Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

CinSulin with InSea2 and Crominex 3+ Ingredients & Drug Interactions

by Life Extension

CinSulin with InSea2 and Crominex 3+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CinSulin with InSea2 and Crominex 3+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CinSulin with InSea2 and Crominex 3+ is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 527 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are CinSulin Cinnamon Water extract, Chromium, Iodine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CinSulin with InSea2 and Crominex 3+ by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with CinSulin with InSea2 and Crominex 3+ by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CinSulin with InSea2 and Crominex 3+ by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 4 active ingredients.
  • “CinSulin Cinnamon Water extract” is listed as a grouped ingredient — the label gives one combined amount (175 mg) without saying how much of each component you get.
  • “InSea2” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

This product has 4 active ingredients: chromium (in the Crominex 3+ blend), iodine, a cinnamon extract (CinSulin), and a polyphenol-rich compound (InSea2). The inactive ingredients are standard capsule materials and fillers — vegetable cellulose, microcrystalline cellulose, silica, and vegetable stearate.

Chromium is a mineral that plays a role in how your body handles blood sugar. Iodine is essential for your thyroid.

The cinnamon extract and InSea2 are plant-based compounds added for their polyphenol content, though we held no interaction data on those specific blends to check.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: blood sugar and glucose metabolism support.
  • We looked for evidence on: Chromium deficiency, Diabetes, Dyslipidemia, Hyperlipidemia, Impaired glucose tolerance (prediabetes), Iodine deficiency — and 4 related terms.
  • The strongest evidence on file: Iodine is rated "Likely Effective" for Iodine deficiency (Natural Medicines).
  • Also on file: Chromium is rated "Likely Effective" for Chromium deficiency.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

Chromium is likely effective for correcting chromium deficiency and possibly effective for type 2 diabetes — some research suggests it may help lower blood sugar in people whose diabetes isn't well controlled. For prediabetes, the evidence points toward it being possibly ineffective.

Iodine is likely effective for preventing thyroid problems when iodine intake is inadequate and for protecting the thyroid after radiation exposure. Evidence for iodine in gum disease and mouth sores is rated possibly effective.

The cinnamon and InSea2 ingredients do not have effectiveness ratings on file in our data.

The evidence, ingredient by ingredient Chromium Iodine Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses. The most common side effects are gastrointestinal upset, headaches, insomnia, irritability, and mood changes.

Rare serious effects — kidney or liver damage, a muscle breakdown condition called rhabdomyolysis, and low platelet counts — have been reported with higher or long-term doses. Skin reactions including rashes and hives are also possible.

Iodine is well tolerated in normal dietary amounts, but high doses can trigger thyroid problems in either direction (overactive or underactive). Common effects include nausea, diarrhea, metallic taste, headache, and goiter.

Rare but serious hypersensitivity reactions including anaphylaxis have been reported. During pregnancy, adequate iodine is important but only in the amount your doctor advises — avoid high-dose products.

Smaller amounts in breast milk are generally acceptable with medical guidance.

Side effects, ingredient by ingredient Chromium Iodine Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Iodine, Chromium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 185 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before starting: diabetes medications and insulin (risk of low blood sugar), levothyroxine or other thyroid hormones (chromium may reduce absorption), lithium (iodine may worsen thyroid effects), antithyroid drugs (iodine may interfere), amiodarone (risk of excess iodine), NSAIDs and aspirin (may increase chromium levels). These are Moderate severity concerns except NSAIDs and aspirin, which are Minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

CinSulin with InSea2 and Crominex 3+ is worth considering if you want chromium and iodine support for blood sugar or thyroid health — but only after checking it against your exact medications. If you take diabetes drugs, insulin, a thyroid hormone, lithium, an antithyroid medicine, or amiodarone, you need to talk with your pharmacist or doctor first.

High doses or long-term use need monitoring.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CinSulin with InSea2 and Crominex 3+, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870150398
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231917
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CinSulin with InSea2 and Crominex 3+ by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
UPC/BARCODE
737870150398
IngredientAmount% DV
Chromium133 mcg380%
Iodine20 mcg13%
CinSulin Cinnamon Water extract175 mg--
Type-A Polymers4.375 mg--
InSea2100 mg--
demineralized Polyphenols0 NP--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule 20-30 minutes before each meal not exceeding three (3) capsules daily, or as recommended by a healthcare practitioner. Best results are achieved by taking this product along with maintaining a proper diet and regular exercise.

Precautions

Caution: If you are taking blood glucose lowering medication, consult your healthcare provider before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Non GMO LE Certified

Formulation

Non GMO LE Certified

Helps maintain healthy glucose for those already within normal range

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Crominex 3+, Capros and PrimaVie are registered trademarks of Natreon, Inc., CinSulin is a registered trademark of Tang-An Medical Ltd., manufactured under U.S. patent No. 6,200,569. InSea2 is a registered trademark of InnoVactiv.

Formula

Crominex 3+ Chrominex safety & efficacy

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CinSulin with InSea2 and Crominex 3+ by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CinSulin with InSea2 and Crominex 3+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CinSulin with InSea2 and Crominex 3+ by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
133 mcg per serving Form: Crominex 3+ Chromium

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Iodine

Interacts with
7 drugs
20 mcg per serving Form: Bladderwrack, Kelp

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodine monograph & interactions

CinSulin Cinnamon Water extract

Interacts with
444 drugs
175 mg per serving

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

CinSulin Cinnamon Water extract monograph & interactions
  • › Type-A Polymers

InSea2

100 mg per serving
  • › Demineralized Polyphenols

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

CinSulin with InSea2 and Crominex 3+ by Life Extension Drug Interactions

Want to check YOUR meds against CinSulin with InSea2 and Crominex 3+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
527Drugs
449 Moderate 78 Minor

Ingredients driving the most interactions

CinSulin Cinnamon Water extract 444
Chromium 178
Iodine 7

Individual Drug Interactions

The ingredients in CinSulin with InSea2 and Crominex 3+ interact with 527 drugs. Click any drug to see the details.

3 of the 4 ingredients in CinSulin with InSea2 and Crominex 3+ interact with drugs. Each result below shows which ingredient is responsible. CinSulin Cinnamon Water extract Chromium Iodine

Each ingredient & the kinds of drugs it affects

For each ingredient in CinSulin with InSea2 and Crominex 3+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

CinSulin Cinnamon Water extract2 drug types · 444 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
CinSulin Cinnamon Water extract full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Iodine3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Iodine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CinSulin with InSea2 and Crominex 3+, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

CinSulin with InSea2 and Crominex 3+ by Life Extension: Common Questions

Does CinSulin with InSea2 and Crominex 3+ by Life Extension interact with any medications?
Yes. Based on its ingredients, CinSulin with InSea2 and Crominex 3+ has a known interaction with 527 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CinSulin with InSea2 and Crominex 3+ contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my blood sugar?
Chromium is possibly effective for type 2 diabetes — some research shows it may lower blood sugar in people whose diabetes isn't well controlled. If you take insulin or diabetes medication, though, chromium might add to their effect and lower your blood sugar too much, so you'll need to discuss this with your doctor or pharmacist first.
Is it safe to take if I'm pregnant or nursing?
Chromium is rated likely safe in pregnancy. For iodine, adequate amounts are important in pregnancy — but only take what your doctor advises, and avoid high-dose products. Some iodine passes into breast milk, so follow your doctor's guidance there too.
What are the most common side effects?
Chromium commonly causes gastrointestinal upset, headaches, insomnia, irritability, and mood changes. Iodine commonly causes nausea, diarrhea, metallic taste, and headache. Most people tolerate it well at typical doses, but high or long-term doses carry more risk.
Can I take this with my levothyroxine?
Chromium may bind levothyroxine in your gut and reduce how much you absorb by around 17%. If you take levothyroxine, space this product at least 2 hours apart and talk to your pharmacist about the best timing for your specific dose.
What is InSea2 and does it interact with medications?
InSea2 is a blend of plant-derived polyphenols. We hold no interaction data for this blend or its components, so we couldn't check for drug interactions. Run it through the search tool on this page with your exact medications to be sure.
Is this product tested for all ingredients?
We have interaction data for chromium and iodine. We could not check Type-A Polymers and demineralized Polyphenols — there's no monograph on file for those. That doesn't mean they interact; it means we don't have the data to assess them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CinSulin with InSea2 and Crominex 3+ is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CinSulin with InSea2 and Crominex 3+ label
Go deeper

The Full Monographs Behind CinSulin with InSea2 and Crominex 3+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 444 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph →
Sources

Sources & How We Checked

CinSulin with InSea2 and Crominex 3+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 101 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
  21. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
  22. John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
  23. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
  24. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  25. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
  26. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
  27. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
  28. Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
  29. Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
  30. Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
  31. Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
  32. Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
  33. Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
  34. Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
  35. Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
  36. Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
  37. Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
  38. Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
  39. Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
  40. Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
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Iodine 28 references
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Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
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See these in context on the Cassia Cinnamon monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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