Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Cartilage+ Ingredients & Drug Interactions

by DaVinci Laboratories Of Vermont

Cartilage+ label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cartilage+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cartilage+ is a dietary supplement by DaVinci Laboratories Of Vermont with 2 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cartilage+ by DaVinci Laboratories Of Vermont

Ask about any prescription or over-the-counter medication and we check it for interactions with Cartilage+ by DaVinci Laboratories Of Vermont — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cartilage+ by DaVinci Laboratories Of Vermont

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Cartilage+ has 2 active ingredients: papain (an enzyme from papaya) and bovine tracheal cartilage (cartilage from cattle). The product also contains gelatin and vegetable stearate as inactive binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cartilage and joint structure support.
  • We looked for evidence on: Wound healing, Joint cartilage, Connective tissue, Chondroitin.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing (Natural Medicines).

The evidence we hold doesn't establish that papain works for cancer, dental caries, radiation dermatitis, exercise-induced muscle soreness, shingles, or intestinal parasites—the data rates all of these as having insufficient reliable evidence. We have no effectiveness information on file for bovine tracheal cartilage.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as food, but supplements may irritate your digestive tract or trigger allergic reactions in sensitive people. Short-term use at normal doses appears safe, though high oral doses may not be.

The safety data advises against concentrated papain and unripe papaya products during pregnancy. For breastfeeding, there isn't enough reliable information; talk with your doctor or pharmacist before using it.

Allergic reactions can include itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. Rarely, high doses have caused serious problems like esophageal perforation (a hole in the food pipe) or severe stomach inflammation.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us if you take warfarin (Coumadin) or any other blood thinner before using this product—papain may increase its effects and your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product isn't well established for the uses listed in the facts. If you take warfarin or any blood thinner, check with us first—papain may make it work harder and raise your bleeding risk.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or have a history of digestive issues or papaya allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cartilage+, straight from the product label.

Brand DaVinci Laboratories Of Vermont
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22002
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cartilage+ by DaVinci Laboratories Of Vermont, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
IngredientAmount% DV
Papain30 mg--
Bovine Tracheal Cartilage1000 mg--

Other ingredients: Gelatin, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

TRUTH We pledge total truth in labeling. Our family of products contain only the purest and most potent ingredients. Guaranteed.

Bovine Tracheal Cartilage is a natural source (165 mg per capsule) of Chondroitin -4- and -6- Sulfates.

Color of this product may vary due to color variations of the natural ingredients.

A Source of Chondroitin -4- and -6- Sulfates

6502700 1011

Formulation

This product is free of citrus, corn, egg, gluten, milk, rice, sodium, soy, wheat, yeast, added sugars, starches, synthetic dyes, artificial flavorings and preservatives.

Precautions

Warning: If you are pregnant nor nursing, consult your health care practitioner before taking this product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

0200441.180 1108A

FDA Statement of Identity

A Dietary Supplement to Support Connective Tissue and Joint Functions

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 capsules with each meal, or as directed by your health care practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cartilage+ by DaVinci Laboratories Of Vermont label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cartilage+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cartilage+ by DaVinci Laboratories Of Vermont

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
30 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bovine Tracheal Cartilage

1000 mg per serving

Other (inactive) ingredients: Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cartilage+ by DaVinci Laboratories Of Vermont Drug Interactions

Want to check YOUR meds against Cartilage+?

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 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Cartilage+ interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Cartilage+ interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Cartilage+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cartilage+, from the product label.

DaVinci Laboratories Of Vermont

See all DaVinci Laboratories Of Vermont products
Name
DaVinci Laboratories of Vermont a division of FoodScience Corp.
Street Address
20 New England Drive
City
Essex Junction
State
VT
ZipCode
05453
Web Address
www.davincilabs.com
Pharmacist Counseling Corner

Cartilage+ by DaVinci Laboratories Of Vermont: Common Questions

Does Cartilage+ by DaVinci Laboratories Of Vermont interact with any medications?
Yes. Based on its ingredients, Cartilage+ has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cartilage+ contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does papain really work for any of these uses?
The facts we hold don't show reliable evidence that papain works for cancer, dental caries, radiation dermatitis, muscle soreness, shingles, or parasites. That doesn't mean it won't help—it just means we don't have strong research backing any of those claims yet.
Can I take this if I'm pregnant?
The safety data advises against concentrated papain and unripe papaya products during pregnancy. Talk with your doctor or pharmacist to weigh the risks and benefits for your situation.
What side effects should I watch for?
Allergic reactions are the most common: itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. It may also irritate your digestive tract. High doses can rarely cause serious stomach or esophageal damage.
Is papain safe if I'm breastfeeding?
There isn't enough reliable safety information about supplemental papain while breastfeeding. Talk with your pharmacist or doctor before using it.
What is papain and where does it come from?
Papain is an enzyme from papaya fruit. It's been used in traditional medicine and is sometimes added to digestive supplements, though its effectiveness for most uses isn't well established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cartilage+ is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cartilage+ label
Go deeper

The Full Monographs Behind Cartilage+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Cartilage+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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