CholestOff Plus Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking CholestOff Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CholestOff Plus is a dietary supplement by Nature Made with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, heart health support, lowering ldl cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of CholestOff Plus by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CholestOff Plus contains two active ingredients: plant sterols and plant stanols. These are plant-derived compounds structurally similar to cholesterol; they work by blocking cholesterol absorption in your intestines, which helps lower blood cholesterol levels.
The product also contains several inactive ingredients — sunflower oil esters, gelatin, glycerin, medium chain triglyceride, rapeseed lecithin, water, and added colors — that serve as the capsule shell and carrier.
Does it work?
Strong evidence
Plant sterols are likely effective for lowering cholesterol in people with high cholesterol levels and in familial hypercholesterolemia, a genetic condition that raises cholesterol from birth. For heart disease prevention and management, the evidence shows they're possibly effective.
We hold no effectiveness data for plant stanols in our facts.
How safe is it?
Some data gaps
Plant sterols are generally well tolerated at typical doses in most adults. During pregnancy, safety data on concentrated supplements is limited, so caution is advised — talk with your doctor before using if you're pregnant or breastfeeding.
In clinical trials, abdominal discomfort has been reported in one child. Rarely, cases of skin rash and, in one young child who took very high daily amounts of a plant sterol product, signs related to reproductive hormone effects have been described, though these reversed when the product was stopped.
Meds to double-check
No known interactions
No interactions are documented in our data for the plant sterols we checked. We hold no interaction data for plant stanols.
Use the medication checker on this page to verify your specific drugs, and ask your doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
CholestOff Plus is a reasonable option if you're looking to support cholesterol management with plant sterols and stanols — the evidence supports their use for high cholesterol. If you're pregnant, breastfeeding, or take any medications, discuss it with your doctor or pharmacist first to make sure it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CholestOff Plus, straight from the product label.
| Brand | Nature Made |
|---|---|
| Net contents | 100 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 270710 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Approved Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CholestOff Plus by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Fat | 1.5 Gram(s) | 2% |
| Protein | 1 Gram(s) | -- |
| Plant Sterols and Plant Stanols | 900 mg | -- |
| Plant Sterols | 0 NP | -- |
| Plant Stanols | 0 NP | -- |
Other ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglyceride, Rapeseed Lecithin, Water, Colors added
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Daily sterol & stanol amounts Diet CholestOff Daily recommended amount Amount of Phytosterols The National Institutes of Health (NIH) Therapeutic Lifestyle Change guidelines recommends: 2000 mg Many Americans consume as little as: - 200 mg CholestOff Plus provides additional: 1800 mg
Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as a part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.
100% money back guarantee For details visit NatureMade.com/guarantee #1 pharmacist recommended vitamin & supplement brand
Based on a survey of pharmacists who recommend branded vitamins and supplements.
Formula
One serving of Nature Made CholestOff Plus supplies 900 mg of plant sterols and stanols for a daily intake of 1800 mg.
With 900 mg plant sterols & stanols per serving
Nature Made CholestOff Plus is made with esterified Reducol, a proprietary blend of plant-based sterols and stanols (also called phytosterols) which help lower LDL ("bad") cholesterol. Reducol lowers cholesterol by reducing the absorption of dietary cholesterol into the bloodstream. CholestOff Plus is an easy-to-swallow softgel.
Seals/Symbols
USP Dietary Supplement Verified
Formulation
Clinically proven to lower cholesterol
No synthetic dyes - colors derived from natural sources No artificial flavors No preservatives Gluten free
USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org
Before taking CholestOff Plus dietary cholesterol is absorbed into the bloodstream After taking CholestOff Plus less dietary cholesterol is absorbed into the bloodstream
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Adults, take 2 softgels twice daily with water at your two largest meals.
Storage
Store tightly closed, in a cool, dry place, out of reach of children.
Precautions
Store tightly closed, in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Caution: If you are pregnant, nursing, or taking any medications, consult your physician before use.
Sterols/Stanols are esterified with sunflower oil fatty acids.
Brand IP Statement(s)
Reducol is a trademark of Pharmachem Laboratories Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CholestOff Plus by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CholestOff Plus by Nature Made
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Plant Sterols and Plant Stanols
No knowninteractions
Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...
Plant Sterols and Plant Stanols monograph & interactions- › Plant Sterols
- › Plant Stanols
Other (inactive) ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglyceride, Rapeseed Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.
CholestOff Plus by Nature Made Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in CholestOff Plus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for CholestOff Plus, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- West Hills
- State
- CA
- ZipCode
- 91309-9903
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
CholestOff Plus by Nature Made: Common Questions
Does CholestOff Plus by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this lower my cholesterol?
Is it safe to take if I'm pregnant or breastfeeding?
What are plant sterols and plant stanols?
What side effects have been reported?
Do I need to worry about interactions with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CholestOff Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CholestOff Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CholestOff Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Plant Sterols 3 references
- Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
- Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
- Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC