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Dietary supplement

Cat's Claw 800 mg Ingredients & Drug Interactions

by Peruvian Naturals

Cat's Claw 800 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cat's Claw 800 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cat's Claw 800 mg is a dietary supplement by Peruvian Naturals with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 962 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cat's Claw, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cat's Claw 800 mg by Peruvian Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Cat's Claw 800 mg by Peruvian Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cat's Claw 800 mg by Peruvian Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: cat's claw powder at 800 mg per tablet. Cat's claw is a tropical vine traditionally used in herbal medicine.

The inactive ingredients are microcrystalline cellulose, calcium carbonate, stearic acid, magnesium stearate, silicon dioxide, and hypromellose — standard tablet binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cat's Claw product and its label doesn't state a use — see Cat's Claw's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for cat's claw isn't established in our data. The product facts list six conditions — allergic rhinitis (hay fever), Alzheimer disease, asthma, osteoporosis, cancer, and chronic fatigue syndrome — but all are rated as having insufficient reliable evidence to rate its effectiveness.

If you're considering it for one of these, talk to your pharmacist or doctor about what the current science actually supports.

The evidence, ingredient by ingredient Cat's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cat's claw is generally well tolerated in short-term use in healthy adults, but how it performs long-term isn't well studied. The safety data advises against it during pregnancy because of its traditional use as an abortifacient and lack of safety data.

Avoid it while breastfeeding too — there isn't enough information to know it's safe. Case reports have linked cat's claw to kidney injury in a small number of people, including one with lupus and another who took it in keto shakes.

In one clinical trial (though patients had advanced cancer with no other treatment options), a small number experienced anemia, leukopenia (low white blood cells), thrombocytopenia (low platelets), headache, fatigue, insomnia, and neuropathy (nerve damage). Because those patients had serious disease, it's unclear whether cat's claw caused these or the cancer did.

Side effects, ingredient by ingredient Cat's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cat's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 963 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check your exact medications against these drug types: blood thinners and antiplatelet drugs (moderate risk of bleeding), blood pressure medications and calcium channel blockers (moderate risk of low blood pressure), drugs metabolized by CYP3A4 (moderate risk of changed levels), immune-suppressing medications (moderate risk of reduced effect), and nirmatrelvir/ritonavir/Paxlovid (moderate risk of reduced antiviral effect). Use the checker on this page to search your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cat's Claw may be worth considering if you're interested in traditional herbal support, but the evidence for what it actually does isn't established. If you take any blood thinners, blood pressure medications, immune-suppressing drugs, or medications broken down by your liver, you need to check with your pharmacist first.

Avoid it in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cat's Claw 800 mg, straight from the product label.

Brand Peruvian Naturals
Barcode (UPC) 793611595446
Net contents 150 Tablet(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283417
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cat's Claw 800 mg by Peruvian Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
150
UPC/BARCODE
793611595446
IngredientAmount% DV
Cat's Claw, Powder800 mg--

Other ingredients: Microcrystalline Cellulose, Calcium Carbonate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cat's Claw Uncaria tormentosa Cat's Claw is a woody vine found in the tropical rainforests of South America. The name derives from the small, curved spines on the stem which resemble the claws of a cat. The bark has been brewed into tea by the indigenous Ashaninka tribe for centuries.

General Statements

Three percent of Peruvian Naturals earnings are donated to small farms and agricultural businesses in rural Peru.

For more information, visit www.peruviannaturals.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Cat's Claw is not a substitute for a varied diet. Do not exceed 5 tablets per day.

Warning: Not recommended for pregnant or nursing women.

Keep out of reach of children.

Brand IP Statement(s)

Native Herbs Peruvian Naturals

FDA Statement of Identity

Herbal Supplement

Formulation

Wild Grown

100% Vegan

Suggested/Recommended/Usage/Directions

Directions: Take two to three tablets per day with meals.

Storage

Store at room temperature between 60 degrees and 90 degrees Fahrenheit (15 degrees and 30 degrees Celsius).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cat's Claw 800 mg by Peruvian Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cat's Claw 800 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cat's Claw 800 mg by Peruvian Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container150 Amounts shown are per serving.

Cat's Claw, Powder

Interacts with
962 drugs
800 mg per serving

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arth...

Cat's Claw, Powder monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Calcium Carbonate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cat's Claw 800 mg by Peruvian Naturals Drug Interactions

Want to check YOUR meds against Cat's Claw 800 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
962Drugs
962 Moderate

Ingredients driving the most interactions

Cat's Claw, Powder 962

Individual Drug Interactions

The ingredients in Cat's Claw 800 mg interact with 962 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cat's Claw 800 mg interact with drugs. Each result below shows which ingredient is responsible. Cat's Claw, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Cat's Claw 800 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cat's Claw, Powder6 drug types · 962 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cat's Claw, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cat's Claw 800 mg, from the product label.

Peruvian Naturals

See all Peruvian Naturals products
Name
Peruvian Naturals
Street Address
4423 Vance Ave
City
St. Louis
State
MO
ZipCode
63134
Web Address
www.peruviannaturals.com
Pharmacist Counseling Corner

Cat's Claw 800 mg by Peruvian Naturals: Common Questions

Does Cat's Claw 800 mg by Peruvian Naturals interact with any medications?
Yes. Based on its ingredients, Cat's Claw 800 mg has a known interaction with 962 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cat's Claw 800 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is cat's claw safe to take if I'm pregnant or breastfeeding?
The safety data advises against it during pregnancy because of its traditional use as an abortifacient and lack of safety studies. Avoid it while breastfeeding too — there isn't enough information yet. Talk with your doctor or pharmacist if you're pregnant or planning to be.
What are the side effects I might experience?
Short-term, cat's claw is generally well tolerated in healthy people. One clinical trial in cancer patients reported anemia, low white blood cells, low platelets, headache, fatigue, insomnia, and nerve damage, but those patients had advanced cancer, so it's unclear if cat's claw caused them. Case reports have also linked it to kidney injury in rare instances.
Does cat's claw actually work for any of the conditions listed?
The evidence isn't established in our data. All the conditions mentioned — hay fever, Alzheimer disease, asthma, osteoporosis, cancer, and chronic fatigue — are rated as having insufficient reliable evidence. Talk to your pharmacist about what science currently supports for your specific interest.
How long can I safely take this supplement?
Cat's claw is generally well tolerated in the short term in healthy adults, but how safe it is to take long-term isn't well studied. If you're thinking of using it regularly, check with your pharmacist.
Will cat's claw interfere with my blood pressure medication?
Possibly. Cat's claw may lower blood pressure further on its own, and it may also have effects similar to calcium channel blockers. If you take any blood pressure medication, check it with your pharmacist or doctor before starting cat's claw — the combination could cause dizziness or fainting.
Does this product contain any fillers?
Yes. The inactive ingredients are microcrystalline cellulose, calcium carbonate, stearic acid, magnesium stearate, silicon dioxide, and hypromellose — binders and fillers that help form the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cat's Claw 800 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cat's Claw 800 mg label
Go deeper

The Full Monographs Behind Cat's Claw 800 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cat's Claw

Interacts with 962 drugs

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...

Read the full Cat's Claw monograph →
Sources

Sources & How We Checked

Cat's Claw 800 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cat's Claw 16 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  4. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
  5. Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
  6. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
  7. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
  8. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  9. Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
  10. Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
  11. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
  12. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
  13. Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
  14. De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
  15. Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
  16. Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed

See these in context on the Cat's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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