is possibly unsafe in pregnancy and should be avoided while breastfeeding.
Wild Yam Powder pregnancy and lactation data are not on file.
Meds to double-check
Major interaction found
Before taking Carda Lean, check with your pharmacist if you take warfarin or other blood thinners (anticoagulants) — ginseng can reduce their effectiveness (Major), and other ingredients may increase bleeding risk. Also double-check blood pressure medications, ACE inhibitors, ARBs, diabetes drugs, lithium, thyroid hormone, antidepressants or serotonergic drugs, immunosuppressants, and sildenafil (Viagra).
No interactions are documented for Wild Yam Powder in our data.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
Carda Lean is designed for athletic performance and circulation support, but its multiple active ingredients carry significant interactions with blood pressure drugs, blood thinners, diabetes medications, and other common prescriptions. If you take any regular medications — especially for heart health, blood clotting, or diabetes — talk with your pharmacist before starting this product.
The ingredient quality and long-term safety profile are not fully established.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Carda Lean, straight from the product label.
| Brand | Brutal Force |
|---|---|
| Barcode (UPC) | 753569239861 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 270701 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Carda Lean by Brutal Force, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 75 mg | -- |
| L-Arginine Alpha-Ketoglutarate | 150 mg | -- |
| Acetyl-L-Carnitine Hydrochloride | 75 mg | -- |
| Wild Yam, Powder | 750 mg | -- |
| Ginseng Whole Plant Extract | 375 mg | -- |
| Puncture Vine Extract | 37.5 mg | -- |
Other ingredients: Hypromellose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions for use: Adults, take 3 capsules approximately 20 minutes before your breakfast. Directions should be followed on both workout and non workout days.
Precautions
Caution: Do not exceed recommended dose.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.
Do not use if the packaging is open or looks tampered with.
Vitamin and dietary supplements are not intended to treat, diagnose or prevent any disease. Dietary supplements must not replace a balanced diet and healthy lifestyle.
Allergen warning: This product is manufactured in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and shellfish.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Carda Lean by Brutal Force label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Carda Lean by Brutal Force
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsL-Arginine Alpha-Ketoglutarate
Interacts with403 drugs
L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...
L-Arginine Alpha-Ketoglutarate monograph & interactionsAcetyl-L-Carnitine Hydrochloride
Interacts with203 drugs
Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...
Acetyl-L-Carnitine Hydrochloride monograph & interactionsWild Yam, Powder
Ginseng Whole Plant Extract
Interacts with217 drugs
American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...
Ginseng Whole Plant Extract monograph & interactionsPuncture Vine Extract
Interacts with259 drugs
Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...
Puncture Vine Extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Carda Lean by Brutal Force Drug Interactions
HelloPharmacist Interaction Report
Carda Lean by Brutal Force contains six ingredients, and we found documented interactions with a total of 723 individual medications across them.
The most serious is Ginseng, which carries a Major interaction with warfarin (a blood thinner): ginseng can reduce warfarin's effectiveness and lower your clotting protection, raising the risk of clots.
Read the full breakdown — every affected drug type, severity by severity
L-Citrulline and L-Arginine Alpha-Ketoglutarate both interact Moderately with blood pressure medications (antihypertensives), ACE inhibitors, and ARBs — they may add to these drugs' blood pressure-lowering effects and increase the risk of dangerously low blood pressure. L-Arginine also interacts with blood thinners (anticoagulants and antiplatelet drugs), potassium-sparing water pills, diabetes medications, and sildenafil (Viagra).
Acetyl-L-Carnitine Hydrochloride has Moderate interactions with antidepressants and related serotonergic drugs (risk of serotonin syndrome), blood thinners including warfarin and acenocoumarol, and thyroid hormone replacement. Puncture Vine Extract (tribulus) interacts Moderately with blood pressure medications, diabetes drugs, and lithium.
We could not check Wild Yam Powder — no interaction data is on file for it. Run your exact medications through the search tool on this page before starting Carda Lean.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Carda Lean?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Carda Lean interact with 723 drugs. Click any drug to see the details.
5 of the 6 ingredients in Carda Lean interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Alpha-Ketoglutarate Puncture Vine Extract Ginseng Whole Plant Extract Acetyl-L-Carnitine Hydrochloride L-Citrulline
Conjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Conjugated Estrogens, Methyltestosterone interactionDiethylstilbestrol, MethyltestosteroneTylosterone
How Diethylstilbestrol, Methyltestosterone interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Diethylstilbestrol, Methyltestosterone interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Esterified Estrogens, Methyltestosterone interactionMethyltestosteroneAndroid 10, Android 25, Metandren, Methitest, Oreton, Testred +1 more
How Methyltestosterone interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Methyltestosterone interactionMethyltestosterone BuccalAndroid 5, Oreton Buccal
How Methyltestosterone Buccal interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Methyltestosterone Buccal interactionTestosteroneAndrogel, Andropatch, Delatestryl, Intrinsa, Natesto, Nebido +3 more
How Testosterone interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Testosterone interactionTestosterone EnanthateXyosted
How Testosterone Enanthate interacts with Carda Lean — through 1 ingredient. Tap an ingredient for the detail:
L-arginine Alpha-ketoglutarateTestosterone Minor
Interaction Summary
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
Read the full L-arginine Alpha-ketoglutarate + Testosterone Enanthate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Carda Lean with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Arginine Alpha-Ketoglutarate
Ace Inhibitors (Aceis)
Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.
Angiotensin Receptor Blockers (Arbs)
Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.
Antihypertensive Drugs
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.
Isoproterenol (Isuprel)
Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.
Potassium-Sparing Diuretics
Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Testosterone
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.
Puncture Vine Extract
Antidiabetes Drugs
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.
Antihypertensive Drugs
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.
Lithium
Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Ginseng Whole Plant Extract
Warfarin (Coumadin)
American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).
Antidiabetes Drugs
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.
Immunosuppressants
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.
Acetyl-L-Carnitine Hydrochloride
Acenocoumarol (Sintrom)
Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.
Serotonergic Drugs
Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.
Thyroid Hormone
Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.
Warfarin (Coumadin)
Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for Carda Lean, from the product label.
Brutal Force
See all Brutal Force products- Name
- Muscle Club Limited
- City
- New York
- State
- NY
- ZipCode
- 10005
- Phone Number
- (646) 893-5892
- Web Address
- brutalforce.com
Carda Lean by Brutal Force: Common Questions
Does Carda Lean by Brutal Force interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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What side effects might I experience?
Is Carda Lean safe during pregnancy or breastfeeding?
Does Carda Lean really improve athletic performance?
What does L-Arginine do?
I'm on lithium for bipolar disorder — can I take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Carda Lean is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Carda Lean’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographL-arginine
Interacts with 403 drugsL-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...
Read the full L-arginine monograph → Herb & supplement monographAcetyl-l-carnitine
Interacts with 203 drugsAcetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...
Read the full Acetyl-l-carnitine monograph → Herb & supplement monographAmerican Ginseng
Interacts with 217 drugsAmerican ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...
Read the full American Ginseng monograph → Herb & supplement monographTribulus
Interacts with 259 drugsTribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...
Read the full Tribulus monograph →Sources & How We Checked
Carda Lean's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 118 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
L-arginine 66 references
- Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
- Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
- Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
- Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
- Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
- Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
- Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
- Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
- Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
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