Chewable DigestEnz Ingredients & Drug Interactions
by ProEnzol
What is this page for?
First and foremost: checking Chewable DigestEnz against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chewable DigestEnz is a dietary supplement by ProEnzol with 18 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Chewable DigestEnz by ProEnzol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Chewable DigestEnz is a blend of 17 digestive enzymes designed to help break down food in your digestive tract. The main active ingredients are protease (which breaks down protein), lipase (which breaks down fat), lactase (which breaks down lactose in dairy), and several others including cellulase, amylase, and phytase.
The product also contains inactive ingredients like plant fiber, natural flavoring, citric acid, and magnesium stearate to hold the tablet together and improve taste.
Does it work?
Strong evidence
The evidence we hold is limited. Lactase is established as effective for lactose intolerance — if you have trouble digesting dairy, this ingredient has solid support.
For the other enzymes in this product, the data shows insufficient evidence to rate their effectiveness for digestive conditions like dyspepsia (indigestion), inflammatory bowel disease, or other uses. That doesn't mean they don't work; it means the research isn't there yet to say.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated when used as directed. A small number of people have reported digestive upset or allergic reactions; protease in particular has rarely triggered allergic responses in workers exposed to powdered enzyme.
Phytase carries similar caution — it's considered low-risk in foods, but human supplement data are limited. Lactase is rated as likely safe in pregnancy, though you should check with your doctor before regular use.
For protease and phytase in pregnancy, the data either advises against use or isn't established enough — talk with your doctor or pharmacist. During breastfeeding, protease has little safety data and isn't recommended without medical advice; lipase and phytase also have limited breastfeeding data, so ask your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we were unable to check nine of the product's ingredients, so ask your pharmacist to review your specific medications before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product is a blend of digestive enzymes intended to support food breakdown. If you have lactose intolerance, lactase has evidence behind it.
For the other enzymes, the research support is thin. Because we couldn't check all 17 ingredients for drug interactions, mention this product to your pharmacist before you start, especially if you take any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chewable DigestEnz, straight from the product label.
| Brand | ProEnzol |
|---|---|
| Barcode (UPC) | 707636129838 |
| Net contents | 180 Vegan Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 244153 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chewable DigestEnz by ProEnzol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sugar | 0 Gram(s) | -- |
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Erythritol | 1 Gram(s) | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| SF Chewable DigestEnz Blend | 96 mg | -- |
| Protease | 24 mg | -- |
| Protease | 23 mg | -- |
Other ingredients: Plant Fiber, Natural flavor, natural Beet, Natural Spirulina, Stearic Acid, Magnesium Stearate, Citric Acid, Silica, Proprietary plant-derived flavoring
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
ProEnzol (Sugar Free) Chewable DigestEnz provides a broad-spectrum of non-animal derived digestive enzymes, including gluten-digesting ProteaseGL and casein/whey-digesting ProteaseCW to assist the body's own enzymes break down dietary protein, carbohydrates, fat and fiber, making food nutrients more readily available for optimal absorption.
Ideal for children ages 4 and up.
With gluten, casein, & whey-digesting enzymes
Natural mixed berry flavor Natural raspberry lemonade flavor
Suggested/Recommended/Usage/Directions
Directions: Chew one (1) tablet at the beginning of each meal, or as directed by your healthcare professional. Ideal for children ages 4 and up.
Precautions
Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.
Use only if tamper-evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
Brand IP Statement(s)
ProteaseGL and ProteaseCW are trademarks of Enzymes Inc.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure, or prevent any disease.
Formulation
Sugar free
Contains no: sugar, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).
FDA Statement of Identity
Dietary Supplement
General Statements
Exclusively for professionals
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chewable DigestEnz by ProEnzol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chewable DigestEnz by ProEnzol
These are the 18 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegan Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Erythritol
SF Chewable DigestEnz Blend
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsProtease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsOther (inactive) ingredients: Plant Fiber, Natural flavor, Natural Beet, Natural Spirulina, Stearic Acid, Magnesium Stearate, Citric Acid, Silica, Proprietary plant-derived flavoring. These complete the product’s ingredient list but are not active constituents.
Chewable DigestEnz by ProEnzol Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Chewable DigestEnz. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Chewable DigestEnz, from the product label.
ProEnzol
See all ProEnzol products- Name
- Enzymes Inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 1-800-637-7893
- Web Address
- www.proenzol.com
Chewable DigestEnz by ProEnzol: Common Questions
Does Chewable DigestEnz by ProEnzol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this help with lactose intolerance?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What's erythritol in the ingredients?
Can protease cause allergies?
Is this safe for someone with serious digestive conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chewable DigestEnz is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chewable DigestEnz’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Chewable DigestEnz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC