Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Genessentials IM Ingredients & Drug Interactions

by DaVinci Laboratories Of Vermont

Genessentials IM label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Genessentials IM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Genessentials IM is a dietary supplement by DaVinci Laboratories Of Vermont with 4 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 381 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta 1,3 Glucan, Maitake PD-Fraction(TM) Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Genessentials IM by DaVinci Laboratories Of Vermont

Ask about any prescription or over-the-counter medication and we check it for interactions with Genessentials IM by DaVinci Laboratories Of Vermont — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Genessentials IM by DaVinci Laboratories Of Vermont

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Maitake PD-Fraction(TM) Powder” is listed as a grouped ingredient — the label gives one combined amount (17 mg) without saying how much of each component you get.

Genessentials IM has four active ingredients. Beta-glucans — soluble fibers derived from yeast, fungi, and plants — are the only one we could fully evaluate for interactions.

The product also contains dimethylglycine HCl, Maitake mushroom powder (a blend containing D-Fraction), and larch tree arabinogalactan powder, which is another type of soluble fiber. The rest of the tablet is made up of inactive ingredients like cellulose, stearic acid, silicon dioxide, and film-coating agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Beta-glucans's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support proper immune system function.
  • We looked for evidence on: Allergic rhinitis (hay fever), Atopic dermatitis (eczema), Cancer, Chemotherapy-induced anemia, Chemotherapy-induced diarrhea, Chemotherapy-induced leukopenia — and 4 related terms.
  • The closest evidence on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Cancer, Chronic fatigue syndrome (CFS), Atopic dermatitis (eczema).

Beta-glucans in this product are likely effective for dyslipidemia (high blood cholesterol) and coronary heart disease. We hold no effectiveness data for the other three active ingredients — dimethylglycine HCl, Maitake, and larch arabinogalactan.

The evidence, ingredient by ingredient Maitake Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food are generally well tolerated. However, concentrated supplements like this one lack safety data, so use caution.

Oral beta-glucans are well tolerated in most people, though one young patient in a high-dose trial developed temporary elevation of liver enzymes. Topically, beta-glucans can occasionally cause contact dermatitis or mild skin reactions.

We hold no pregnancy or breastfeeding safety information for this product. There's little research on supplement doses during breastfeeding, so talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Maitake Mushroom Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Genessentials IM, check with your doctor or pharmacist if you take blood pressure-lowering drugs or immunosuppressants. Beta-glucans may increase the effect of blood pressure medication, raising the risk of low blood pressure, and may interfere with how immunosuppressants work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with cholesterol and heart health if beta-glucans work for you. If you take blood pressure medication or an immunosuppressant, check with your doctor or pharmacist first — beta-glucans could affect how those drugs work.

The other ingredients haven't been evaluated for drug interactions, so a full review with your healthcare provider is a good idea before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Genessentials IM, straight from the product label.

Brand DaVinci Laboratories Of Vermont
Barcode (UPC) 026664241863
Net contents 60 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22706
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Genessentials IM by DaVinci Laboratories Of Vermont, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
026664241863
IngredientAmount% DV
Dimethylglycine HCl300 mg--
Maitake PD-Fraction(TM) Powder17 mg--
D-Fraction(R)5 mg--
Larch tree (Larix occidentalis) Arabinogalactan Powder227 mg--
Beta 1,3 Glucan100 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetable Stearate, Croscarmellose Sodium, Silicon Dioxide, Hydroxypropyl Methylcellulose, Titanium Dioxide, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

The synergistic and powerful blend of well researched nutrients in GENEssentials(TM) IM was designed specifically to support proper Immune System Function.

Maitake D-Fraction(R) is a registered trademark of Maitake Products, Inc.

General Statements

Color of this product may vary due to color variations of the natural ingredients.

TRUTH We pledge total truth in labeling. Our family of products contain only the purest and most potent ingredients. Guaranteed.

8677700 0911

Precautions

Caution: Discontinue use 2 weeks prior to surgery.

Warning: If pregnant or nursing or have an auto immune disorder or are taking immune suppressant or blood thinning medications, do not take this product without first consulting your health care practitioner.

Keep out of reach of children.

Formula

GENEssentials(TM) IM is an advanced nutritional supplement that combines 3 researched products: Gluconic(R) DMG, Maitake D-Fraction(R) (Maitake mushroom extract,) and ImmuneEnhancer(TM) AG( Larch tree extract) with Beta 1,3 glucans.

Formulation

This product is vegetarian and free of citrus, corn, gluten and rice.

This product is vegetarian and free of citrus, corn, gluten and rice.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

02GS418.060 1209A

FDA Statement of Identity

A Dietary Supplement to Support Immune System Function

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take as directed below: For "ADDED SUPPORT": Take 1 tablet daily. For "EXTRA ADDED SUPPORT": Take 1 tablet, twice daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Genessentials IM by DaVinci Laboratories Of Vermont label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Genessentials IM label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Genessentials IM by DaVinci Laboratories Of Vermont

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dimethylglycine HCl

300 mg per serving

Maitake PD-Fraction(TM) Powder

Interacts with
260 drugs
17 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake PD-Fraction(TM) Powder monograph & interactions
  • › D-Fraction(R)

Larch tree (Larix occidentalis) Arabinogalactan Powder

227 mg per serving

Beta 1,3 Glucan

Interacts with
293 drugs
100 mg per serving Form: baker's yeast

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta 1,3 Glucan monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetable Stearate, Croscarmellose Sodium, Silicon Dioxide, Hydroxypropyl Methylcellulose, Titanium Dioxide, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Genessentials IM by DaVinci Laboratories Of Vermont Drug Interactions

Want to check YOUR meds against Genessentials IM?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
381Drugs
381 Moderate

Ingredients driving the most interactions

Beta 1,3 Glucan 293
Maitake PD-Fraction(TM) Powder 260

Individual Drug Interactions

The ingredients in Genessentials IM interact with 381 drugs. Click any drug to see the details.

2 of the 4 ingredients in Genessentials IM interact with drugs. Each result below shows which ingredient is responsible. Beta 1,3 Glucan Maitake PD-Fraction(TM) Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Genessentials IM with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta 1,3 Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta 1,3 Glucan full monograph & interactions

Maitake PD-Fraction(TM) Powder3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake PD-Fraction(TM) Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Genessentials IM, from the product label.

DaVinci Laboratories Of Vermont

See all DaVinci Laboratories Of Vermont products
Name
DaVinci Laboratories of Vermont a division of FoodScience Corp.
Street Address
20 New England Drive, Suite 10
City
Essex Junction
State
VT
ZipCode
05452
Web Address
www.davincilabs.com
Pharmacist Counseling Corner

Genessentials IM by DaVinci Laboratories Of Vermont: Common Questions

Does Genessentials IM by DaVinci Laboratories Of Vermont interact with any medications?
Yes. Based on its ingredients, Genessentials IM has a known interaction with 381 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Genessentials IM contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for high cholesterol?
Beta-glucans, the ingredient we have data for, are likely effective for high cholesterol (dyslipidemia) and heart disease. We don't have effectiveness information on the other ingredients.
Can I take this if I'm pregnant or breastfeeding?
We don't have safety data for this product during pregnancy or breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing — they can give you advice based on your situation.
What side effects might I experience?
Beta-glucans are well tolerated when taken by mouth. One trial patient on a very high dose developed temporary liver enzyme elevation. If you apply beta-glucan products to skin, contact dermatitis or mild skin reactions can occur in some people.
What is beta-glucan, and why is it in here?
Beta-glucans are soluble fibers found in yeast, mushrooms, and plants. They're included because research shows they may help lower cholesterol and support heart health.
What are Maitake and larch arabinogalactan?
Maitake is a mushroom that has been used in traditional medicine. Larch arabinogalactan is a soluble fiber from the larch tree. We don't have effectiveness data for either one in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Genessentials IM is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Genessentials IM label
Go deeper

The Full Monographs Behind Genessentials IM’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Genessentials IM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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