Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Choline 800 mg Ingredients & Drug Interactions

by Nature Made

Choline 800 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline 800 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline 800 mg is a dietary supplement by Nature Made with 2 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline 800 mg by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline 800 mg by Nature Made — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline 800 mg by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline, a nutrient your body uses for cell function and brain health. Each capsule delivers 800 mg.

The inactive ingredients are hypromellose, magnesium stearate, cellulose gel, and silicon dioxide — these are binders and capsule materials that help deliver the active ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Choline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support memory, mood and muscle health.
  • We looked for evidence on: Cognitive function, Age-related cognitive decline, Dementia, Alzheimer disease, Depression, Infant development — and 4 related terms.
  • The closest evidence on file: Choline is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, and more.

The evidence for choline on most conditions is limited. For athletic performance, the data suggests it's likely ineffective.

For bronchitis, age-related memory loss, liver problems from total parenteral nutrition, hay fever, and Alzheimer's disease, we don't have enough reliable evidence to say whether it works or not.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline at the dose in this product (800 mg) is well tolerated by most people. However, doses above the daily upper limit of 3.5 grams can cause side effects — fishy body odor is the most common, and at very high doses (9 grams or more daily), people have reported nausea, vomiting, diarrhea, and sweating.

The safety data shows that choline is important during pregnancy and breastfeeding, but you should use it only at the dose your doctor recommends rather than choosing your own supplement amount.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine, double-check with your pharmacist before starting choline — it may reduce atropine's effects in the brain (Minor severity). No other interactions are documented for choline in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Choline 800 mg is generally well tolerated at this dose and may be worth considering if you're interested in nutrient supplementation. If you take atropine (used for certain eye or heart conditions), check with your pharmacist before starting.

Talk to your pharmacist about whether this dose and form are right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline 800 mg, straight from the product label.

Brand Nature Made
Barcode (UPC) 031604004330
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 335195
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline 800 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
20
UPC/BARCODE
031604004330
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Choline800 mg145%
Protein1 Gram(s)--

Other ingredients: Hypromellose, Magnesium Stearate, Cellulose Gel, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 Pharmacist recommended vitamin & supplement brand Based on a survey of pharmacists who recommended branded vitamins and supplements

90% of adults do not meet the recommended intake levels for choline.

Formula

Choline Extra strength dosage 800 mg per 3 capsules

Formulation

Clinically studied ingredient Supports focused attention Helps support memory, mood and muscle health Choline helps make acetylcholine to support memory, mood, and muscle health In young adults

No color added No artificial flavors No preservatives Gluten free

Vegetarian

Encapsulated and quality tested in the USA. Made to our guaranteed purity and potency standards.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults, take 3 capsules daily with water and a meal.

Storage

Store tightly closed, in a cool, dry place, out of reach of children.

Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if seal under cap is broken or missing.

Caution: If you are pregnant, nursing, taking medications or have any chronic medical conditions, consult your physician before use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline 800 mg by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline 800 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline 800 mg by Nature Made

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Choline

Interacts with
16 drugs
800 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Protein

1 Gram(s) per serving

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Cellulose Gel, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline 800 mg by Nature Made Drug Interactions

Want to check YOUR meds against Choline 800 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline 800 mg interact with 16 drugs. Click any drug to see the details.

1 of the 2 ingredients in Choline 800 mg interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline 800 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline 800 mg, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
West Hills
State
CA
ZipCode
91309-9903
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

Choline 800 mg by Nature Made: Common Questions

Does Choline 800 mg by Nature Made interact with any medications?
Yes. Based on its ingredients, Choline 800 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline 800 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will choline help my memory or prevent Alzheimer's?
The evidence isn't established yet. We don't have enough reliable data to say whether choline helps with age-related memory loss or Alzheimer's disease. Talk with your doctor about whether this supplement makes sense for you.
What are the side effects at this dose?
At 800 mg daily, choline is generally well tolerated. Side effects mainly happen at doses above 3.5 grams per day — the most common is a fishy body odor. At very high doses (9 grams or more daily), some people report nausea, vomiting, diarrhea, and sweating.
Is it safe to take while pregnant or breastfeeding?
The safety data rates choline as likely safe in pregnancy and breastfeeding. However, your choline needs are higher during these times, so use only the dose your doctor or midwife advises rather than picking a supplement amount on your own.
Can I take this if I use atropine?
Choline may theoretically reduce how well atropine works in your brain. If you take atropine (for eye drops, heart conditions, or other uses), check with your pharmacist before starting this supplement.
Does this product have fillers?
Yes. The capsule contains hypromellose, magnesium stearate, cellulose gel, and silicon dioxide — these are inactive ingredients that help deliver the choline.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline 800 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline 800 mg label
Go deeper

The Full Monographs Behind Choline 800 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline 800 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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