Chewable DigestEnz Natural Pomegranate Acai Ingredients & Drug Interactions
by ProEnzol
What is this page for?
First and foremost: checking Chewable DigestEnz Natural Pomegranate Acai against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chewable DigestEnz Natural Pomegranate Acai is a dietary supplement by ProEnzol with 18 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Chewable DigestEnz Natural Pomegranate Acai by ProEnzol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 18 active ingredients — a blend of digestive enzymes designed to help break down different components of food. Protease breaks down proteins, Lipase breaks down fats, and Lactase breaks down lactose (milk sugar).
You'll also find Cellulase, Peptidase, Invertase, Glucoamylase, Alpha-Galactosidase, Xylanase, Pectinase, Maltase, Beta-Glucanase, Phytase, Hemicellulase, Diastase, and others — each targeting different carbohydrates and fiber. The inactive ingredients include natural flavors from pomegranate and acai, sweetened with allulose and monk fruit extract, plus standard tablet binders and flow agents.
Does it work?
Strong evidence
For Lactase, the evidence shows it is effective for lactose intolerance — that's the main reason people use lactase supplements. For the other enzymes in this product, the effectiveness evidence we hold is insufficient to rate them for any condition, including inflammatory bowel disease, indigestion, and other digestive issues.
That doesn't mean they don't work; it means the data we have isn't robust enough to say one way or the other. Most digestive enzyme blends are sold on the premise they'll ease general digestion, but proving that in a clinical trial is tricky.
How safe is it?
Well-documented data
Protease, Lipase, Lactase, and Phytase are generally well tolerated. Protease and Lactase can occasionally trigger allergic reactions — rare, but it happens.
The main concern is pregnancy and breastfeeding: Protease is best avoided during pregnancy unless your doctor prescribes it, and there's little safety data during breastfeeding. Lipase and Phytase also have limited pregnancy and breastfeeding data; check with your doctor before regular use if you're pregnant or nursing.
Lactase is likely safe in pregnancy. For the other 11 enzymes, we have no safety data on file.
One rare adverse effect to know: occupational exposure to powdered digestive enzymes (especially in factories) has triggered allergic reactions like asthma and rhinitis, but taking them as a chewable tablet poses a much lower risk.
Meds to double-check
No known interactions
No interactions are documented for the ingredients we could check. However, we could not verify interaction data for over half the enzymes in this blend.
If you take any prescription medications, check them with the search tool on this page before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you have lactose intolerance, this product's Lactase content can help. For general digestive support, the evidence for the other enzymes isn't established in our data.
The product is generally well tolerated, but if you're pregnant or breastfeeding, talk with your doctor or pharmacist first — safety data are limited for several of the active ingredients. Anyone with a history of enzyme allergies should be cautious.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chewable DigestEnz Natural Pomegranate Acai, straight from the product label.
| Brand | ProEnzol |
|---|---|
| Barcode (UPC) | 707636120439 |
| Net contents | 180 Vegan Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 322815 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chewable DigestEnz Natural Pomegranate Acai by ProEnzol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Total Sugars | 1 Gram(s) | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| ProteaseGL | 20 mg | -- |
| DigestEnz Chewable Blend | 288 mg | -- |
| ProteaseCW | 30 mg | -- |
Other ingredients: Allulose, Tapioca Dextrin, Pomegranate, Acai, Malic Acid, Beet Juice, Natural, Monk Fruit Extract, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
ProEnzol DigestEnz Chewables provides and excellent, broad-spectrum blend of acid-resistant, non-animal derived digestive enzymes, including gluten-digesting ProteaseGL and casein/whey-digesting ProteaseCW, to assist the body's own enzymes break down and assimilate dietary protein, carbohydrates, fat and fiber, for relief of occasional digestive discomfort.
Sweetened with all-natural allulose
Suggested/Recommended/Usage/Directions
Directions: chew one to two (1-2) tablets at the beginning of each meal, or as directed by your healthcare professional.
Precautions
Caution: if you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.
Use only if tamper-evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
Brand IP Statement(s)
ProteaseGL & ProteaseCW are trademarks of Enzymes Inc.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General Statements
Exclusively for professionals
Formulation
Contains no: sucrose, fructose, dextrose, sugar alcohols, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chewable DigestEnz Natural Pomegranate Acai by ProEnzol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chewable DigestEnz Natural Pomegranate Acai by ProEnzol
These are the 18 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegan Chewable Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
ProteaseGL
DigestEnz Chewable Blend
ProteaseCW
Other (inactive) ingredients: Allulose, Tapioca Dextrin, Pomegranate, Acai, Malic Acid, Beet Juice, Natural, Monk Fruit Extract, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Chewable DigestEnz Natural Pomegranate Acai by ProEnzol Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Chewable DigestEnz Natural Pomegranate Acai. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Chewable DigestEnz Natural Pomegranate Acai, from the product label.
ProEnzol
See all ProEnzol products- Name
- Enzymes Inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 1-800-637-7893
- Web Address
- www.proenzol.com
Chewable DigestEnz Natural Pomegranate Acai by ProEnzol: Common Questions
Does Chewable DigestEnz Natural Pomegranate Acai by ProEnzol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help me digest food better if I don't have lactose intolerance?
Can I take this if I'm pregnant?
What does Phytase do?
Are there any side effects from this product?
Is it safe to breastfeed while taking this?
What's the difference between all these enzymes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chewable DigestEnz Natural Pomegranate Acai is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chewable DigestEnz Natural Pomegranate Acai’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Chewable DigestEnz Natural Pomegranate Acai's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC